In vitro bioassay determination of dioxin-like and estrogenic activity in sediment and water from Ulsan bay and its vicinity, Korea
Extracts of sediment and water samples collected from Ulsan Bay, Korea, were screened for their ability to induce dioxin-like and estrogenic gene expression in vitro. Each sample was tested as raw extract (RE) and fractionated extract (FE). Based on the initial screening of RE, 23 of 31 sediment sam...
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| Veröffentlicht in: | Archives of environmental contamination and toxicology 2001-02, Vol.40 (2), p.151-160 |
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| description | Extracts of sediment and water samples collected from Ulsan Bay, Korea, were screened for their ability to induce dioxin-like and estrogenic gene expression in vitro. Each sample was tested as raw extract (RE) and fractionated extract (FE). Based on the initial screening of RE, 23 of 31 sediment samples showed significant dioxin-like activity in H4IIE-luc bioassay, whereas most sediment samples did not elicit estrogenic response in MVLN bioassay. Most of the activities associated with FE samples revealed that mid-polar (F2) and most polar (F3) fractions were responsible for the significant reporter gene expression in H4IIE-luc bioassay. The results suggest that complex interactions may have depressed the activities of the known arylhydrocarbon receptor (AhR) agonists present in F1 samples. The F2 samples were the most active fraction. All F2 samples except one induced significant dioxin-like activity, and over half of the F2 samples induced significant estrogenic activity. Ten of the F2 samples produced magnitudes of response in H4IIE-luc bioassay similar to those induced by a 2,3,7,8-tetrachlorodibenzo-p-dioxin standard. Sediment associated with F2 samples was estimated to contain 24.9-826 pg TCDD-EQ/g DW. Based on a qualitative mass balance analysis, polycyclic aromatic hydrocarbons (PAHs) appeared to account for both the estrogenic and dioxin-like responses observed. Over half of the F3 samples were either cytotoxic or caused morphological changes in both H4IIE-luc and MVLN cells. Known concentrations of alkylphenols and bisphenol A were not great enough to account for both the estrogenic response and cytotoxicity observed for F3 samples. Despite the apparent toxic or stressful effects, most of F3 samples induced significant dioxin-like activity in vitro, adding to a growing body of evidence that suggests the presence of unidentified, relatively polar, AhR agonists in sediment from some areas. |
| doi_str_mv | 10.1007/s002440010158 |
| format | Article |
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S ; LEE, K. T ; VILLENEUVE, D. L ; KANNAN, K ; GIESY, J. P ; KOH, C. H</creator><creatorcontrib>KHIM, J. S ; LEE, K. T ; VILLENEUVE, D. L ; KANNAN, K ; GIESY, J. P ; KOH, C. H</creatorcontrib><description>Extracts of sediment and water samples collected from Ulsan Bay, Korea, were screened for their ability to induce dioxin-like and estrogenic gene expression in vitro. Each sample was tested as raw extract (RE) and fractionated extract (FE). Based on the initial screening of RE, 23 of 31 sediment samples showed significant dioxin-like activity in H4IIE-luc bioassay, whereas most sediment samples did not elicit estrogenic response in MVLN bioassay. Most of the activities associated with FE samples revealed that mid-polar (F2) and most polar (F3) fractions were responsible for the significant reporter gene expression in H4IIE-luc bioassay. The results suggest that complex interactions may have depressed the activities of the known arylhydrocarbon receptor (AhR) agonists present in F1 samples. The F2 samples were the most active fraction. All F2 samples except one induced significant dioxin-like activity, and over half of the F2 samples induced significant estrogenic activity. Ten of the F2 samples produced magnitudes of response in H4IIE-luc bioassay similar to those induced by a 2,3,7,8-tetrachlorodibenzo-p-dioxin standard. Sediment associated with F2 samples was estimated to contain 24.9-826 pg TCDD-EQ/g DW. Based on a qualitative mass balance analysis, polycyclic aromatic hydrocarbons (PAHs) appeared to account for both the estrogenic and dioxin-like responses observed. Over half of the F3 samples were either cytotoxic or caused morphological changes in both H4IIE-luc and MVLN cells. Known concentrations of alkylphenols and bisphenol A were not great enough to account for both the estrogenic response and cytotoxicity observed for F3 samples. Despite the apparent toxic or stressful effects, most of F3 samples induced significant dioxin-like activity in vitro, adding to a growing body of evidence that suggests the presence of unidentified, relatively polar, AhR agonists in sediment from some areas.