Expression of aryl hydrocarbon receptor 1 (AHR1), AHR1 nuclear translocator 1 (ARNT1) and CYP1 family monooxygenase mRNAs and their activity in chicken ovarian follicles following in vitro exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
•Chicken ovarian follicles express AHR1, ARNT1 and CYP1-family monooxygenases.•TCDD and LH affect AHR1, ARNT1, CYP1A4, A5 and B1 expression in chicken ovary.•TCDD induces EROD and MROD activities both in white and yellow follicles.•The avian ovary is an organ of dioxin and dioxin-like compounds deto...
Gespeichert in:
| Veröffentlicht in: | Toxicology letters 2015-09, Vol.237 (2), p.100-111 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 111 |
|---|---|
| container_issue | 2 |
| container_start_page | 100 |
| container_title | Toxicology letters |
| container_volume | 237 |
| creator | Antos, Piotr A. Błachuta, Małgorzata Hrabia, Anna Grzegorzewska, Agnieszka K. Sechman, Andrzej |
| description | •Chicken ovarian follicles express AHR1, ARNT1 and CYP1-family monooxygenases.•TCDD and LH affect AHR1, ARNT1, CYP1A4, A5 and B1 expression in chicken ovary.•TCDD induces EROD and MROD activities both in white and yellow follicles.•The avian ovary is an organ of dioxin and dioxin-like compounds detoxification.
The aim of this in vitro study was to determine the effect of TCDD and luteinizing hormone (LH) on mRNA expression of aryl hydrocarbon receptor 1 (AHR1), AHR1 nuclear translocator 1 (ARNT1), and the CYP1 family monooxygenases (CYP1A4, CYP1A5, CYP1B1), and to assess the basal and TCDD-induced activity of these enzymes in chicken ovarian follicles. White (WF) and yellowish (YF) prehierarchical follicles and fragments of the theca (TL) and granulosa (GL) layers of the 3 largest preovulatory follicles (F3–F1) were exposed to TCDD (10nM), ovine LH (oLH; 10ng/mL) or a combination of TCDD (10nM) and oLH (10ng/mL), and increasing doses of TCDD (0.01–100nM). AHR1 and ARNT1 mRNA transcripts were found in all examined follicles. The effect of TCDD and oLH on AHR1 and ARNT1 mRNA expression depended on the maturational state of the follicle. CYP1A4 was predominantly expressed in the GL of the F3-F1 follicles; in comparison with the WF, a higher level of CYP1A5 mRNA was found both in the GL and TL of F3-F1 follicles. Alternatively, the highest level of CYP1B1 mRNA was noticed in the WF follicles. In different developmental stages of the follicle TCDD and oLH induced a different CYP1 isoform. TCDD increased EROD and MROD activities in all the investigated ovarian follicles. In conclusion, AHR1 and ARNT1 mRNA expression indicate that the chicken ovary is a target tissue for dioxin and dioxin-like compounds. The expression of CYP1-family genes and TCDD-inducible EROD and MROD activities in ovarian follicles suggest the possibility of xenobiotic detoxification in the chicken ovary. |
| doi_str_mv | 10.1016/j.toxlet.2015.05.020 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1778051089</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S037842741500209X</els_id><sourcerecordid>1746893533</sourcerecordid><originalsourceid>FETCH-LOGICAL-c428t-ccb697566aa322fd32b6cdd4f061d575e9627305a30935de27b25d2f681e90aa3</originalsourceid><addsrcrecordid>eNqNktFu0zAUhiMEYmXwBgj5spWaYjuJk9wgVd3GkKaBqnLBleXYJ6tLYme2W9q9Ni-Au25cIqQjHevo-_0f2X-SvCd4RjBhHzezYPcdhBnFpJjhWBS_SEakKus0I6x-mYxwVlZpTsv8LHnj_QZjzHJWvE7OKMN5xspilPy-3A8OvNfWINsi4Q4dWh-Us1K4Js4cSBiCdYig8fx6SSZTdGzIbGUHwqHghPFdpJ-Z5e2KTJAwCi1-fCOoFb3uDqi3xtr94Q6M8ID65e3cPzJhDdohIYPe6XBA2iC51vInxGV2wmlhUGu7Tkcv_3iyv7S5O2IRdxbBfrB-6wAFi-g0m5bTKg0Qd5LrzjqrdAPmwaZDqrTdR9V4tbi4mLxNXrWi8_DuqZ8n368uV4vr9Obr5y-L-U0qc1qFVMqG1WXBmBAZpa3KaMOkUnmLGVFFWUDNaJnhQmS4zgoFtGxooWjLKgI1jqLzZHy6d3D2fgs-8F57CV0nDNit56QsK1wQXNX_geYsYkWWRTQ_odJZ7x20fHC6jx_HCebHZPANPyWDH5PBcSyKo-zDk8O26UH9FT1HIQKfTgDEJ9lpcNxLDUaC0jEEgSur_-3wBy3RzU8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1746893533</pqid></control><display><type>article</type><title>Expression of aryl hydrocarbon receptor 1 (AHR1), AHR1 nuclear translocator 1 (ARNT1) and CYP1 family monooxygenase mRNAs and their activity in chicken ovarian follicles following in vitro exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Antos, Piotr A. ; Błachuta, Małgorzata ; Hrabia, Anna ; Grzegorzewska, Agnieszka K. ; Sechman, Andrzej</creator><creatorcontrib>Antos, Piotr A. ; Błachuta, Małgorzata ; Hrabia, Anna ; Grzegorzewska, Agnieszka K. ; Sechman, Andrzej</creatorcontrib><description>•Chicken ovarian follicles express AHR1, ARNT1 and CYP1-family monooxygenases.•TCDD and LH affect AHR1, ARNT1, CYP1A4, A5 and B1 expression in chicken ovary.•TCDD induces EROD and MROD activities both in white and yellow follicles.•The avian ovary is an organ of dioxin and dioxin-like compounds detoxification.
