Association of dopamine D2 receptor polymorphisms Ser311Cys and TaqIA with obesity or type 2 diabetes mellitus in Pima Indians
OBJECTIVES: To investigate whether (a) variants within the dopamine D2 receptor gene (DRD2) are associated with obesity and type 2 diabetes in Pima Indians, and (b) whether variation in this gene could be responsible for previously observed linkage to these phenotypes, at chromosome location 11q23-2...
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| creator | Jenkinson, C.P Hanson, R Cray, K Wiedrich, C Knowler, W.C Bogardus, C Baier, L |
| description | OBJECTIVES: To investigate whether (a) variants within the dopamine D2 receptor gene (DRD2) are associated with obesity and type 2 diabetes in Pima Indians, and (b) whether variation in this gene could be responsible for previously observed linkage to these phenotypes, at chromosome location 11q23-24, in this population. DESIGN: Two single nucleotide polymorphisms (SNPs), Ser311Cys and TaqIA, within the DRD2 gene were genotyped by allelic discrimination PCR in subjects who had provided evidence of linkage to diabetes and obesity in an autosome-wide scan. SUBJECTS: A total of 1187 subjects were genotyped, including 947 full heritage Pima Indians (80%). Descriptive statistics for all subjects analyzed, for whom clinical data were available, were (mean +/- s.d.): age at time of last exam = 41 +/- 15 y; birth year = 1950 +/- 14; age-sex-adjusted body mass index (BMI; adjusted to a mean age of 35 y) = 36 +/- 8 kg/m2; male = 44%; diabetic = 57%. For full heritage Pimas only: age = 43 +/- 15 y; birth year = 1948 +/- 14; sex-age-adjusted BMI = 36 +/- 8 kg/m2; male = 43%; diabetic = 59%. RESULTS: Neither polymorphism was significantly associated with diabetes in full heritage Pimas. Individuals with a 'CG' genotype at the Ser311Cys SNP had a higher BMI than those with a 'CC' genotype (36.7 vs 35.5 kg/m2, P = 0.04). Linkage analysis of BMI, adjusted for either polymorphism, resulted in LOD scores that were similar to those obtained without adjustment. CONCLUSION: Heterozygotes at the Ser311Cys DRD2 polymorphism had a slightly higher BMI than homozygotes, however neither the Ser311Cys nor the TaqIA polymorphism accounted for the linkage with BMI on chromosome 11 in Pima Indians |
| doi_str_mv | 10.1038/sj.ijo.0801381 |
| format | Article |
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DESIGN: Two single nucleotide polymorphisms (SNPs), Ser311Cys and TaqIA, within the DRD2 gene were genotyped by allelic discrimination PCR in subjects who had provided evidence of linkage to diabetes and obesity in an autosome-wide scan. SUBJECTS: A total of 1187 subjects were genotyped, including 947 full heritage Pima Indians (80%). Descriptive statistics for all subjects analyzed, for whom clinical data were available, were (mean +/- s.d.): age at time of last exam = 41 +/- 15 y; birth year = 1950 +/- 14; age-sex-adjusted body mass index (BMI; adjusted to a mean age of 35 y) = 36 +/- 8 kg/m2; male = 44%; diabetic = 57%. For full heritage Pimas only: age = 43 +/- 15 y; birth year = 1948 +/- 14; sex-age-adjusted BMI = 36 +/- 8 kg/m2; male = 43%; diabetic = 59%. RESULTS: Neither polymorphism was significantly associated with diabetes in full heritage Pimas. Individuals with a 'CG' genotype at the Ser311Cys SNP had a higher BMI than those with a 'CC' genotype (36.7 vs 35.5 kg/m2, P = 0.04). Linkage analysis of BMI, adjusted for either polymorphism, resulted in LOD scores that were similar to those obtained without adjustment. CONCLUSION: Heterozygotes at the Ser311Cys DRD2 polymorphism had a slightly higher BMI than homozygotes, however neither the Ser311Cys nor the TaqIA polymorphism accounted for the linkage with BMI on chromosome 11 in Pima Indians</description><identifier>ISSN: 0307-0565</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/sj.ijo.0801381</identifier><identifier>PMID: 11093282</identifier><language>eng</language><publisher>England: Nature Publishing Group</publisher><subject>Addictive behaviors ; Adult ; Amino acids ; Arizona ; Body Mass Index ; Chromosomes ; Diabetes ; Diabetes Mellitus, Type 2 - genetics ; Dopamine ; dopamine receptors ; Female ; genes ; Genomes ; Genotype ; Genotype & phenotype ; genotyping ; heterozygosity ; homozygosity ; Humans ; Indians, North American - genetics ; Longitudinal Studies ; Male ; males ; Middle Aged ; noninsulin-dependent diabetes mellitus ; Obesity ; Obesity - genetics ; Phenotype ; Polymerase Chain Reaction ; Polymorphism ; Polymorphism, Genetic ; Receptors, Dopamine D2 - genetics ; Signal transduction ; single nucleotide polymorphism ; statistics ; White people</subject><ispartof>International Journal of Obesity, 2000-10, Vol.24 (10), p.1233-1238</ispartof><rights>Copyright Nature Publishing Group Oct 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-27e16dab71d17b9efa2b8cf77b9105ffd2b20eb3317dc544197f29a6ab50e2e83</citedby><cites>FETCH-LOGICAL-c342t-27e16dab71d17b9efa2b8cf77b9105ffd2b20eb3317dc544197f29a6ab50e2e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11093282$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jenkinson, C.P</creatorcontrib><creatorcontrib>Hanson, R</creatorcontrib><creatorcontrib>Cray, K</creatorcontrib><creatorcontrib>Wiedrich, C</creatorcontrib><creatorcontrib>Knowler, W.C</creatorcontrib><creatorcontrib>Bogardus, C</creatorcontrib><creatorcontrib>Baier, L</creatorcontrib><title>Association of dopamine D2 receptor polymorphisms Ser311Cys and TaqIA with obesity or type 2 diabetes mellitus in Pima Indians</title><title>International Journal of Obesity</title><addtitle>Int J Obes Relat Metab Disord</addtitle><description>OBJECTIVES: To investigate whether (a) variants within the dopamine D2 receptor gene (DRD2) are associated with obesity and type 2 diabetes in Pima Indians, and (b) whether variation in this gene could be responsible for previously observed linkage to these phenotypes, at chromosome location 11q23-24, in this population. DESIGN: Two single nucleotide polymorphisms (SNPs), Ser311Cys and TaqIA, within the DRD2 gene were genotyped by allelic discrimination PCR in subjects who had provided evidence of linkage to diabetes and obesity in an autosome-wide scan. SUBJECTS: A total of 1187 subjects were genotyped, including 947 full heritage Pima Indians (80%). Descriptive statistics for all subjects analyzed, for whom clinical data were available, were (mean +/- s.d.): age at time of last exam = 41 +/- 15 y; birth year = 1950 +/- 14; age-sex-adjusted body mass index (BMI; adjusted to a mean age of 35 y) = 36 +/- 8 kg/m2; male = 44%; diabetic = 57%. For full heritage Pimas only: age = 43 +/- 15 y; birth year = 1948 +/- 14; sex-age-adjusted BMI = 36 +/- 8 kg/m2; male = 43%; diabetic = 59%. RESULTS: Neither polymorphism was significantly associated with diabetes in full heritage Pimas. Individuals with a 'CG' genotype at the Ser311Cys SNP had a higher BMI than those with a 'CC' genotype (36.7 vs 35.5 kg/m2, P = 0.04). Linkage analysis of BMI, adjusted for either polymorphism, resulted in LOD scores that were similar to those obtained without adjustment. CONCLUSION: Heterozygotes at the Ser311Cys DRD2 polymorphism had a slightly higher BMI than homozygotes, however neither the Ser311Cys nor the TaqIA polymorphism accounted for the linkage with BMI on chromosome 11 in Pima Indians</description><subject>Addictive behaviors</subject><subject>Adult</subject><subject>Amino acids</subject><subject>Arizona</subject><subject>Body Mass Index</subject><subject>Chromosomes</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Dopamine</subject><subject>dopamine receptors</subject><subject>Female</subject><subject>genes</subject><subject>Genomes</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>genotyping</subject><subject>heterozygosity</subject><subject>homozygosity</subject><subject>Humans</subject><subject>Indians, North American - genetics</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>males</subject><subject>Middle Aged</subject><subject>noninsulin-dependent diabetes mellitus</subject><subject>Obesity</subject><subject>Obesity - genetics</subject><subject>Phenotype</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic</subject><subject>Receptors, Dopamine D2 - genetics</subject><subject>Signal transduction</subject><subject>single