Histone modifications patterns in tissues and tumours from acute promyelocytic leukemia xenograft model in response to combined epigenetic therapy

Abstract Xenograft models are suitable for in vivo study of leukemia’s pathogenesis and the preclinical development of anti-leukemia agents but understanding of epigenetic regulatory mechanisms linking to adult cell functions in pathological conditions during different in vivo treatments is yet unkn...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biomedicine & pharmacotherapy 2016-04, Vol.79, p.62-70
Hauptverfasser:	Valiulienė, Giedrė, Treigytė, Gražina, Savickienė, Jūratė, Matuzevičius, Dalius, Alksnė, Milda, Jarašienė-Burinskaja, Rasa, Bukelskienė, Virginija, Navakauskas, Dalius, Navakauskienė, Rūta
Format:	Artikel
Sprache:	eng
Schlagworte:	3-DZNeaplanocin A Acute promyelocytic leukemia Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Antineoplastic Combined Chemotherapy Protocols - pharmacology Antineoplastic Combined Chemotherapy Protocols - therapeutic use Belinostat Brain - drug effects Brain - metabolism Cell Line, Tumor Epigenesis, Genetic - drug effects Female Histone modifications Histones - metabolism Humans Hydroxamic Acids - pharmacology Hydroxamic Acids - therapeutic use Internal Medicine Leukemia, Promyelocytic, Acute - drug therapy Leukemia, Promyelocytic, Acute - genetics Leukemia, Promyelocytic, Acute - metabolism Liver - drug effects Liver - metabolism Male Medical Education Mice Organ Specificity - drug effects Protein Processing, Post-Translational - drug effects Sulfonamides - pharmacology Sulfonamides - therapeutic use Tretinoin - pharmacology Tretinoin - therapeutic use WT1 WT1 Proteins - metabolism Xenograft Model Antitumor Assays
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!