Moderate alcohol consumption diminishes the development of non-alcoholic fatty liver disease (NAFLD) in ob/ob mice

Purpose Using ob / ob mice as a model of non-alcoholic fatty liver disease (NAFLD), we investigated the effect of moderate alcohol intake on the development of NAFLD and molecular mechanisms involved. Methods Ob / ob mice were fed water or ethanol solution (2.5 g/kg body weight/day) for 6 weeks, and...

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Veröffentlicht in:	European journal of nutrition 2016-04, Vol.55 (3), p.1153-1164
Hauptverfasser:	Kanuri, Giridhar, Landmann, Marianne, Priebs, Josephine, Spruss, Astrid, Löscher, Marina, Ziegenhardt, Doreen, Röhl, Carolin, Degen, Christian, Bergheim, Ina
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Adiponectin - metabolism Alcohol Drinking Animals Body Weight Caspase 9 - metabolism Cell Line Chemistry Chemistry and Materials Science Cholesterol, HDL - blood Cholesterol, LDL - blood Ethanol - administration & dosage Fatty Acids, Nonesterified - blood Insulin - blood Intra-Abdominal Fat - metabolism Lipid Metabolism Liver - metabolism Male Mice Mice, Obese Non-alcoholic Fatty Liver Disease - prevention & control Nutrition Original Contribution Plasminogen Activator Inhibitor 1 - metabolism Signal Transduction Sirtuin 1 - metabolism Triglycerides - blood Tumor Necrosis Factor-alpha - metabolism
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