The Type IV phosphodiesterase inhibitor rolipram interferes with drug-induced conditioned place preference but not immediate early gene induction in mice

Behavioural effects of psychostimulant and opiate drugs are mediated in part by cAMP pathways operating in the nucleus accumbens. Degradation of cAMP occurs through the action of phosphodiesterases, such as the Type IV phosphodiesterases (PDE4s) that are found throughout the brain. To examine the po...

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Veröffentlicht in:	The European journal of neuroscience 2004-05, Vol.19 (9), p.2561-2568
Hauptverfasser:	Thompson, Barbara E., Sachs, Benjamin D., Kantak, Kathleen M., Cherry, James A.
Format:	Artikel
Sprache:	eng
Schlagworte:	3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors accumbens addiction Animals Basal Ganglia - anatomy & histology Basal Ganglia - drug effects Basal Ganglia - metabolism c-fos Cell Count - methods Cocaine - pharmacology Conditioning, Operant - drug effects cyclic AMP Cyclic Nucleotide Phosphodiesterases, Type 4 Dopamine Uptake Inhibitors - pharmacology Dose-Response Relationship, Drug Drug Interactions food Gene Expression Regulation - drug effects Male Mice morphine Morphine - pharmacology Phosphodiesterase Inhibitors - pharmacology Proto-Oncogene Proteins c-fos - metabolism reward Rolipram - pharmacology striatum Transcriptional Activation
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