Additive clinical value of serum brain-derived neurotrophic factor for prediction of chronic heart failure outcome
The importance of the central nervous system in cardiovascular events has been recognized. Recently, brain-derived neurotrophic factor (BDNF), a member of the neurotrophic factor family, is involved in depression mechanisms and also in stress and anxiety. Because BDNF is reported about cardioprotect...
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| Veröffentlicht in: | Heart and vessels 2016-04, Vol.31 (4), p.535-544 |
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| creator | Kadowaki, Shinpei Shishido, Tetsuro Honda, Yuki Narumi, Taro Otaki, Yoichiro Kinoshita, Daisuke Nishiyama, Satoshi Takahashi, Hiroki Arimoto, Takanori Miyamoto, Takuya Watanabe, Tetsu Kubota, Isao |
| description | The importance of the central nervous system in cardiovascular events has been recognized. Recently, brain-derived neurotrophic factor (BDNF), a member of the neurotrophic factor family, is involved in depression mechanisms and also in stress and anxiety. Because BDNF is reported about cardioprotective role, we elucidated whether BDNF is associated with cardiovascular events in patients with chronic heart failure (CHF). We examined serum BDNF levels in 134 patients with CHF and 23 control subjects. The patients were followed to register cardiac events for a median of 426 days. BDNF was significantly lower in CHF patients than in control subjects (25.8 ± 8.4 vs 14.7 ± 8.4,
P
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| doi_str_mv | 10.1007/s00380-015-0628-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1779021806</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1779021806</sourcerecordid><originalsourceid>FETCH-LOGICAL-c462t-575372758c521703adce06000e0ae1c025cbb7b7055125fb81f93816038249f93</originalsourceid><addsrcrecordid>eNp1kUtr3TAQhUVpaW6S_oBuiqCbbtyO5KuHlyH0EQh0k6yFLI97FWzrdmQF-u8jc9NSCkUIadB3joY5jL0V8FEAmE8ZoLXQgFANaGkb_YLthK6VVKZ9yXbQCWhsK80ZO8_5ASrYie41O5NKC73v7I7R1TDENT4iD1NcYvATf_RTQZ5GnpHKzHvycWkGpAoNfMFCaaV0PMTARx_WRHys-0g4xLDGtGzKcKBUzfgBPa0Vi1OhalnWkGa8ZK9GP2V883xesPsvn--uvzW337_eXF_dNmGv5dooo1ojjbJBSWGg9UNA0ACA4FEEkCr0vekNKCWkGnsrxq61QteRyH1X7xfsw8n3SOlnwby6OeaA0-QXTCU7YUwHUljQFX3_D_qQCi21u42yrZZ1VUqcqEApZ8LRHSnOnn45AW4LxJ0CcXXObgvEbZp3z86ln3H4o_idQAXkCcj1afmB9NfX_3V9AuCdlY8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1778362626</pqid></control><display><type>article</type><title>Additive clinical value of serum brain-derived neurotrophic factor for prediction of chronic heart failure outcome</title><source>MEDLINE</source><source>SpringerLink (Online service)</source><creator>Kadowaki, Shinpei ; Shishido, Tetsuro ; Honda, Yuki ; Narumi, Taro ; Otaki, Yoichiro ; Kinoshita, Daisuke ; Nishiyama, Satoshi ; Takahashi, Hiroki ; Arimoto, Takanori ; Miyamoto, Takuya ; Watanabe, Tetsu ; Kubota, Isao</creator><creatorcontrib>Kadowaki, Shinpei ; Shishido, Tetsuro ; Honda, Yuki ; Narumi, Taro ; Otaki, Yoichiro ; Kinoshita, Daisuke ; Nishiyama, Satoshi ; Takahashi, Hiroki ; Arimoto, Takanori ; Miyamoto, Takuya ; Watanabe, Tetsu ; Kubota, Isao</creatorcontrib><description>The importance of the central nervous system in cardiovascular events has been recognized. Recently, brain-derived neurotrophic factor (BDNF), a member of the neurotrophic factor family, is involved in depression mechanisms and also in stress and anxiety. Because BDNF is reported about cardioprotective role, we elucidated whether BDNF is associated with cardiovascular events in patients with chronic heart failure (CHF). We examined serum BDNF levels in 134 patients with CHF and 23 control subjects. The patients were followed to register cardiac events for a median of 426 days. BDNF was significantly lower in CHF patients than in control subjects (25.8 ± 8.4 vs 14.7 ± 8.4,
P
< 0.0001). Serum BDNF was also lower in patients with cardiac events than in event-free patients (16.1 ± 8.0 vs 12.5 ± 8.5,
P