</description><identifier>ISSN: 0090-4341</identifier><identifier>EISSN: 1432-0703</identifier><identifier>DOI: 10.1007/s002440010158</identifier><identifier>PMID: 11243316</identifier><identifier>CODEN: AECTCV</identifier><language>eng</language><publisher>Heidelberg: Springer-Verlag</publisher><subject>Animals ; Applied sciences ; Bioassays ; Biological Assay ; Bisphenol A ; Cytotoxicity ; Dioxins ; Dioxins - analysis ; Estrogens, Non-Steroidal - analysis ; Exact sciences and technology ; Fish ; Gas Chromatography-Mass Spectrometry ; Gene Expression ; Humans ; Korea ; Korea, Rep., Ulsan Bay ; Korea, Ulsan Bay ; Luciferases - genetics ; Pollution ; Polycyclic aromatic hydrocarbons ; Rats ; Sediment samplers ; Sediments ; Soil Pollutants - analysis ; TCDD ; Tumor Cells, Cultured ; Water analysis ; Water Pollutants, Chemical - analysis ; Water sampling ; Water treatment and pollution ; xenoestrogens</subject><ispartof>Archives of environmental contamination and toxicology, 2001-02, Vol.40 (2), p.151-160</ispartof><rights>2001 INIST-CNRS</rights><rights>Springer-Verlag New York Inc. 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a461t-36a9a449de42dd8d14ac34a50e71d05ba6883eb115651a2f364ae46f12b2fcd83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27931,27932</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=949690$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11243316$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KHIM, J. S</creatorcontrib><creatorcontrib>LEE, K. T</creatorcontrib><creatorcontrib>VILLENEUVE, D. L</creatorcontrib><creatorcontrib>KANNAN, K</creatorcontrib><creatorcontrib>GIESY, J. P</creatorcontrib><creatorcontrib>KOH, C. H</creatorcontrib><title>In vitro bioassay determination of dioxin-like and estrogenic activity in sediment and water from Ulsan bay and its vicinity, Korea</title><title>Archives of environmental contamination and toxicology</title><addtitle>Arch Environ Contam Toxicol</addtitle><description>Extracts of sediment and water samples collected from Ulsan Bay, Korea, were screened for their ability to induce dioxin-like and estrogenic gene expression in vitro. Each sample was tested as raw extract (RE) and fractionated extract (FE). Based on the initial screening of RE, 23 of 31 sediment samples showed significant dioxin-like activity in H4IIE-luc bioassay, whereas most sediment samples did not elicit estrogenic response in MVLN bioassay. Most of the activities associated with FE samples revealed that mid-polar (F2) and most polar (F3) fractions were responsible for the significant reporter gene expression in H4IIE-luc bioassay. The results suggest that complex interactions may have depressed the activities of the known arylhydrocarbon receptor (AhR) agonists present in F1 samples. The F2 samples were the most active fraction. All F2 samples except one induced significant dioxin-like activity, and over half of the F2 samples induced significant estrogenic activity. Ten of the F2 samples produced magnitudes of response in H4IIE-luc bioassay similar to those induced by a 2,3,7,8-tetrachlorodibenzo-p-dioxin standard. Sediment associated with F2 samples was estimated to contain 24.9-826 pg TCDD-EQ/g DW. Based on a qualitative mass balance analysis, polycyclic aromatic hydrocarbons (PAHs) appeared to account for both the estrogenic and dioxin-like responses observed. Over half of the F3 samples were either cytotoxic or caused morphological changes in both H4IIE-luc and MVLN cells. Known concentrations of alkylphenols and bisphenol A were not great enough to account for both the estrogenic response and cytotoxicity observed for F3 samples. Despite the apparent toxic or stressful effects, most of F3 samples induced significant dioxin-like activity in vitro, adding to a growing body of evidence that suggests the presence of unidentified, relatively polar, AhR agonists in sediment from some areas.</description><subject>Animals</subject><subject>Applied sciences</subject><subject>Bioassays</subject><subject>Biological Assay</subject><subject>Bisphenol A</subject><subject>Cytotoxicity</subject><subject>Dioxins</subject><subject>Dioxins - analysis</subject><subject>Estrogens, Non-Steroidal - analysis</subject><subject>Exact sciences and technology</subject><subject>Fish</subject><subject>Gas Chromatography-Mass Spectrometry</subject><subject>Gene Expression</subject><subject>Humans</subject><subject>Korea</subject><subject>Korea, Rep., Ulsan Bay</subject><subject>Korea, Ulsan Bay</subject><subject>Luciferases - genetics</subject><subject>Pollution</subject><subject>Polycyclic aromatic hydrocarbons</subject><subject>Rats</subject><subject>Sediment samplers</subject><subject>Sediments</subject><subject>Soil Pollutants - analysis</subject><subject>TCDD</subject><subject>Tumor Cells, Cultured</subject><subject>Water analysis</subject><subject>Water Pollutants, Chemical - analysis</subject><subject>Water sampling</subject><subject>Water treatment and pollution</subject><subject>xenoestrogens</subject><issn>0090-4341</issn><issn>1432-0703</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkT1vFDEQhi0EIkegpEWWkKhYmLG9Xm-JIj4iIqUh9WrW9iKHXTvYe8DV_HF8yQlImlQu5pln_Opl7DnCGwTo3hYAoRQAArbmAdugkqKBDuRDtgHooVFS4RF7UsplhYQx6jE7QhRKStQb9vs08h9hzYmPIVEptOPOrz4vIdIaUuRp4i6kXyE2c_jmOUXHfan8Vx-D5WTXUNd3PERevAuLj-s185OqhE85LfxiLhT5WM37QVhLPWhDrFuv-eeUPT1ljyaai392eI_ZxYf3X04-NWfnH09P3p01pDSujdTUk1K980o4ZxwqslJRC75DB-1I2hjpR8RWt0hiklqRV3pCMYrJOiOP2asb71VO37c1xbCEYv08U_RpWwbsDAgUcD-o0bRa6vtBVf_SdnvjyzvgZdrmWNMO2GJXU3VaVKq5oWxOpWQ_DVc5LJR3A8Kwb3u41XblXxys23Hx7h99qPe_s1QszVOmaEP5y_Wq1z3IP2SXsQo</recordid><startdate>20010201</startdate><enddate>20010201</enddate><creator>KHIM, J. 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S</au><au>LEE, K. T</au><au>VILLENEUVE, D. L</au><au>KANNAN, K</au><au>GIESY, J. P</au><au>KOH, C. H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro bioassay determination of dioxin-like and estrogenic activity in sediment and water from Ulsan bay and its vicinity, Korea</atitle><jtitle>Archives of environmental contamination and toxicology</jtitle><addtitle>Arch Environ Contam Toxicol</addtitle><date>2001-02-01</date><risdate>2001</risdate><volume>40</volume><issue>2</issue><spage>151</spage><epage>160</epage><pages>151-160</pages><issn>0090-4341</issn><eissn>1432-0703</eissn><coden>AECTCV</coden><abstract>Extracts of sediment and water samples collected from Ulsan Bay, Korea, were screened for their ability to induce dioxin-like and estrogenic gene expression in vitro. Each sample was tested as raw extract (RE) and fractionated extract (FE). Based on the initial screening of RE, 23 of 31 sediment samples showed significant dioxin-like activity in H4IIE-luc bioassay, whereas most sediment samples did not elicit estrogenic response in MVLN bioassay. Most of the activities associated with FE samples revealed that mid-polar (F2) and most polar (F3) fractions were responsible for the significant reporter gene expression in H4IIE-luc bioassay. The results suggest that complex interactions may have depressed the activities of the known arylhydrocarbon receptor (AhR) agonists present in F1 samples. The F2 samples were the most active fraction. All F2 samples except one induced significant dioxin-like activity, and over half of the F2 samples induced significant estrogenic activity. Ten of the F2 samples produced magnitudes of response in H4IIE-luc bioassay similar to those induced by a 2,3,7,8-tetrachlorodibenzo-p-dioxin standard. Sediment associated with F2 samples was estimated to contain 24.9-826 pg TCDD-EQ/g DW. Based on a qualitative mass balance analysis, polycyclic aromatic hydrocarbons (PAHs) appeared to account for both the estrogenic and dioxin-like responses observed. Over half of the F3 samples were either cytotoxic or caused morphological changes in both H4IIE-luc and MVLN cells. Known concentrations of alkylphenols and bisphenol A were not great enough to account for both the estrogenic response and cytotoxicity observed for F3 samples. Despite the apparent toxic or stressful effects, most of F3 samples induced significant dioxin-like activity in vitro, adding to a growing body of evidence that suggests the presence of unidentified, relatively polar, AhR agonists in sediment from some areas.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><cop>New York, NY</cop><pub>Springer-Verlag</pub><pmid>11243316</pmid><doi>10.1007/s002440010158</doi><tpages>10</tpages></addata></record> |
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| ispartof | Archives of environmental contamination and toxicology, 2001-02, Vol.40 (2), p.151-160 |
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| language | eng |
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| subjects | Animals Applied sciences Bioassays Biological Assay Bisphenol A Cytotoxicity Dioxins Dioxins - analysis Estrogens, Non-Steroidal - analysis Exact sciences and technology Fish Gas Chromatography-Mass Spectrometry Gene Expression Humans Korea Korea, Rep., Ulsan Bay Korea, Ulsan Bay Luciferases - genetics Pollution Polycyclic aromatic hydrocarbons Rats Sediment samplers Sediments Soil Pollutants - analysis TCDD Tumor Cells, Cultured Water analysis Water Pollutants, Chemical - analysis Water sampling Water treatment and pollution xenoestrogens |
| title | In vitro bioassay determination of dioxin-like and estrogenic activity in sediment and water from Ulsan bay and its vicinity, Korea |
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