Cooperation of the N-terminal Helicase and C-terminal Endonuclease Activities of Archaeal Hef Protein in Processing Stalled Replication Forks

Blockage of replication fork progression often occurs during DNA replication, and repairing and restarting stalled replication forks are essential events in all organisms for the maintenance of genome integrity. The repair system employs processing enzymes to restore the stalled fork. In Archaea Hef...

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Veröffentlicht in:	The Journal of biological chemistry 2004-12, Vol.279 (51), p.53175-53185
Hauptverfasser:	Komori, Kayoko, Hidaka, Masumi, Horiuchi, Takashi, Fujikane, Ryosuke, Shinagawa, Hideo, Ishino, Yoshizumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - chemistry Adenosine Triphosphatases - metabolism Adenosine Triphosphate - chemistry Archaea Archaea - metabolism Archaeal Proteins - chemistry Archaeal Proteins - physiology Base Sequence Blotting, Western Chromatography, Gel DNA - chemistry DNA - metabolism DNA Helicases - metabolism Dose-Response Relationship, Drug Endonucleases - chemistry Escherichia coli - metabolism Genetic Vectors Genome, Bacterial Hydrolysis Models, Genetic Molecular Sequence Data Mutation Plasmids - metabolism Protein Binding Protein Structure, Tertiary Recombinant Proteins - chemistry Recombinant Proteins - metabolism Substrate Specificity Time Factors
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