nucleotide polymorphism</subject><subject>statistics</subject><subject>White people</subject><issn>0307-0565</issn><issn>1476-5497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkU1r3DAQhkVpabZprz22oofevNFIlmUfl00_FgIJJDkL2R43MmvL0dgUX_rbo7ILhZ5mYJ53mOFh7COILQhVXlG_9X3YilKAKuEV20BuikznlXnNNkIJkwld6Av2jqgXQmgt5Ft2ASAqJUu5YX92RKHxbvZh5KHjbZjc4Efk15JHbHCaQ-RTOK5DiNOTp4H4PUYFsF-Ju7HlD-75sOO__fzEQ43k55WnxLxOyCVvvatxRuIDHo9-Xoj7kd_5wfHDmGYjvWdvOnck_HCul-zx-7eH_c_s5vbHYb-7yRqVyzmTBqFoXW2gBVNX2DlZl01nUg9Cd10raymwVgpM2-g8h8p0snKFq7VAiaW6ZF9Pe6cYnhek2Q6emnSUGzEsZMGYUpqiSuCX_8A-LHFMt1kJlVRGaZWg7QlqYiCK2NkppqfiakHYv1os9TZpsWctKfDpvHWpB2z_4WcPCfh8AjoXrPsVPdnHeymgSM6MlqDVC1yxkvE</recordid><startdate>20001001</startdate><enddate>20001001</enddate><creator>Jenkinson, C.P</creator><creator>Hanson, R</creator><creator>Cray, K</creator><creator>Wiedrich, C</creator><creator>Knowler, W.C</creator><creator>Bogardus, C</creator><creator>Baier, L</creator><general>Nature Publishing Group</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7TK</scope><scope>7TS</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>20001001</creationdate><title>Association of dopamine D2 receptor polymorphisms Ser311Cys and TaqIA with obesity or type 2 diabetes mellitus in Pima Indians</title><author>Jenkinson, C.P ; Hanson, R ; Cray, K ; Wiedrich, C ; Knowler, W.C ; Bogardus, C ; Baier, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-27e16dab71d17b9efa2b8cf77b9105ffd2b20eb3317dc544197f29a6ab50e2e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Addictive behaviors</topic><topic>Adult</topic><topic>Amino acids</topic><topic>Arizona</topic><topic>Body Mass Index</topic><topic>Chromosomes</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - 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DESIGN: Two single nucleotide polymorphisms (SNPs), Ser311Cys and TaqIA, within the DRD2 gene were genotyped by allelic discrimination PCR in subjects who had provided evidence of linkage to diabetes and obesity in an autosome-wide scan. SUBJECTS: A total of 1187 subjects were genotyped, including 947 full heritage Pima Indians (80%). Descriptive statistics for all subjects analyzed, for whom clinical data were available, were (mean +/- s.d.): age at time of last exam = 41 +/- 15 y; birth year = 1950 +/- 14; age-sex-adjusted body mass index (BMI; adjusted to a mean age of 35 y) = 36 +/- 8 kg/m2; male = 44%; diabetic = 57%. For full heritage Pimas only: age = 43 +/- 15 y; birth year = 1948 +/- 14; sex-age-adjusted BMI = 36 +/- 8 kg/m2; male = 43%; diabetic = 59%. RESULTS: Neither polymorphism was significantly associated with diabetes in full heritage Pimas. Individuals with a 'CG' genotype at the Ser311Cys SNP had a higher BMI than those with a 'CC' genotype (36.7 vs 35.5 kg/m2, P = 0.04). Linkage analysis of BMI, adjusted for either polymorphism, resulted in LOD scores that were similar to those obtained without adjustment. CONCLUSION: Heterozygotes at the Ser311Cys DRD2 polymorphism had a slightly higher BMI than homozygotes, however neither the Ser311Cys nor the TaqIA polymorphism accounted for the linkage with BMI on chromosome 11 in Pima Indians</abstract><cop>England</cop><pub>Nature Publishing Group</pub><pmid>11093282</pmid><doi>10.1038/sj.ijo.0801381</doi><tpages>6</tpages></addata></record> |
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| subjects | Addictive behaviors Adult Amino acids Arizona Body Mass Index Chromosomes Diabetes Diabetes Mellitus, Type 2 - genetics Dopamine dopamine receptors Female genes Genomes Genotype Genotype & phenotype genotyping heterozygosity homozygosity Humans Indians, North American - genetics Longitudinal Studies Male males Middle Aged noninsulin-dependent diabetes mellitus Obesity Obesity - genetics Phenotype Polymerase Chain Reaction Polymorphism Polymorphism, Genetic Receptors, Dopamine D2 - genetics Signal transduction single nucleotide polymorphism statistics White people |
| title | Association of dopamine D2 receptor polymorphisms Ser311Cys and TaqIA with obesity or type 2 diabetes mellitus in Pima Indians |
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