Thymic Activity and T Cell Repertoire Recovery after Autologous Hematopoietic Stem Cell Transplantation Preceded by Myeloablative Radiotherapy or Chemotherapy

Abstract It was previously postulated that pretransplant myeloablative treatment may impair thymopoiesis, contributing in this way to delayed reconstitution of T cells after hematopoietic stem cell transplantation (HSCT). On the other hand, de novo generation of T cells after HSCT requires a compete...

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Veröffentlicht in:	Biology of blood and marrow transplantation 2016-05, Vol.22 (5), p.834-842
Hauptverfasser:	Głowala-Kosińska, Magdalena, Chwieduk, Agata, Smagur, Andrzej, Fidyk, Wojciech, Najda, Jacek, Mitrus, Iwona, Giebel, Sebastian
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic Combined Chemotherapy Protocols - administration & dosage Autografts Carmustine - administration & dosage Cyclophosphamide - administration & dosage Cytarabine - administration & dosage Female Hematology, Oncology and Palliative Medicine Hematopoietic Stem Cell Transplantation Hodgkin Disease - metabolism Hodgkin Disease - therapy Humans Male Melphalan - administration & dosage Middle Aged Podophyllotoxin - administration & dosage Recent thymic emigrants (RTEs) Stem cell transplantation (autoHSCT) Thymic output Thymus Gland - metabolism Thymus Gland - pathology Transplantation Conditioning - methods T cell receptor (TCR) repertoire T cell reconstitution Whole-Body Irradiation
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