Translesion Synthesis past 2′-Deoxyxanthosine, a Nitric Oxide-derived DNA Adduct, by Mammalian DNA Polymerases

Cellular DNA is damaged by nitric oxide (NO), a multifunctional bioregulator and an environmental pollutant that has been implicated in diseases associated with cancer and chronic inflammation. 2′-Deoxyxanthosine (dX) is a major NO-derived DNA lesion. To explore the mutagenic potential of dX, a 38-m...

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Veröffentlicht in:	Journal of molecular biology 2004-11, Vol.344 (3), p.665-674
Hauptverfasser:	Yasui, Manabu, Suzuki, Naomi, Miller, Holly, Matsuda, Tomonari, Matsui, Saburo, Shibutani, Shinya
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Chromatography, High Pressure Liquid Deoxyribonucleosides - chemistry deoxyxanthosine DNA adduct DNA Adducts DNA polymerase DNA Repair DNA-Directed DNA Polymerase - metabolism Kinetics nitric oxide Nitric Oxide - chemistry Oligodeoxyribonucleotides Templates, Genetic translesion synthesis
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