Design of a Highly Reactive HDV Ribozyme Sequence Uncovers Facilitation of RNA Folding by Alternative Pairings and Physiological Ionic Strength

The hepatitis delta virus (HDV) ribozyme is a self-cleaving RNA that resides in the HDV genome and regulates its replication. The native fold of the ribozyme is complex, having two pseudoknots. Earlier work implicated four non-native pairings in slowing pseudoknot formation: Alt 1, Alt 2, Alt 3, and...

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Veröffentlicht in:	Journal of molecular biology 2004-08, Vol.341 (3), p.695-712
Hauptverfasser:	Brown, Trevor S., Chadalavada, Durga M., Bevilacqua, Philip C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalytic Domain folding guide Hepatitis D virus hepatitis delta virus Hepatitis Delta Virus - chemistry Hepatitis Delta Virus - genetics Ions Kinetics Magnesium - chemistry Magnetic Resonance Spectroscopy Models, Chemical Models, Statistical Mutagenesis, Site-Directed Mutation Nucleic Acid Conformation Oligonucleotides - chemistry Oligonucleotides, Antisense - chemistry Phylogeny Protein Folding ribozyme RNA - chemistry RNA folding RNA, Catalytic - chemistry RNA, Catalytic - genetics Sodium - chemistry therapeutic Thermodynamics Time Factors Urea - chemistry
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