Activated human B cells induce inflammatory fibroblasts with cartilage-destructive properties and become functionally suppressed in return

BackgroundCross-talk between synovial fibroblasts (SF) and immune cells is suggested to play a crucial role in inflammation and chronification of rheumatoid arthritis (RA). The contribution of B cells in this process is poorly defined.MethodsHere, primary B cells from healthy donors were polyclonall...

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Veröffentlicht in:	Annals of the rheumatic diseases 2016-05, Vol.75 (5), p.924-932
Hauptverfasser:	Störch, Hannah, Zimmermann, Birgit, Resch, Bastian, Tykocinski, Lars-Oliver, Moradi, Babak, Horn, Patrick, Kaya, Ziya, Blank, Norbert, Rehart, Stefan, Thomsen, Marc, Lorenz, Hanns-Martin, Neumann, Elena, Tretter, Theresa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Arthritis Arthritis, Rheumatoid - immunology B-Lymphocytes - immunology Cartilage Cartilage, Articular - immunology Cell culture Coculture Techniques Cytokines Cytokines - biosynthesis Experiments Fibroblasts Fibroblasts - immunology Flow cytometry Heterografts Humans Immune Tolerance - immunology Inflammation Mediators - metabolism Interleukin-1beta - immunology Lymphocyte Activation - immunology Matrix Metalloproteinases - biosynthesis Mice, SCID Osteoarthritis Osteoarthritis - immunology Signal Transduction - immunology Synovial Fluid - immunology Transforming Growth Factor beta - immunology Tumor Necrosis Factor-alpha - immunology Tumor necrosis factor-TNF
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