Cdc123 and checkpoint forkhead associated with RING proteins control the cell cycle by controlling eIF2gamma abundance

Eukaryotic initiation factor 2 (eIF2) is a central regulator of translational initiation in times of growth and times of stress. Here we discovered three new conserved regulators of eIF2 in Saccharomyces cerevisiae. cdc123, homolog of mammalian D123, is a new cell division cycle mutant with a G2 del...

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Veröffentlicht in:	The Journal of biological chemistry 2004-10, Vol.279 (43), p.44656-44666
Hauptverfasser:	Bieganowski, Pawel, Shilinski, Kara, Tsichlis, Philip N, Brenner, Charles
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Amino Acid Sequence Base Sequence beta-Galactosidase - metabolism Binding Sites Blotting, Western Cell Cycle Cell Cycle Proteins - genetics Cell Cycle Proteins - physiology Cell Proliferation Eukaryotic Initiation Factor-2 - biosynthesis Eukaryotic Initiation Factor-2 - genetics Flow Cytometry G1 Phase G2 Phase Gene Deletion Gene Expression Regulation Heterozygote Humans Immunoprecipitation Models, Biological Molecular Sequence Data Mutagenesis, Site-Directed Mutation Open Reading Frames Phenotype Plasmids - metabolism Protein Biosynthesis Protein Structure, Tertiary Saccharomyces cerevisiae Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - biosynthesis Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - physiology Sequence Homology, Amino Acid Temperature Threonine - chemistry Time Factors Two-Hybrid System Techniques
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