Sustained Local Release of Methylprednisolone From a Thiol-Acrylate Poly(Ethylene Glycol) Hydrogel for Treating Chronic Compressive Radicular Pain

STUDY DESIGN.A preclinical animal model of chronic ligation of the sciatic nerve was used to compare the effectiveness of a slow-release hydrogel carrying methylprednisolone to methylprednisolone injection alone, which simulates the current standard of care for chronic compressive radiculopathy (CR)...

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Veröffentlicht in:	Spine (Philadelphia, Pa. 1976) Pa. 1976), 2016-04, Vol.41 (8), p.E441-E448
Hauptverfasser:	Slotkin, Jonathan R, Ness, Jennifer K, Snyder, Kristin M, Skiles, Amanda A, Woodard, Eric J, OʼShea, Timothy, Layer, Rick T, Aimetti, Alex A, Toms, Steven A, Langer, Robert, Tapinos, Nikos
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chronic Pain - drug therapy Disease Models, Animal Gait - drug effects Hydrogels - administration & dosage Hydrogels - therapeutic use Low Back Pain - drug therapy Male Methylprednisolone - administration & dosage Methylprednisolone - pharmacokinetics Methylprednisolone - pharmacology Methylprednisolone - therapeutic use Pain Measurement Polyethylene Glycols Radiculopathy - physiopathology Rats Rats, Sprague-Dawley Sciatic Nerve - injuries
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