< 0.0001). The cutoff value of BDNF was determined by performing receiver operating characteristic curve analysis. Kaplan–Meier analysis demonstrated that patients with low levels of BDNF experienced higher rates of cardiac events than those with high levels of BDNF. Multivariate Cox hazard analysis demonstrated that low BDNF levels (≤12.4 ng/mL) were an independent prognostic factor for cardiac events (hazard ratio 2.932, 95 % confidence interval 1.622–5.301;
P
= 0.0004). Adding levels of BDNF to the model with BNP levels, age, and eGFR for the prediction of cardiac events yielded significant net reclassification improvement of 0.429 (
P
< 0.001) and an integrated discrimination improvement of 0.101 (
P
< 0.001). Low serum BDNF levels were found in patients with CHF, and these levels were found to be independently associated with an increased risk of cardiac events.</description><identifier>ISSN: 0910-8327</identifier><identifier>EISSN: 1615-2573</identifier><identifier>DOI: 10.1007/s00380-015-0628-6</identifier><identifier>PMID: 25616498</identifier><identifier>CODEN: HEVEEO</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Aged ; Biomarkers - blood ; Biomedical Engineering and Bioengineering ; Brain-derived neurotrophic factor ; Brain-Derived Neurotrophic Factor - blood ; Cardiac Surgery ; Cardiology ; Disease Progression ; Echocardiography ; Enzyme-Linked Immunosorbent Assay ; Female ; Heart failure ; Heart Failure - blood ; Heart Failure - diagnosis ; Heart Failure - epidemiology ; Heart Ventricles - diagnostic imaging ; Humans ; Incidence ; Japan - epidemiology ; Kaplan-Meier Estimate ; Male ; Medical prognosis ; Medicine ; Medicine & Public Health ; Original Article ; Prognosis ; Radiography, Thoracic ; Retrospective Studies ; Risk Factors ; ROC Curve ; Survival Rate - trends ; Vascular Surgery</subject><ispartof>Heart and vessels, 2016-04, Vol.31 (4), p.535-544</ispartof><rights>Springer Japan 2015</rights><rights>Springer Japan 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c462t-575372758c521703adce06000e0ae1c025cbb7b7055125fb81f93816038249f93</citedby><cites>FETCH-LOGICAL-c462t-575372758c521703adce06000e0ae1c025cbb7b7055125fb81f93816038249f93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00380-015-0628-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00380-015-0628-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25616498$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kadowaki, Shinpei</creatorcontrib><creatorcontrib>Shishido, Tetsuro</creatorcontrib><creatorcontrib>Honda, Yuki</creatorcontrib><creatorcontrib>Narumi, Taro</creatorcontrib><creatorcontrib>Otaki, Yoichiro</creatorcontrib><creatorcontrib>Kinoshita, Daisuke</creatorcontrib><creatorcontrib>Nishiyama, Satoshi</creatorcontrib><creatorcontrib>Takahashi, Hiroki</creatorcontrib><creatorcontrib>Arimoto, Takanori</creatorcontrib><creatorcontrib>Miyamoto, Takuya</creatorcontrib><creatorcontrib>Watanabe, Tetsu</creatorcontrib><creatorcontrib>Kubota, Isao</creatorcontrib><title>Additive clinical value of serum brain-derived neurotrophic factor for prediction of chronic heart failure outcome</title><title>Heart and vessels</title><addtitle>Heart Vessels</addtitle><addtitle>Heart Vessels</addtitle><description>The importance of the central nervous system in cardiovascular events has been recognized. Recently, brain-derived neurotrophic factor (BDNF), a member of the neurotrophic factor family, is involved in depression mechanisms and also in stress and anxiety. Because BDNF is reported about cardioprotective role, we elucidated whether BDNF is associated with cardiovascular events in patients with chronic heart failure (CHF). We examined serum BDNF levels in 134 patients with CHF and 23 control subjects. The patients were followed to register cardiac events for a median of 426 days. BDNF was significantly lower in CHF patients than in control subjects (25.8 ± 8.4 vs 14.7 ± 8.4,
P
< 0.0001). Serum BDNF was also lower in patients with cardiac events than in event-free patients (16.1 ± 8.0 vs 12.5 ± 8.5,
P
< 0.0001). The cutoff value of BDNF was determined by performing receiver operating characteristic curve analysis. Kaplan–Meier analysis demonstrated that patients with low levels of BDNF experienced higher rates of cardiac events than those with high levels of BDNF. Multivariate Cox hazard analysis demonstrated that low BDNF levels (≤12.4 ng/mL) were an independent prognostic factor for cardiac events (hazard ratio 2.932, 95 % confidence interval 1.622–5.301;
