Sandwich-like mesoporous silica flakes for anticancer drug transport—Synthesis, characterization and kinetics release study
[Display omitted] •Synthesis and characterization of mesoporous silica nanoflakes.•Kinetics study of drug release.•Correlation between temperature and drug release.•Correlation between diffusion processes and matrix erosion mechanism. In this paper, we present the technology of synthesis, characteri...
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| Veröffentlicht in: | Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2015-12, Vol.136, p.119-125 |
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| container_title | Colloids and surfaces, B, Biointerfaces |
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| creator | Mijowska, E. Cendrowski, K. Barylak, M. Konicki, W. |
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•Synthesis and characterization of mesoporous silica nanoflakes.•Kinetics study of drug release.•Correlation between temperature and drug release.•Correlation between diffusion processes and matrix erosion mechanism.
In this paper, we present the technology of synthesis, characterization and release kinetics of anticancer drug molecules from sandwich-like mesoporous silica nanoflakes. Mesoporous silica nanoflakes are a very attractive material due to their versatility, low cytotoxicity, large surface area, high pore volume and unique feature of containing parallel pores openon both sides. Nanosilica flakes were prepared through the formation of a mesoporous silica layer on a graphene oxide surface. After graphene oxide removal, the silica nanostructures were filled by an anticancer drug—methotrexate. Release kinetics studies were performed in different temperatures, imitating the conditions in living organisms. Release data was analyzed using the zero-order model, first-order model, Higuchi model and Korsmeyer-Peppas model. The optical properties of samples, and the kinetics of drug release from the nanostructure, were examined by UV–vis spectrophotometer. Data obtained from long term studies showed that the system can serve as an anticancer drug carrier system, since a significant amount of methotrexate was loaded to the material and released. The mechanism of MTX release from mesoporous silica nanoflakes appeared to be a parallel processes of diffusion through water-filled mesopores and degradation of the mSiO2 matrix. Physical and chemical characterization was undertaken by transmission electron microscopy (TEM) and X-ray dispersion spectroscopy (EDX). The specific surface area of the samples was measured through the adsorption of N2 isotherm, interpreted with the Brunauer–Emmett–Teller model (BET). TGA and UV–vis analyses were conducted in order to estimate the amount of the released drug. |
| doi_str_mv | 10.1016/j.colsurfb.2015.09.007 |
| format | Article |
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•Synthesis and characterization of mesoporous silica nanoflakes.•Kinetics study of drug release.•Correlation between temperature and drug release.•Correlation between diffusion processes and matrix erosion mechanism.
In this paper, we present the technology of synthesis, characterization and release kinetics of anticancer drug molecules from sandwich-like mesoporous silica nanoflakes. Mesoporous silica nanoflakes are a very attractive material due to their versatility, low cytotoxicity, large surface area, high pore volume and unique feature of containing parallel pores openon both sides. Nanosilica flakes were prepared through the formation of a mesoporous silica layer on a graphene oxide surface. After graphene oxide removal, the silica nanostructures were filled by an anticancer drug—methotrexate. Release kinetics studies were performed in different temperatures, imitating the conditions in living organisms. Release data was analyzed using the zero-order model, first-order model, Higuchi model and Korsmeyer-Peppas model. The optical properties of samples, and the kinetics of drug release from the nanostructure, were examined by UV–vis spectrophotometer. Data obtained from long term studies showed that the system can serve as an anticancer drug carrier system, since a significant amount of methotrexate was loaded to the material and released. The mechanism of MTX release from mesoporous silica nanoflakes appeared to be a parallel processes of diffusion through water-filled mesopores and degradation of the mSiO2 matrix. Physical and chemical characterization was undertaken by transmission electron microscopy (TEM) and X-ray dispersion spectroscopy (EDX). The specific surface area of the samples was measured through the adsorption of N2 isotherm, interpreted with the Brunauer–Emmett–Teller model (BET). TGA and UV–vis analyses were conducted in order to estimate the amount of the released drug.</description><identifier>ISSN: 0927-7765</identifier><identifier>EISSN: 1873-4367</identifier><identifier>DOI: 10.1016/j.colsurfb.2015.09.007</identifier><identifier>PMID: 26381695</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Anticancer ; Antineoplastic Agents - administration & dosage ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacokinetics ; Drug Carriers ; Drug delivery ; Drugs ; Flakes ; Graphene ; Mesoporous silica ; Methotrexate - administration & dosage ; Methotrexate - chemistry ; Methotrexate - pharmacokinetics ; Microscopy, Electron, Transmission ; Models, Theoretical ; Nanostructure ; Oxides ; Porosity ; Release kinetics study ; Silica flakes ; Silicon dioxide ; Silicon Dioxide - chemistry ; Specific surface ; Thermodynamics</subject><ispartof>Colloids and surfaces, B, Biointerfaces, 2015-12, Vol.136, p.119-125</ispartof><rights>2015 Elsevier B.V.</rights><rights>Copyright © 2015 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-129544f73d63b18edca331f808cf8dd345df7cae6da4c67f7aa31795a4c992d83</citedby><cites>FETCH-LOGICAL-c434t-129544f73d63b18edca331f808cf8dd345df7cae6da4c67f7aa31795a4c992d83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.colsurfb.2015.09.007$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26381695$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mijowska, E.</creatorcontrib><creatorcontrib>Cendrowski, K.</creatorcontrib><creatorcontrib>Barylak, M.</creatorcontrib><creatorcontrib>Konicki, W.</creatorcontrib><title>Sandwich-like mesoporous silica flakes for anticancer drug transport—Synthesis, characterization and kinetics release study</title><title>Colloids and surfaces, B, Biointerfaces</title><addtitle>Colloids Surf B Biointerfaces</addtitle><description>[Display omitted]
•Synthesis and characterization of mesoporous silica nanoflakes.•Kinetics study of drug release.•Correlation between temperature and drug release.•Correlation between diffusion processes and matrix erosion mechanism.
