Evaluation of developmental toxicity of 1-butanol given to rats in drinking water throughout pregnancy

The objective of this study was to evaluate the developmental toxicity of 1-butanol in rats. Pregnant rats were given drinking water containing 1-butanol at 0.2%, 1.0% or 5.0% (316, 1454 or 5654mg/kg/day) on days 0–20 of pregnancy. A significant decrease in maternal body weight gain accompanied by r...

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Veröffentlicht in:	Food and chemical toxicology 2005-02, Vol.43 (2), p.325-331
Hauptverfasser:	Ema, M., Hara, H., Matsumoto, M., Hirose, A., Kamata, E.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Butanol 1-Butanol - toxicity abnormal development Abnormalities, Drug-Induced - epidemiology Abnormalities, Drug-Induced - etiology acute effects Administration, Oral Animals beverages Biological and medical sciences Bone Development - drug effects butanol Developmental toxicity Dose-Response Relationship, Drug Drinking drinking water Drug Evaluation, Preclinical environmental exposure Female Fetal abnormality Fetal Development - drug effects Fetal Weight - drug effects fetotoxicity flavorings food composition Male Maternal Exposure Medical sciences No-Observed-Adverse-Effect Level nutrient intake Pregnancy pregnancy outcome Rat Rats reproductive toxicology Teratogenicity Teratogens - toxicity Time Factors Toxicology Weight Gain - drug effects
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