Inhibitory Effects of Retinol Are Greater than Retinoic Acid on the Growth and Adhesion of Human Refractory Cancer Cells
Vitamin A constituents include retinal, which plays a role in vision, and retinoic acid (RA), which has been used in the therapy of human acute promyelocytic leukemia. However, the effects on cancer of retinol (Rol) and its ester, retinyl palmitate (RP) are not known well. In the current study, we e...
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| Veröffentlicht in: | Biological & pharmaceutical bulletin 2016/04/01, Vol.39(4), pp.636-640 |
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| creator | Li, Chuan Imai, Masahiko Matsuura, Tomokazu Hasegawa, Shinya Yamasaki, Masahiro Takahashi, Noriko |
| description | Vitamin A constituents include retinal, which plays a role in vision, and retinoic acid (RA), which has been used in the therapy of human acute promyelocytic leukemia. However, the effects on cancer of retinol (Rol) and its ester, retinyl palmitate (RP) are not known well. In the current study, we examined the effects of these agents on proliferation and adhesion of various cancer cells. Rol exhibited dose-dependent inhibition of the proliferation of human refractory and prostate cancer cells, while RA and RP showed little or no effect. In contrast, RA inhibited the growth of human breast cancer cells to a greater extent than Rol at low concentrations, but not at high concentrations. Rol suppressed adhesion of refractory and prostate cancer cells to a greater extent than RA, while it suppressed adhesion of breast cancer cells as well as RA and of JHP-1 cells less effectively than RA. These results indicate that Rol is a potent suppressor of cancer cell growth and adhesion, which are both linked to metastasis and tumor progression. Rol might be useful for the clinical treatment of cancer. |
| doi_str_mv | 10.1248/bpb.b15-00794 |
| format | Article |
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However, the effects on cancer of retinol (Rol) and its ester, retinyl palmitate (RP) are not known well. In the current study, we examined the effects of these agents on proliferation and adhesion of various cancer cells. Rol exhibited dose-dependent inhibition of the proliferation of human refractory and prostate cancer cells, while RA and RP showed little or no effect. In contrast, RA inhibited the growth of human breast cancer cells to a greater extent than Rol at low concentrations, but not at high concentrations. Rol suppressed adhesion of refractory and prostate cancer cells to a greater extent than RA, while it suppressed adhesion of breast cancer cells as well as RA and of JHP-1 cells less effectively than RA. These results indicate that Rol is a potent suppressor of cancer cell growth and adhesion, which are both linked to metastasis and tumor progression. Rol might be useful for the clinical treatment of cancer.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.b15-00794</identifier><identifier>PMID: 26822412</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>anti-cancer ; Antineoplastic Agents - pharmacology ; Cell Adhesion - drug effects ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Drug Resistance, Neoplasm - drug effects ; Humans ; Neoplasms - drug therapy ; retinoic acid ; retinol ; retinyl palmitate ; Tretinoin - pharmacology ; vitamin A ; Vitamin A - analogs & derivatives ; Vitamin A - pharmacology</subject><ispartof>Biological and Pharmaceutical Bulletin, 2016/04/01, Vol.39(4), pp.636-640</ispartof><rights>2016 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c702t-83b02f8d4069d7bfef4e611239615a65f794b93e0d69f8c24db694944fc708243</citedby><cites>FETCH-LOGICAL-c702t-83b02f8d4069d7bfef4e611239615a65f794b93e0d69f8c24db694944fc708243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26822412$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Chuan</creatorcontrib><creatorcontrib>Imai, Masahiko</creatorcontrib><creatorcontrib>Matsuura, Tomokazu</creatorcontrib><creatorcontrib>Hasegawa, Shinya</creatorcontrib><creatorcontrib>Yamasaki, Masahiro</creatorcontrib><creatorcontrib>Takahashi, Noriko</creatorcontrib><creatorcontrib>Hoshi University</creatorcontrib><creatorcontrib>Institute of Medicinal Chemistry</creatorcontrib><creatorcontrib>bDepartment of Laboratory Medicine</creatorcontrib><creatorcontrib>The Jikei University School of Medicine</creatorcontrib><creatorcontrib>aLaboratory of Physiological Chemistry</creatorcontrib><title>Inhibitory Effects of Retinol Are Greater than Retinoic Acid on the Growth and Adhesion of Human Refractory Cancer Cells</title><title>Biological & pharmaceutical bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>Vitamin A constituents include retinal, which plays a role in vision, and retinoic acid (RA), which has been used in the therapy of human acute promyelocytic leukemia. However, the effects on cancer of retinol (Rol) and its ester, retinyl palmitate (RP) are not known well. In the current study, we examined the effects of these agents on proliferation and adhesion of various cancer cells. Rol exhibited dose-dependent inhibition of the proliferation of human refractory and prostate cancer cells, while RA and RP showed little or no effect. In contrast, RA inhibited the growth of human breast cancer cells to a greater extent than Rol at low concentrations, but not at high concentrations. Rol suppressed adhesion of refractory and prostate cancer cells to a greater extent than RA, while it suppressed adhesion of breast cancer cells as well as RA and of JHP-1 cells less effectively than RA. These results indicate that Rol is a potent suppressor of cancer cell growth and adhesion, which are both linked to metastasis and tumor progression. Rol might be useful for the clinical treatment of cancer.