In this paper, we present the technology of synthesis, characterization and release kinetics of anticancer drug molecules from sandwich-like mesoporous silica nanoflakes. Mesoporous silica nanoflakes are a very attractive material due to their versatility, low cytotoxicity, large surface area, high pore volume and unique feature of containing parallel pores openon both sides. Nanosilica flakes were prepared through the formation of a mesoporous silica layer on a graphene oxide surface. After graphene oxide removal, the silica nanostructures were filled by an anticancer drug—methotrexate. Release kinetics studies were performed in different temperatures, imitating the conditions in living organisms. Release data was analyzed using the zero-order model, first-order model, Higuchi model and Korsmeyer-Peppas model. The optical properties of samples, and the kinetics of drug release from the nanostructure, were examined by UV–vis spectrophotometer. Data obtained from long term studies showed that the system can serve as an anticancer drug carrier system, since a significant amount of methotrexate was loaded to the material and released. The mechanism of MTX release from mesoporous silica nanoflakes appeared to be a parallel processes of diffusion through water-filled mesopores and degradation of the mSiO2 matrix. Physical and chemical characterization was undertaken by transmission electron microscopy (TEM) and X-ray dispersion spectroscopy (EDX). The specific surface area of the samples was measured through the adsorption of N2 isotherm, interpreted with the Brunauer–Emmett–Teller model (BET). TGA and UV–vis analyses were conducted in order to estimate the amount of the released drug.</description><subject>Anticancer</subject><subject>Antineoplastic Agents - administration & dosage</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacokinetics</subject><subject>Drug Carriers</subject><subject>Drug delivery</subject><subject>Drugs</subject><subject>Flakes</subject><subject>Graphene</subject><subject>Mesoporous silica</subject><subject>Methotrexate - administration & dosage</subject><subject>Methotrexate - chemistry</subject><subject>Methotrexate - pharmacokinetics</subject><subject>Microscopy, Electron, Transmission</subject><subject>Models, Theoretical</subject><subject>Nanostructure</subject><subject>Oxides</subject><subject>Porosity</subject><subject>Release kinetics study</subject><subject>Silica flakes</subject><subject>Silicon dioxide</subject><subject>Silicon Dioxide - chemistry</subject><subject>Specific surface</subject><subject>Thermodynamics</subject><issn>0927-7765</issn><issn>1873-4367</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc2KFDEQx4Mo7rj6CkuOHuw26XQ--qYsfsGCh9VzyCQVJzM93WMqrYwg-BA-oU9iltn16kIgpPj9U1T9CLngrOWMq5fb1s8jLjmu245x2bKhZUw_ICtutGh6ofRDsmJDpxutlTwjTxC3jLGu5_oxOeuUMFwNckV-XrspfE9-04xpB3QPOB_mPC9IMY3JOxpHtwOkcc7UTaVWJg-Zhrx8oSW7CStd_vz6fX2cygYw4QvqNy47XyCnH66keaq5QHdpgppGmmEEh0CxLOH4lDyKbkR4dnufk89v33y6fN9cfXz34fL1VeN70ZeGd4Ps-6hFUGLNDQTvhODRMOOjCUH0MkTtHajgeq901M4JrgdZX8PQBSPOyfPTv4c8f10Ai90n9DCOboI6q-VaGyalkvdBpen6evR90E4aWUeoqDqhPs-IGaI95LR3-Wg5szdC7dbeCbU3Qi0bbBVagxe3PZb1HsK_2J3BCrw6AVD39y1BtugTVEkhZfDFhjn9r8dfev65OQ</recordid><startdate>20151201</startdate><enddate>20151201</enddate><creator>Mijowska, E.</creator><creator>Cendrowski, K.</creator><creator>Barylak, M.</creator><creator>Konicki, W.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20151201</creationdate><title>Sandwich-like mesoporous silica flakes for anticancer drug transport—Synthesis, characterization and kinetics release study</title><author>Mijowska, E. ; Cendrowski, K. ; Barylak, M. ; Konicki, W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-129544f73d63b18edca331f808cf8dd345df7cae6da4c67f7aa31795a4c992d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Anticancer</topic><topic>Antineoplastic Agents - administration & dosage</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - pharmacokinetics</topic><topic>Drug Carriers</topic><topic>Drug delivery</topic><topic>Drugs</topic><topic>Flakes</topic><topic>Graphene</topic><topic>Mesoporous silica</topic><topic>Methotrexate - administration & dosage</topic><topic>Methotrexate - chemistry</topic><topic>Methotrexate - pharmacokinetics</topic><topic>Microscopy, Electron, Transmission</topic><topic>Models, Theoretical</topic><topic>Nanostructure</topic><topic>Oxides</topic><topic>Porosity</topic><topic>Release kinetics study</topic><topic>Silica flakes</topic><topic>Silicon dioxide</topic><topic>Silicon Dioxide - chemistry</topic><topic>Specific surface</topic><topic>Thermodynamics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mijowska, E.