Regional homogeneity changes in patients with primary insomnia
Purpose The study aimed to explore the regional spontaneous activity changes in primary insomnia (PI) patients. Materials and methods Based on the resting-state fMRI datasets acquired from 59 PI patients and 47 healthy controls, a two-sample t-test was performed on individual normalized regional hom...
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| Veröffentlicht in: | European radiology 2016-05, Vol.26 (5), p.1292-1300 |
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| creator | Wang, Tianyue Li, Shumei Jiang, Guihua Lin, Chulan Li, Meng Ma, Xiaofen Zhan, Wenfeng Fang, Jin Li, Liming Li, Cheng Tian, Junzhang |
| description | Purpose
The study aimed to explore the regional spontaneous activity changes in primary insomnia (PI) patients.
Materials and methods
Based on the resting-state fMRI datasets acquired from 59 PI patients and 47 healthy controls, a two-sample t-test was performed on individual normalized regional homogeneity (ReHo) maps. Relationships between abnormal ReHo values and the Pittsburgh Sleep Quality Index (PSQI), the self-rating anxiety scale (SAS) and the self-rating depression scale (SDS) were investigated with Pearson correlation analysis.
Results
In PI patients, we found increased ReHo in the left insula, right anterior cingulate gyrus, bilateral precentral gyrus and left cuneus, as well as decreased ReHo in the right middle cingulate cortex and left fusiform (
p
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| doi_str_mv | 10.1007/s00330-015-3960-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1779021861</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1779021861</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-c91743678654d045ac53aa585fd9f88cb5cd56c4bc87ccf40032c27221cb9f913</originalsourceid><addsrcrecordid>eNp1kMtKxDAUhoMozjj6AG6k4MZN9eTWJBtBBm8gCKLrkKbpTIZexqZF5u3N2FFEcHUW5zv_4f8QOsVwiQHEVQCgFFLAPKUqg5TtoSlmlKQYJNtHU1BUpkIpNkFHIawAQGEmDtGEZJQDp2qKrl_cwreNqZJlW7cL1zjfbxK7NM3ChcQ3ydr03jV9SD58v0zWna9Nt4mL0NaNN8fooDRVcCe7OUNvd7ev84f06fn-cX7zlFoqSJ9ahQWjmZAZZwUwbiynxnDJy0KVUtqc24JnluVWCmtLFnsRSwQh2OaqVJjO0MWYu-7a98GFXtc-WFdVpnHtEDQWQgHBMtui53_QVTt0seEXJWlGGKeRwiNluzaEzpV6V01j0Fu5epSro1y9latZvDnbJQ957Yqfi2-bESAjEOIqCux-vf439RPi04NA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1778362453</pqid></control><display><type>article</type><title>Regional homogeneity changes in patients with primary insomnia</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Wang, Tianyue ; Li, Shumei ; Jiang, Guihua ; Lin, Chulan ; Li, Meng ; Ma, Xiaofen ; Zhan, Wenfeng ; Fang, Jin ; Li, Liming ; Li, Cheng ; Tian, Junzhang</creator><creatorcontrib>Wang, Tianyue ; Li, Shumei ; Jiang, Guihua ; Lin, Chulan ; Li, Meng ; Ma, Xiaofen ; Zhan, Wenfeng ; Fang, Jin ; Li, Liming ; Li, Cheng ; Tian, Junzhang</creatorcontrib><description>Purpose
The study aimed to explore the regional spontaneous activity changes in primary insomnia (PI) patients.
Materials and methods
Based on the resting-state fMRI datasets acquired from 59 PI patients and 47 healthy controls, a two-sample t-test was performed on individual normalized regional homogeneity (ReHo) maps. Relationships between abnormal ReHo values and the Pittsburgh Sleep Quality Index (PSQI), the self-rating anxiety scale (SAS) and the self-rating depression scale (SDS) were investigated with Pearson correlation analysis.
Results
In PI patients, we found increased ReHo in the left insula, right anterior cingulate gyrus, bilateral precentral gyrus and left cuneus, as well as decreased ReHo in the right middle cingulate cortex and left fusiform (
p
< 0.05, AlphaSim-corrected). We also found a significant positive correlation between increased ReHo in the left insula and SAS scores, decreased ReHo in the right middle cingulated cortex and SDS, SAS scores as well as a negative correlation between increased ReHo in the right precentral gyrus and SDS scores (
p
< 0.05).
Conclusions
Our study found abnormal spontaneous activities in multiple brain regions, especially in emotion-related areas in PI patients. Alterative activities in these regions might contribute to an understanding the intrinsic functional architecture of insomnia and its clinical features.
Key Points
•
Regional spontaneous activity changes were detected in PI patients
.
•
Decreased or increased ReHo of some regions was identified in PI patients
.
