Increased oxidative damage to DNA in ALS patients

Although the cause of amyotrophic lateral sclerosis (ALS) is unknown, substantial evidence indicates that oxidative toxicity is associated with neuronal death in this disease. We examined levels of a well-established marker of oxidative damage to DNA, 8-hydroxy-2′-deoxyguanosine (8OH2′dG) in plasma,...

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Veröffentlicht in:	Free radical biology & medicine 2000-10, Vol.29 (7), p.652-658
Hauptverfasser:	Bogdanov, Mikhail, Brown, Robert H, Matson, Wayne, Smart, Ryan, Hayden, Doug, O’Donnell, Heather, Flint Beal, M, Cudkowicz, Merit
Format:	Artikel
Sprache:	eng
Schlagworte:	8-Hydroxy-2′-deoxyguanosine Age of Onset Amyotrophic lateral sclerosis Biomarkers - blood Biomarkers - cerebrospinal fluid Biomarkers - urine Cerebrospinal fluid Deoxyguanosine - analogs & derivatives Deoxyguanosine - blood Deoxyguanosine - cerebrospinal fluid Deoxyguanosine - urine DNA DNA Damage Female Free radicals Humans Male Middle Aged Motor Neuron Disease - cerebrospinal fluid Motor Neuron Disease - metabolism Motor Neuron Disease - urine Nervous System Diseases - cerebrospinal fluid Nervous System Diseases - metabolism Nervous System Diseases - urine Plasma Reference Values Regression Analysis Urine
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