Over-expression of survivin is a factor responsible for differential responses of ovarian cancer cells to S-allylmercaptocysteine (SAMC)

While investigating the inhibitory effect of S-allylmercaptocysteine (SAMC), a garlic derivative, on ovarian cancer, we subjected three ovarian cancer cell lines, HO8910, HO8910PM, and SKOV3, to SAMC treatment. In vivo and in vitro experiments showed that only HO8910 and SKOV3 cells were highly sens...

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Veröffentlicht in:	Experimental and molecular pathology 2016-04, Vol.100 (2), p.294-302
Hauptverfasser:	Wu, Jun, Zhao, Song, Zhang, Jian, Qu, Xuemei, Jiang, Shuwan, Zhong, Zhaohua, Zhang, Fengmin, Wong, Yongchuan, Chen, He
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Phytogenic - pharmacology Apoptosis - drug effects Apoptosis - genetics Blotting, Western Cadherins - metabolism Caspase 3 - genetics Caspase 3 - metabolism Cell Line, Tumor Cell Movement - drug effects Cell Movement - genetics Cell Proliferation - drug effects Cell Proliferation - genetics Cysteine - analogs & derivatives Cysteine - pharmacology Drug resistance E-cadherin Female Garlic - chemistry Gene Expression Regulation, Neoplastic Humans Inhibitor of Apoptosis Proteins - genetics Integrin beta1 - metabolism Integrin β1 Mice, Inbred BALB C Mice, Nude Ovarian cancer Ovarian Neoplasms - drug therapy Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA Interference S-allylmercaptocysteine Surviving Tumor Stem Cell Assay Xenograft Model Antitumor Assays
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