•
Significant correlations between mean ReHo and SDS scores were found
.</description><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-015-3960-4</identifier><identifier>PMID: 26350539</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Brain ; Cerebral Cortex - pathology ; Diagnostic Radiology ; Female ; Frontal Lobe - pathology ; Head and Neck ; Humans ; Imaging ; Insomnia ; Internal Medicine ; Interventional Radiology ; Magnetic Resonance Imaging - methods ; Male ; Medicine ; Medicine & Public Health ; Metabolism ; Neurobiology ; Neuroradiology ; Physiology ; Radiology ; Sleep ; Sleep Initiation and Maintenance Disorders - diagnosis ; Ultrasound</subject><ispartof>European radiology, 2016-05, Vol.26 (5), p.1292-1300</ispartof><rights>European Society of Radiology 2015</rights><rights>European Society of Radiology 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-c91743678654d045ac53aa585fd9f88cb5cd56c4bc87ccf40032c27221cb9f913</citedby><cites>FETCH-LOGICAL-c372t-c91743678654d045ac53aa585fd9f88cb5cd56c4bc87ccf40032c27221cb9f913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00330-015-3960-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00330-015-3960-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26350539$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Tianyue</creatorcontrib><creatorcontrib>Li, Shumei</creatorcontrib><creatorcontrib>Jiang, Guihua</creatorcontrib><creatorcontrib>Lin, Chulan</creatorcontrib><creatorcontrib>Li, Meng</creatorcontrib><creatorcontrib>Ma, Xiaofen</creatorcontrib><creatorcontrib>Zhan, Wenfeng</creatorcontrib><creatorcontrib>Fang, Jin</creatorcontrib><creatorcontrib>Li, Liming</creatorcontrib><creatorcontrib>Li, Cheng</creatorcontrib><creatorcontrib>Tian, Junzhang</creatorcontrib><title>Regional homogeneity changes in patients with primary insomnia</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><addtitle>Eur Radiol</addtitle><description>Purpose
The study aimed to explore the regional spontaneous activity changes in primary insomnia (PI) patients.
Materials and methods
Based on the resting-state fMRI datasets acquired from 59 PI patients and 47 healthy controls, a two-sample t-test was performed on individual normalized regional homogeneity (ReHo) maps. Relationships between abnormal ReHo values and the Pittsburgh Sleep Quality Index (PSQI), the self-rating anxiety scale (SAS) and the self-rating depression scale (SDS) were investigated with Pearson correlation analysis.
Results
In PI patients, we found increased ReHo in the left insula, right anterior cingulate gyrus, bilateral precentral gyrus and left cuneus, as well as decreased ReHo in the right middle cingulate cortex and left fusiform (
p
< 0.05, AlphaSim-corrected). We also found a significant positive correlation between increased ReHo in the left insula and SAS scores, decreased ReHo in the right middle cingulated cortex and SDS, SAS scores as well as a negative correlation between increased ReHo in the right precentral gyrus and SDS scores (
p
< 0.05).
Conclusions
Our study found abnormal spontaneous activities in multiple brain regions, especially in emotion-related areas in PI patients. Alterative activities in these regions might contribute to an understanding the intrinsic functional architecture of insomnia and its clinical features.
Key Points
•
Regional spontaneous activity changes were detected in PI patients
.
•
Decreased or increased ReHo of some regions was identified in PI patients
.
•
Significant correlations between mean ReHo and SDS scores were found
.</description><subject>Adult</subject><subject>Brain</subject><subject>Cerebral Cortex - pathology</subject><subject>Diagnostic Radiology</subject><subject>Female</subject><subject>Frontal Lobe - pathology</subject><subject>Head and Neck</subject><subject>Humans</subject><subject>Imaging</subject><subject>Insomnia</subject><subject>Internal Medicine</subject><subject>Interventional Radiology</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolism</subject><subject>Neurobiology</subject><subject>Neuroradiology</subject><subject>Physiology</subject><subject>Radiology</subject><subject>Sleep</subject><subject>Sleep Initiation and Maintenance Disorders - diagnosis</subject><subject>Ultrasound</subject><issn>0938-7994</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kMtKxDAUhoMozjj6AG6k4MZN9eTWJBtBBm8gCKLrkKbpTIZexqZF5u3N2FFEcHUW5zv_4f8QOsVwiQHEVQCgFFLAPKUqg5TtoSlmlKQYJNtHU1BUpkIpNkFHIawAQGEmDtGEZJQDp2qKrl_cwreNqZJlW7cL1zjfbxK7NM3ChcQ3ydr03jV9SD58v0zWna9Nt4mL0NaNN8fooDRVcCe7OUNvd7ev84f06fn-cX7zlFoqSJ9ahQWjmZAZZwUwbiynxnDJy0KVUtqc24JnluVWCmtLFnsRSwQh2OaqVJjO0MWYu-7a98GFXtc-WFdVpnHtEDQWQgHBMtui53_QVTt0seEXJWlGGKeRwiNluzaEzpV6V01j0Fu5epSro1y9latZvDnbJQ957Yqfi2-bESAjEOIqCux-vf439RPi04NA</recordid><startdate>20160501</startdate><enddate>20160501</enddate><creator>Wang, Tianyue</creator><creator>Li, Shumei</creator><creator>Jiang, Guihua</creator><creator>Lin, Chulan</creator><creator>Li, Meng</creator><creator>Ma, Xiaofen</creator><creator>Zhan, Wenfeng</creator><creator>Fang, Jin</creator><creator>Li, Liming</creator><creator>Li, Cheng</creator><creator>Tian, Junzhang</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20160501</creationdate><title>Regional