The Apical Caspase dronc Governs Programmed and Unprogrammed Cell Death in Drosophila

Among the seven caspases encoded in the fly genome, only dronc contains a caspase recruitment domain. To assess the function of this gene in development, we produced a null mutation in dronc. Animals lacking zygotic dronc are defective for programmed cell death (PCD) and arrest as early pupae. These...

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Veröffentlicht in:	Developmental cell 2004-12, Vol.7 (6), p.897-907
Hauptverfasser:	Chew, Su Kit, Akdemir, Fatih, Chen, Po, Lu, Wan-Jin, Mills, Kathryn, Daish, Tasman, Kumar, Sharad, Rodriguez, Antony, Abrams, John M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Apoptosis Body Patterning Caspases - metabolism Caspases - physiology Cell Death Drosophila Drosophila melanogaster Drosophila Proteins - physiology Eye - embryology Eye - metabolism Gene Expression Regulation, Developmental Genetic Complementation Test Genome Genotype Green Fluorescent Proteins - metabolism Hemocytes - metabolism Homozygote Image Processing, Computer-Assisted Immunohistochemistry In Situ Nick-End Labeling Models, Genetic Mutagenesis Mutation Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Time Factors
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