</description><subject>anti-cancer</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Cell Adhesion - drug effects</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>Drug Resistance, Neoplasm - drug effects</subject><subject>Humans</subject><subject>Neoplasms - drug therapy</subject><subject>retinoic acid</subject><subject>retinol</subject><subject>retinyl palmitate</subject><subject>Tretinoin - pharmacology</subject><subject>vitamin A</subject><subject>Vitamin A - analogs & derivatives</subject><subject>Vitamin A - pharmacology</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkcFv2yAUxtG0ac26HXedLO2yizvAGJtjFHVppUqVpu2MAMNM5EAGWGv_-73EWSb1AAje733vQx9CHwm-IZT1X_VB32jS1hh3gr1CK9Kwrm4paV-jFRakrzlp-yv0LucdBgbT5i26orynlBG6Qk_3YfTal5ieq1vnrCm5iq76bosPcarWyVbbZFWxqSqjCueCN9Xa-KGKAV6PRPxTxkqFoVoPo80e3kHkbt6fOlxS5jRgo4IBoY2dpvwevXFqyvbD-bxGP7_d_tjc1Q-P2_vN-qE24LXUfaMxdf3AMBdDp511zHJCaCPgX4q3Dn6tRWPxwIXrDWWD5oIJxhz095Q11-jLontI8fdsc5F7nw04UMHGOUvSdX2HO04EoJ9foLs4pwDuFqprBe-BqhfKpJhzsk4ekt-r9CwJlsdIJEQiIRJ5igT4T2fVWe_tcKH_ZQDAdgGg6o2aYph8sP9nm9xpH6coKSYcRBuBmcQUFm_gzhmmnEHqBJQ2i9IuF_XLXkapVLyZ7MlYIyQ7bheDl6oZVZI2NH8B2I20MQ</recordid><startdate>20160401</startdate><enddate>20160401</enddate><creator>Li, Chuan</creator><creator>Imai, Masahiko</creator><creator>Matsuura, Tomokazu</creator><creator>Hasegawa, Shinya</creator><creator>Yamasaki, Masahiro</creator><creator>Takahashi, Noriko</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20160401</creationdate><title>Inhibitory Effects of Retinol Are Greater than Retinoic Acid on the Growth and Adhesion of Human Refractory Cancer Cells</title><author>Li, Chuan ; Imai, Masahiko ; Matsuura, Tomokazu ; Hasegawa, Shinya ; Yamasaki, Masahiro ; Takahashi, Noriko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c702t-83b02f8d4069d7bfef4e611239615a65f794b93e0d69f8c24db694944fc708243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>anti-cancer</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Cell Adhesion - drug effects</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation - drug effects</topic><topic>Drug Resistance, Neoplasm - drug effects</topic><topic>Humans</topic><topic>Neoplasms - drug therapy</topic><topic>retinoic acid</topic><topic>retinol</topic><topic>retinyl palmitate</topic><topic>Tretinoin - pharmacology</topic><topic>vitamin A</topic><topic>Vitamin A - analogs & derivatives</topic><topic>Vitamin A - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Chuan</creatorcontrib><creatorcontrib>Imai, Masahiko</creatorcontrib><creatorcontrib>Matsuura, Tomokazu</creatorcontrib><creatorcontrib>Hasegawa, Shinya</creatorcontrib><creatorcontrib>Yamasaki, Masahiro</creatorcontrib><creatorcontrib>Takahashi, Noriko</creatorcontrib><creatorcontrib>Hoshi University</creatorcontrib><creatorcontrib>Institute of Medicinal Chemistry</creatorcontrib><creatorcontrib>bDepartment of Laboratory Medicine</creatorcontrib><creatorcontrib>The Jikei University School of Medicine</creatorcontrib><creatorcontrib>aLaboratory of Physiological Chemistry</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biological & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Chuan</au><au>Imai, Masahiko</au><au>Matsuura, Tomokazu</au><au>Hasegawa, Shinya</au><au>Yamasaki, Masahiro</au><au>Takahashi, Noriko</au><aucorp>Hoshi University</aucorp><aucorp>Institute of Medicinal Chemistry</aucorp><aucorp>bDepartment of Laboratory Medicine</aucorp><aucorp>The Jikei University School of Medicine</aucorp><aucorp>aLaboratory of Physiological Chemistry</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibitory Effects of Retinol Are Greater than Retinoic Acid on the Growth and Adhesion of Human Refractory Cancer Cells</atitle><jtitle>Biological & pharmaceutical bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>2016-04-01</date><risdate>2016</risdate><volume>39</volume><issue>4</issue><spage>636</spage><epage>640</epage><pages>636-640</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>Vitamin A constituents include retinal, which plays a role in vision, and retinoic acid (RA), which has been used in the therapy of human acute promyelocytic leukemia. However, the effects on cancer of retinol (Rol) and its ester, retinyl palmitate (RP) are not known well. In the current study, we examined the effects of these agents on proliferation and adhesion of various cancer cells. Rol exhibited dose-dependent inhibition of the proliferation of human refractory and prostate cancer cells, while RA and RP showed little or no effect. In contrast, RA inhibited the growth of human breast cancer cells to a greater extent than Rol at low concentrations, but not at high concentrations. Rol suppressed adhesion of refractory and prostate cancer cells to a greater extent than RA, while it suppressed adhesion of breast cancer cells as well as RA and of JHP-1 cells less effectively than RA. These results indicate that Rol is a potent suppressor of cancer cell growth and adhesion, which are both linked to metastasis and tumor progression. Rol might be useful for the clinical treatment of cancer.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>26822412</pmid><doi>10.1248/bpb.b15-00794</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | anti-cancer Antineoplastic Agents - pharmacology Cell Adhesion - drug effects Cell Line, Tumor Cell Proliferation - drug effects Drug Resistance, Neoplasm - drug effects Humans Neoplasms - drug therapy retinoic acid retinol retinyl palmitate Tretinoin - pharmacology vitamin A Vitamin A - analogs & derivatives Vitamin A - pharmacology |
| title | Inhibitory Effects of Retinol Are Greater than Retinoic Acid on the Growth and Adhesion of Human Refractory Cancer Cells |
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