</creatorcontrib><creatorcontrib>Cendrowski, K.</creatorcontrib><creatorcontrib>Barylak, M.</creatorcontrib><creatorcontrib>Konicki, W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Colloids and surfaces, B, Biointerfaces</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mijowska, E.</au><au>Cendrowski, K.</au><au>Barylak, M.</au><au>Konicki, W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sandwich-like mesoporous silica flakes for anticancer drug transport—Synthesis, characterization and kinetics release study</atitle><jtitle>Colloids and surfaces, B, Biointerfaces</jtitle><addtitle>Colloids Surf B Biointerfaces</addtitle><date>2015-12-01</date><risdate>2015</risdate><volume>136</volume><spage>119</spage><epage>125</epage><pages>119-125</pages><issn>0927-7765</issn><eissn>1873-4367</eissn><abstract>[Display omitted]
•Synthesis and characterization of mesoporous silica nanoflakes.•Kinetics study of drug release.•Correlation between temperature and drug release.•Correlation between diffusion processes and matrix erosion mechanism.
In this paper, we present the technology of synthesis, characterization and release kinetics of anticancer drug molecules from sandwich-like mesoporous silica nanoflakes. Mesoporous silica nanoflakes are a very attractive material due to their versatility, low cytotoxicity, large surface area, high pore volume and unique feature of containing parallel pores openon both sides. Nanosilica flakes were prepared through the formation of a mesoporous silica layer on a graphene oxide surface. After graphene oxide removal, the silica nanostructures were filled by an anticancer drug—methotrexate. Release kinetics studies were performed in different temperatures, imitating the conditions in living organisms. Release data was analyzed using the zero-order model, first-order model, Higuchi model and Korsmeyer-Peppas model. The optical properties of samples, and the kinetics of drug release from the nanostructure, were examined by UV–vis spectrophotometer. Data obtained from long term studies showed that the system can serve as an anticancer drug carrier system, since a significant amount of methotrexate was loaded to the material and released. The mechanism of MTX release from mesoporous silica nanoflakes appeared to be a parallel processes of diffusion through water-filled mesopores and degradation of the mSiO2 matrix. Physical and chemical characterization was undertaken by transmission electron microscopy (TEM) and X-ray dispersion spectroscopy (EDX). The specific surface area of the samples was measured through the adsorption of N2 isotherm, interpreted with the Brunauer–Emmett–Teller model (BET). TGA and UV–vis analyses were conducted in order to estimate the amount of the released drug.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>26381695</pmid><doi>10.1016/j.colsurfb.2015.09.007</doi><tpages>7</tpages></addata></record> |
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| subjects | Anticancer Antineoplastic Agents - administration & dosage Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacokinetics Drug Carriers Drug delivery Drugs Flakes Graphene Mesoporous silica Methotrexate - administration & dosage Methotrexate - chemistry Methotrexate - pharmacokinetics Microscopy, Electron, Transmission Models, Theoretical Nanostructure Oxides Porosity Release kinetics study Silica flakes Silicon dioxide Silicon Dioxide - chemistry Specific surface Thermodynamics |
| title | Sandwich-like mesoporous silica flakes for anticancer drug transport—Synthesis, characterization and kinetics release study |
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