Identification and Characterization of Functionally Important Elements in the Multidrug Resistance Protein 1 COOH-terminal Region

The ATP binding cassette (ABC) transporter, multidrug resistance protein 1 (MRP1/ABCC1), transports a broad spectrum of conjugated and unconjugated compounds, including natural product chemotherapeutic agents. In this study, we have investigated the importance of the COOH-terminal region of MRP1 for...

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Veröffentlicht in:	The Journal of biological chemistry 2004-12, Vol.279 (51), p.53571-53583
Hauptverfasser:	Westlake, Christopher J., Payen, Lea, Gao, Mian, Cole, Susan P.C., Deeley, Roger G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - chemistry Amino Acid Sequence Animals ATP Binding Cassette Transporter, Subfamily B, Member 1 - chemistry Cell Line Cell Membrane - metabolism Codon Crystallography, X-Ray Cytoplasm - metabolism Dogs Dose-Response Relationship, Drug Enhancer Elements, Genetic Hydrolysis Immunoblotting Insecta Kinetics Leukotriene C4 - chemistry Molecular Sequence Data Mutagenesis Mutagenesis, Site-Directed Mutation Point Mutation Protein Binding Protein Structure, Secondary Protein Structure, Tertiary Protein Transport Time Factors Vanadates - chemistry
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