Peripartum Cardiomyopathy
Peripartum cardiomyopathy is a potentially life-threatening pregnancy-associated disease that typically arises in the peripartum period and is marked by left ventricular dysfunction and heart failure. The disease is relatively uncommon, but its incidence is rising. Women often recover cardiac functi...
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| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 2016-04, Vol.133 (14), p.1397-1409 |
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| container_title | Circulation (New York, N.Y.) |
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| creator | Arany, Zolt Elkayam, Uri |
| description | Peripartum cardiomyopathy is a potentially life-threatening pregnancy-associated disease that typically arises in the peripartum period and is marked by left ventricular dysfunction and heart failure. The disease is relatively uncommon, but its incidence is rising. Women often recover cardiac function, but long-lasting morbidity and mortality are not infrequent. Management of peripartum cardiomyopathy is largely limited to the same neurohormonal antagonists used in other forms of cardiomyopathy, and no proven disease-specific therapies exist yet. Research in the past decade has suggested that peripartum cardiomyopathy is caused by vascular dysfunction, triggered by late-gestational maternal hormones. Most recently, information has also indicated that many cases of peripartum cardiomyopathy have genetic underpinnings. We review here the known epidemiology, clinical presentation, and management of peripartum cardiomyopathy, as well as the current knowledge of the pathophysiology of the disease. |
| doi_str_mv | 10.1161/CIRCULATIONAHA.115.020491 |
| format | Article |
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The disease is relatively uncommon, but its incidence is rising. Women often recover cardiac function, but long-lasting morbidity and mortality are not infrequent. Management of peripartum cardiomyopathy is largely limited to the same neurohormonal antagonists used in other forms of cardiomyopathy, and no proven disease-specific therapies exist yet. Research in the past decade has suggested that peripartum cardiomyopathy is caused by vascular dysfunction, triggered by late-gestational maternal hormones. Most recently, information has also indicated that many cases of peripartum cardiomyopathy have genetic underpinnings. 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The disease is relatively uncommon, but its incidence is rising. Women often recover cardiac function, but long-lasting morbidity and mortality are not infrequent. Management of peripartum cardiomyopathy is largely limited to the same neurohormonal antagonists used in other forms of cardiomyopathy, and no proven disease-specific therapies exist yet. Research in the past decade has suggested that peripartum cardiomyopathy is caused by vascular dysfunction, triggered by late-gestational maternal hormones. Most recently, information has also indicated that many cases of peripartum cardiomyopathy have genetic underpinnings. We review here the known epidemiology, clinical presentation, and management of peripartum cardiomyopathy, as well as the current knowledge of the pathophysiology of the disease.</description><subject>Bromocriptine - therapeutic use</subject><subject>Cardiomyopathies - diagnosis</subject><subject>Cardiomyopathies - epidemiology</subject><subject>Cardiomyopathies - etiology</subject><subject>Cardiomyopathies - therapy</subject><subject>Cardiovascular Agents - therapeutic use</subject><subject>Disease Susceptibility</subject><subject>Female</subject><subject>Heart Failure - etiology</subject><subject>Heart Transplantation</subject><subject>Hormones - blood</subject><subject>Humans</subject><subject>Hypertension - complications</subject><subject>Incidence</subject><subject>Infant, Newborn</subject><subject>Lactation - drug effects</subject><subject>Pre-Eclampsia - physiopathology</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Cardiovascular - diagnosis</subject><subject>Pregnancy Complications, Cardiovascular - epidemiology</subject><subject>Pregnancy Complications, Cardiovascular - etiology</subject><subject>Pregnancy Complications, Cardiovascular - therapy</subject><subject>Pregnancy, Multiple</subject><subject>Puerperal Disorders - diagnosis</subject><subject>Puerperal Disorders - epidemiology</subject><subject>Puerperal Disorders - etiology</subject><subject>Puerperal Disorders - therapy</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE1Lw0AQhhdRbK3-AC-iNy-ps9_uMQS1hWJF2vOSbHdpNDFxN6H037slVRCGGeblnQ8ehO4wTDEW-CGbv2frRbqaL1_TWRo1PgUCTOETNMacsIRxqk7RGABUIikhI3QRwkdsBZX8HI2IBMYxeRyj6zfryzb3XV_fZrnflE29b9q82-4v0ZnLq2CvjnWC1s9Pq2yWLJYv8yxdJIZJpRITkwNBBHfukRKjOHYuhrTMcWkoEwIcxgQb5gQpiDBGUUWMwa4g0hR0gu6Hva1vvnsbOl2Xwdiqyr9s0weNpVRACBYQrWqwGt-E4K3TrS_r3O81Bn0go_-TiRrXA5k4e3M80xe13fxN_qKIBjYYdk3VWR8-q35nvd7avOq2OrIDClgmBOInDDgkB0nRHzPebms</recordid><startdate>20160405</startdate><enddate>20160405</enddate><creator>Arany, Zolt</creator><creator>Elkayam, Uri</creator><general>by the American College of Cardiology Foundation and the American Heart Association, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160405</creationdate><title>Peripartum Cardiomyopathy</title><author>Arany, Zolt ; Elkayam, Uri</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4799-c799f06265ff832c951ff1ff7e4f57c34660f1121c4f62b26cc9392cc1fb27cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Bromocriptine - therapeutic use</topic><topic>Cardiomyopathies - diagnosis</topic><topic>Cardiomyopathies - epidemiology</topic><topic>Cardiomyopathies - etiology</topic><topic>Cardiomyopathies - therapy</topic><topic>Cardiovascular Agents - therapeutic use</topic><topic>Disease Susceptibility</topic><topic>Female</topic><topic>Heart Failure - etiology</topic><topic>Heart Transplantation</topic><topic>Hormones - blood</topic><topic>Humans</topic><topic>Hypertension - complications</topic><topic>Incidence</topic><topic>Infant, Newborn</topic><topic>Lactation - drug effects</topic><topic>Pre-Eclampsia - physiopathology</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Cardiovascular - diagnosis</topic><topic>Pregnancy Complications, Cardiovascular - epidemiology</topic><topic>Pregnancy Complications, Cardiovascular - etiology</topic><topic>Pregnancy Complications, Cardiovascular - therapy</topic><topic>Pregnancy, Multiple</topic><topic>Puerperal Disorders - diagnosis</topic><topic>Puerperal Disorders - epidemiology</topic><topic>Puerperal Disorders - etiology</topic><topic>Puerperal Disorders - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arany, Zolt</creatorcontrib><creatorcontrib>Elkayam, Uri</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arany, Zolt</au><au>Elkayam, Uri</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peripartum Cardiomyopathy</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>2016-04-05</date><risdate>2016</risdate><volume>133</volume><issue>14</issue><spage>1397</spage><epage>1409</epage><pages>1397-1409</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><abstract>Peripartum cardiomyopathy is a potentially life-threatening pregnancy-associated disease that typically arises in the peripartum period and is marked by left ventricular dysfunction and heart failure. The disease is relatively uncommon, but its incidence is rising. Women often recover cardiac function, but long-lasting morbidity and mortality are not infrequent. Management of peripartum cardiomyopathy is largely limited to the same neurohormonal antagonists used in other forms of cardiomyopathy, and no proven disease-specific therapies exist yet. Research in the past decade has suggested that peripartum cardiomyopathy is caused by vascular dysfunction, triggered by late-gestational maternal hormones. Most recently, information has also indicated that many cases of peripartum cardiomyopathy have genetic underpinnings. We review here the known epidemiology, clinical presentation, and management of peripartum cardiomyopathy, as well as the current knowledge of the pathophysiology of the disease.</abstract><cop>United States</cop><pub>by the American College of Cardiology Foundation and the American Heart Association, Inc</pub><pmid>27045128</pmid><doi>10.1161/CIRCULATIONAHA.115.020491</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0009-7322 |
| ispartof | Circulation (New York, N.Y.), 2016-04, Vol.133 (14), p.1397-1409 |
| issn | 0009-7322 1524-4539 |
| language | eng |
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| source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Bromocriptine - therapeutic use Cardiomyopathies - diagnosis Cardiomyopathies - epidemiology Cardiomyopathies - etiology Cardiomyopathies - therapy Cardiovascular Agents - therapeutic use Disease Susceptibility Female Heart Failure - etiology Heart Transplantation Hormones - blood Humans Hypertension - complications Incidence Infant, Newborn Lactation - drug effects Pre-Eclampsia - physiopathology Pregnancy Pregnancy Complications, Cardiovascular - diagnosis Pregnancy Complications, Cardiovascular - epidemiology Pregnancy Complications, Cardiovascular - etiology Pregnancy Complications, Cardiovascular - therapy Pregnancy, Multiple Puerperal Disorders - diagnosis Puerperal Disorders - epidemiology Puerperal Disorders - etiology Puerperal Disorders - therapy |
| title | Peripartum Cardiomyopathy |
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