TRIM28 as an independent prognostic marker plays critical roles in glioma progression

Tripartite motif (TRIM) proteins are involved in tumorigenesis. Here, we examined the expression, biological function, and clinical significance of tripartite motif containing 28 (TRIM28) in glioma, a locally aggressive brain tumor. First, TRIM28 expression was significantly higher in glioma (n = 13...

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Veröffentlicht in:	Journal of neuro-oncology 2016-01, Vol.126 (1), p.19-26
Hauptverfasser:	Qi, Zeng-Xin, Cai, Jia-Jun, Chen, Ling-Chao, Yue, Qi, Gong, Yan, Yao, Yu, Mao, Ying
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Brain - metabolism Brain - pathology Brain Neoplasms - diagnosis Brain Neoplasms - mortality Cell Cycle Checkpoints - genetics Cell Line, Tumor Cyclin-Dependent Kinase Inhibitor p21 - genetics Cyclin-Dependent Kinase Inhibitor p21 - metabolism Disease Progression Female Gene Expression Regulation - genetics Glioma - diagnosis Glioma - genetics Glioma - mortality Humans Laboratory Investigation Male Medicine Medicine & Public Health Mice Mice, Nude Middle Aged Neurology Oncology Repressor Proteins - genetics Repressor Proteins - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Survival Analysis Time Factors Tripartite Motif-Containing Protein 28 Xenograft Model Antitumor Assays
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