Adiponectin acts in the brain to decrease body weight

Adiponectin (ADP) is an adipocyte hormone involved in glucose and lipid metabolism. We detected a rise in ADP in cerebrospinal fluid after intravenous (i.v.) injection, consistent with brain transport. In contrast to leptin, intracerebroventricular (i.c.v.) administration of ADP decreased body weigh...

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Veröffentlicht in:	Nature medicine 2004-05, Vol.10 (5), p.524-529
Hauptverfasser:	Qi, Yong, Takahashi, Nobuhiko, Hileman, Stanley M, Patel, Hiralben R, Berg, Anders H, Pajvani, Utpal B, Scherer, Philipp E, Ahima, Rexford S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adiponectin Agouti Signaling Protein Animals Biomedical and Life Sciences Biomedicine Body weight Body Weight - drug effects Body Weight - physiology Brain - physiology Cancer Research Drug Synergism Energy Metabolism - drug effects Hormones Infectious Diseases Injection Injections, Intraventricular Intercellular Signaling Peptides and Proteins - genetics Leptin - administration & dosage Metabolic Diseases Mice Mice, Inbred C57BL Mice, Mutant Strains Mice, Obese Molecular Medicine Neurosciences Proteins - administration & dosage Proteins - physiology Recombinant Proteins - administration & dosage
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