Determining sequences and post-translational modifications of novel conotoxins in Conus victoriae using cDNA sequencing and mass spectrometry

A combination of cDNA cloning and detailed mass spectrometric analyses was employed to identify novel conotoxins from Conus victoriae. Eleven conotoxin sequences were determined using molecular methods: one belonging to the A superfamily (Vc1.1), six belonging to the O superfamily (Vc6.1–Vc6.6) and...

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Veröffentlicht in:	Journal of mass spectrometry. 2004-05, Vol.39 (5), p.548-557
Hauptverfasser:	Jakubowski, Jennifer A., Keays, David A., Kelley, Wayne P., Sandall, David W., Bingham, Jon-Paul, Livett, Bruce G., Gayler, Ken R., Sweedler, Jonathan V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Aminoacids, peptides. Hormones. Neuropeptides Analytical, structural and metabolic biochemistry Animal poisons toxicology. Antivenoms Animals Base Sequence Biological and medical sciences cDNA sequencing Cloning, Molecular conotoxin Conotoxins - chemistry Conotoxins - genetics Conotoxins - metabolism Conus victoriae DNA, Complementary - genetics electrospray ionization mass spectrometry Fundamental and applied biological sciences. Psychology Mass Spectrometry matrix-assisted laser desorption/ionization mass spectrometry Medical sciences Molecular Sequence Data Mollusk Venoms - chemistry Mollusk Venoms - genetics post-translational modification Protein Processing, Post-Translational Proteins Sequence Analysis, DNA Sequence Homology, Amino Acid Toxicology
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