P
= 0.0004). Adding levels of BDNF to the model with BNP levels, age, and eGFR for the prediction of cardiac events yielded significant net reclassification improvement of 0.429 (
P
< 0.001) and an integrated discrimination improvement of 0.101 (
P
< 0.001). Low serum BDNF levels were found in patients with CHF, and these levels were found to be independently associated with an increased risk of cardiac events.</description><subject>Aged</subject><subject>Biomarkers - blood</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Brain-derived neurotrophic factor</subject><subject>Brain-Derived Neurotrophic Factor - blood</subject><subject>Cardiac Surgery</subject><subject>Cardiology</subject><subject>Disease Progression</subject><subject>Echocardiography</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Heart failure</subject><subject>Heart Failure - blood</subject><subject>Heart Failure - diagnosis</subject><subject>Heart Failure - epidemiology</subject><subject>Heart Ventricles - diagnostic imaging</subject><subject>Humans</subject><subject>Incidence</subject><subject>Japan - epidemiology</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><subject>Prognosis</subject><subject>Radiography, Thoracic</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>ROC Curve</subject><subject>Survival Rate - trends</subject><subject>Vascular Surgery</subject><issn>0910-8327</issn><issn>1615-2573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kUtr3TAQhUVpaW6S_oBuiqCbbtyO5KuHlyH0EQh0k6yFLI97FWzrdmQF-u8jc9NSCkUIadB3joY5jL0V8FEAmE8ZoLXQgFANaGkb_YLthK6VVKZ9yXbQCWhsK80ZO8_5ASrYie41O5NKC73v7I7R1TDENT4iD1NcYvATf_RTQZ5GnpHKzHvycWkGpAoNfMFCaaV0PMTARx_WRHys-0g4xLDGtGzKcKBUzfgBPa0Vi1OhalnWkGa8ZK9GP2V883xesPsvn--uvzW337_eXF_dNmGv5dooo1ojjbJBSWGg9UNA0ACA4FEEkCr0vekNKCWkGnsrxq61QteRyH1X7xfsw8n3SOlnwby6OeaA0-QXTCU7YUwHUljQFX3_D_qQCi21u42yrZZ1VUqcqEApZ8LRHSnOnn45AW4LxJ0CcXXObgvEbZp3z86ln3H4o_idQAXkCcj1afmB9NfX_3V9AuCdlY8</recordid><startdate>20160401</startdate><enddate>20160401</enddate><creator>Kadowaki, Shinpei</creator><creator>Shishido, Tetsuro</creator><creator>Honda, Yuki</creator><creator>Narumi, Taro</creator><creator>Otaki, Yoichiro</creator><creator>Kinoshita, Daisuke</creator><creator>Nishiyama, Satoshi</creator><creator>Takahashi, Hiroki</creator><creator>Arimoto, Takanori</creator><creator>Miyamoto, Takuya</creator><creator>Watanabe, Tetsu</creator><creator>Kubota, Isao</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20160401</creationdate><title>Additive clinical value of serum brain-derived neurotrophic factor for prediction of chronic heart failure outcome</title><author>Kadowaki, Shinpei ; Shishido, Tetsuro ; Honda, Yuki ; Narumi, Taro ; Otaki, Yoichiro ; Kinoshita, Daisuke ; Nishiyama, Satoshi ; Takahashi, Hiroki ; Arimoto, Takanori ; Miyamoto, Takuya ; Watanabe, Tetsu ; Kubota, Isao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-575372758c521703adce06000e0ae1c025cbb7b7055125fb81f93816038249f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Biomarkers - blood</topic><topic>Biomedical Engineering and Bioengineering</topic><topic>Brain-derived neurotrophic factor</topic><topic>Brain-Derived Neurotrophic Factor - blood</topic><topic>Cardiac Surgery</topic><topic>Cardiology</topic><topic>Disease Progression</topic><topic>Echocardiography</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Heart failure</topic><topic>Heart Failure - blood</topic><topic>Heart Failure - diagnosis</topic><topic>Heart Failure - epidemiology</topic><topic>Heart Ventricles - diagnostic imaging</topic><topic>Humans</topic><topic>Incidence</topic><topic>Japan - epidemiology</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article</topic><topic>Prognosis</topic><topic>Radiography, Thoracic</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>ROC Curve</topic><topic>Survival Rate - trends</topic><topic>Vascular Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kadowaki, Shinpei</creatorcontrib><creatorcontrib>Shishido, Tetsuro</creatorcontrib><creatorcontrib>Honda, Yuki</creatorcontrib><creatorcontrib>Narumi, Taro</creatorcontrib><creatorcontrib>Otaki, Yoichiro</creatorcontrib><creatorcontrib>Kinoshita, Daisuke</creatorcontrib><creatorcontrib>Nishiyama, Satoshi</creatorcontrib><creatorcontrib>Takahashi, Hiroki</creatorcontrib><creatorcontrib>Arimoto, Takanori</creatorcontrib><creatorcontrib>Miyamoto, Takuya</creatorcontrib><creatorcontrib>Watanabe, Tetsu</creatorcontrib><creatorcontrib>Kubota, Isao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Research Library</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Heart and vessels</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kadowaki, Shinpei</au><au>Shishido, Tetsuro</au><au>Honda, Yuki</au><au>Narumi, Taro</au><au>Otaki, Yoichiro</au><au>Kinoshita, Daisuke</au><au>Nishiyama, Satoshi</au><au>Takahashi, Hiroki</au><au>Arimoto, Takanori</au><au>Miyamoto, Takuya</au><au>Watanabe, Tetsu</au><au>Kubota, Isao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Additive clinical value of serum brain-derived neurotrophic factor for prediction of chronic heart failure outcome</atitle><jtitle>Heart and vessels</jtitle><stitle>Heart Vessels</stitle><addtitle>Heart Vessels</addtitle><date>2016-04-01</date><risdate>2016</risdate><volume>31</volume><issue>4</issue><spage>535</spage><epage>544</epage><pages>535-544</pages><issn>0910-8327</issn><eissn>1615-2573</eissn><coden>HEVEEO</coden><abstract>The importance of the central nervous system in cardiovascular events has been recognized. Recently, brain-derived neurotrophic factor (BDNF), a member of the neurotrophic factor family, is involved in depression mechanisms and also in stress and anxiety. Because BDNF is reported about cardioprotective role, we elucidated whether BDNF is associated with cardiovascular events in patients with chronic heart failure (CHF). We examined serum BDNF levels in 134 patients with CHF and 23 control subjects. The patients were followed to register cardiac events for a median of 426 days. BDNF was significantly lower in CHF patients than in control subjects (25.8 ± 8.4 vs 14.7 ± 8.4,
P
< 0.0001). Serum BDNF was also lower in patients with cardiac events than in event-free patients (16.1 ± 8.0 vs 12.5 ± 8.5,
P
< 0.0001). The cutoff value of BDNF was determined by performing receiver operating characteristic curve analysis. Kaplan–Meier analysis demonstrated that patients with low levels of BDNF experienced higher rates of cardiac events than those with high levels of BDNF. Multivariate Cox hazard analysis demonstrated that low BDNF levels (≤12.4 ng/mL) were an independent prognostic factor for cardiac events (hazard ratio 2.932, 95 % confidence interval 1.622–5.301;
P
= 0.0004). Adding levels of BDNF to the model with BNP levels, age, and eGFR for the prediction of cardiac events yielded significant net reclassification improvement of 0.429 (
P
< 0.001) and an integrated discrimination improvement of 0.101 (
P
< 0.001). Low serum BDNF levels were found in patients with CHF, and these levels were found to be independently associated with an increased risk of cardiac events.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>25616498</pmid><doi>10.1007/s00380-015-0628-6</doi><tpages>10</tpages></addata></record> |
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| subjects | Aged Biomarkers - blood Biomedical Engineering and Bioengineering Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - blood Cardiac Surgery Cardiology Disease Progression Echocardiography Enzyme-Linked Immunosorbent Assay Female Heart failure Heart Failure - blood Heart Failure - diagnosis Heart Failure - epidemiology Heart Ventricles - diagnostic imaging Humans Incidence Japan - epidemiology Kaplan-Meier Estimate Male Medical prognosis Medicine Medicine & Public Health Original Article Prognosis Radiography, Thoracic Retrospective Studies Risk Factors ROC Curve Survival Rate - trends Vascular Surgery |
| title | Additive clinical value of serum brain-derived neurotrophic factor for prediction of chronic heart failure outcome |
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