Cyclosporine-A mimicked the ischemic pre- and postconditioning-mediated cardioprotection in hypertensive rats: Role of PKCε

Our aim was to assess the action of cyclosporine-A (CsA) against reperfusion injury in spontaneously hypertensive rats (SHR) compared to the effects of ischemic pre- (IP) and postconditioning (IPC), examining the role played by PKCε. Isolated hearts were submitted to the following protocols: IC: 45m...

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Veröffentlicht in:	Experimental and molecular pathology 2016-04, Vol.100 (2), p.266-275
Hauptverfasser:	González Arbeláez, Luisa Fernanda, Ciocci Pardo, Alejandro, Fantinelli, Juliana Catalina, Mosca, Susana María
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzophenanthridines - pharmacology Calcium - metabolism Cardiotonic Agents - pharmacology CsA Cyclosporine - pharmacology Cytochromes c - metabolism Enzyme Inhibitors - pharmacology Glutathione - metabolism Glycogen Synthase Kinase 3 Glycogen Synthase Kinase 3 beta Heart - drug effects Heart - physiopathology Hypertension - metabolism Hypertension - physiopathology Immunoblotting In Vitro Techniques Ischemic postconditioning Ischemic preconditioning Ischemic Preconditioning, Myocardial - methods Mitochondria, Heart - drug effects Mitochondria, Heart - metabolism mPTP Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - physiopathology Myocardial Reperfusion Injury - prevention & control Myocardium - metabolism PKCε Protein Kinase C-epsilon - antagonists & inhibitors Protein Kinase C-epsilon - metabolism Proto-Oncogene Proteins c-akt - metabolism Rats, Inbred SHR Thiobarbituric Acid Reactive Substances - metabolism Time Factors
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