homogeneity changes in patients with primary insomnia</title><author>Wang, Tianyue ; Li, Shumei ; Jiang, Guihua ; Lin, Chulan ; Li, Meng ; Ma, Xiaofen ; Zhan, Wenfeng ; Fang, Jin ; Li, Liming ; Li, Cheng ; Tian, Junzhang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-c91743678654d045ac53aa585fd9f88cb5cd56c4bc87ccf40032c27221cb9f913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Brain</topic><topic>Cerebral Cortex - pathology</topic><topic>Diagnostic Radiology</topic><topic>Female</topic><topic>Frontal Lobe - pathology</topic><topic>Head and Neck</topic><topic>Humans</topic><topic>Imaging</topic><topic>Insomnia</topic><topic>Internal Medicine</topic><topic>Interventional Radiology</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolism</topic><topic>Neurobiology</topic><topic>Neuroradiology</topic><topic>Physiology</topic><topic>Radiology</topic><topic>Sleep</topic><topic>Sleep Initiation and Maintenance Disorders - diagnosis</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Tianyue</creatorcontrib><creatorcontrib>Li, Shumei</creatorcontrib><creatorcontrib>Jiang, Guihua</creatorcontrib><creatorcontrib>Lin, Chulan</creatorcontrib><creatorcontrib>Li, Meng</creatorcontrib><creatorcontrib>Ma, Xiaofen</creatorcontrib><creatorcontrib>Zhan, Wenfeng</creatorcontrib><creatorcontrib>Fang, Jin</creatorcontrib><creatorcontrib>Li, Liming</creatorcontrib><creatorcontrib>Li, Cheng</creatorcontrib><creatorcontrib>Tian, Junzhang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Tianyue</au><au>Li, Shumei</au><au>Jiang, Guihua</au><au>Lin, Chulan</au><au>Li, Meng</au><au>Ma, Xiaofen</au><au>Zhan, Wenfeng</au><au>Fang, Jin</au><au>Li, Liming</au><au>Li, Cheng</au><au>Tian, Junzhang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regional homogeneity changes in patients with primary insomnia</atitle><jtitle>European radiology</jtitle><stitle>Eur Radiol</stitle><addtitle>Eur Radiol</addtitle><date>2016-05-01</date><risdate>2016</risdate><volume>26</volume><issue>5</issue><spage>1292</spage><epage>1300</epage><pages>1292-1300</pages><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>Purpose
The study aimed to explore the regional spontaneous activity changes in primary insomnia (PI) patients.
Materials and methods
Based on the resting-state fMRI datasets acquired from 59 PI patients and 47 healthy controls, a two-sample t-test was performed on individual normalized regional homogeneity (ReHo) maps. Relationships between abnormal ReHo values and the Pittsburgh Sleep Quality Index (PSQI), the self-rating anxiety scale (SAS) and the self-rating depression scale (SDS) were investigated with Pearson correlation analysis.
Results
In PI patients, we found increased ReHo in the left insula, right anterior cingulate gyrus, bilateral precentral gyrus and left cuneus, as well as decreased ReHo in the right middle cingulate cortex and left fusiform (
p
< 0.05, AlphaSim-corrected). We also found a significant positive correlation between increased ReHo in the left insula and SAS scores, decreased ReHo in the right middle cingulated cortex and SDS, SAS scores as well as a negative correlation between increased ReHo in the right precentral gyrus and SDS scores (
p
< 0.05).
Conclusions
Our study found abnormal spontaneous activities in multiple brain regions, especially in emotion-related areas in PI patients. Alterative activities in these regions might contribute to an understanding the intrinsic functional architecture of insomnia and its clinical features.
Key Points
•
Regional spontaneous activity changes were detected in PI patients
.
•
Decreased or increased ReHo of some regions was identified in PI patients
.
•
Significant correlations between mean ReHo and SDS scores were found
.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>26350539</pmid><doi>10.1007/s00330-015-3960-4</doi><tpages>9</tpages></addata></record> |
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| ispartof | European radiology, 2016-05, Vol.26 (5), p.1292-1300 |
| issn | 0938-7994 1432-1084 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Adult Brain Cerebral Cortex - pathology Diagnostic Radiology Female Frontal Lobe - pathology Head and Neck Humans Imaging Insomnia Internal Medicine Interventional Radiology Magnetic Resonance Imaging - methods Male Medicine Medicine & Public Health Metabolism Neurobiology Neuroradiology Physiology Radiology Sleep Sleep Initiation and Maintenance Disorders - diagnosis Ultrasound |
| title | Regional homogeneity changes in patients with primary insomnia |
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