The aim of this in vitro study was to determine the effect of TCDD and luteinizing hormone (LH) on mRNA expression of aryl hydrocarbon receptor 1 (AHR1), AHR1 nuclear translocator 1 (ARNT1), and the CYP1 family monooxygenases (CYP1A4, CYP1A5, CYP1B1), and to assess the basal and TCDD-induced activity of these enzymes in chicken ovarian follicles. White (WF) and yellowish (YF) prehierarchical follicles and fragments of the theca (TL) and granulosa (GL) layers of the 3 largest preovulatory follicles (F3–F1) were exposed to TCDD (10nM), ovine LH (oLH; 10ng/mL) or a combination of TCDD (10nM) and oLH (10ng/mL), and increasing doses of TCDD (0.01–100nM). AHR1 and ARNT1 mRNA transcripts were found in all examined follicles. The effect of TCDD and oLH on AHR1 and ARNT1 mRNA expression depended on the maturational state of the follicle. CYP1A4 was predominantly expressed in the GL of the F3-F1 follicles; in comparison with the WF, a higher level of CYP1A5 mRNA was found both in the GL and TL of F3-F1 follicles. Alternatively, the highest level of CYP1B1 mRNA was noticed in the WF follicles. In different developmental stages of the follicle TCDD and oLH induced a different CYP1 isoform. TCDD increased EROD and MROD activities in all the investigated ovarian follicles. In conclusion, AHR1 and ARNT1 mRNA expression indicate that the chicken ovary is a target tissue for dioxin and dioxin-like compounds. The expression of CYP1-family genes and TCDD-inducible EROD and MROD activities in ovarian follicles suggest the possibility of xenobiotic detoxification in the chicken ovary.</description><identifier>ISSN: 0378-4274</identifier><identifier>EISSN: 1879-3169</identifier><identifier>DOI: 10.1016/j.toxlet.2015.05.020</identifier><identifier>PMID: 26043675</identifier><language>eng</language><publisher>Netherlands: Elsevier Ireland Ltd</publisher><subject>AHR ; Animals ; ARNT ; Aromatic compounds ; Aryl Hydrocarbon Hydroxylases - genetics ; Aryl Hydrocarbon Receptor Nuclear Translocator - genetics ; Avian Proteins - genetics ; Chicken ovarian follicles ; Chickens ; Cytochrome P-450 CYP1A1 - metabolism ; Cytochrome P-450 Enzyme System - metabolism ; Cytochrome P450 monooxygenases ; Dioxins ; Exposure ; Female ; Gene expression ; Hydrocarbons ; Ovarian Follicle - metabolism ; Ovaries ; Polychlorinated Dibenzodioxins - toxicity ; Receptors ; Receptors, Aryl Hydrocarbon - genetics ; RNA, Messenger - analysis ; TCDD</subject><ispartof>Toxicology letters, 2015-09, Vol.237 (2), p.100-111</ispartof><rights>2015 Elsevier Ireland Ltd</rights><rights>Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-ccb697566aa322fd32b6cdd4f061d575e9627305a30935de27b25d2f681e90aa3</citedby><cites>FETCH-LOGICAL-c428t-ccb697566aa322fd32b6cdd4f061d575e9627305a30935de27b25d2f681e90aa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.toxlet.2015.05.020$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26043675$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Antos, Piotr A.</creatorcontrib><creatorcontrib>Błachuta, Małgorzata</creatorcontrib><creatorcontrib>Hrabia, Anna</creatorcontrib><creatorcontrib>Grzegorzewska, Agnieszka K.</creatorcontrib><creatorcontrib>Sechman, Andrzej</creatorcontrib><title>Expression of aryl hydrocarbon receptor 1 (AHR1), AHR1 nuclear translocator 1 (ARNT1) and CYP1 family monooxygenase mRNAs and their activity in chicken ovarian follicles following in vitro exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)</title><title>Toxicology letters</title><addtitle>Toxicol Lett</addtitle><description>•Chicken ovarian follicles express AHR1, ARNT1 and CYP1-family monooxygenases.•TCDD and LH affect AHR1, ARNT1, CYP1A4, A5 and B1 expression in chicken ovary.•TCDD induces EROD and MROD activities both in white and yellow follicles.•The avian ovary is an organ of dioxin and dioxin-like compounds detoxification.
The aim of this in vitro study was to determine the effect of TCDD and luteinizing hormone (LH) on mRNA expression of aryl hydrocarbon receptor 1 (AHR1), AHR1 nuclear translocator 1 (ARNT1), and the CYP1 family monooxygenases (CYP1A4, CYP1A5, CYP1B1), and to assess the basal and TCDD-induced activity of these enzymes in chicken ovarian follicles. White (WF) and yellowish (YF) prehierarchical follicles and fragments of the theca (TL) and granulosa (GL) layers of the 3 largest preovulatory follicles (F3–F1) were exposed to TCDD (10nM), ovine LH (oLH; 10ng/mL) or a combination of TCDD (10nM) and oLH (10ng/mL), and increasing doses of TCDD (0.01–100nM). AHR1 and ARNT1 mRNA transcripts were found in all examined follicles. The effect of TCDD and oLH on AHR1 and ARNT1 mRNA expression depended on the maturational state of the follicle. CYP1A4 was predominantly expressed in the GL of the F3-F1 follicles; in comparison with the WF, a higher level of CYP1A5 mRNA was found both in the GL and TL of F3-F1 follicles. Alternatively, the highest level of CYP1B1 mRNA was noticed in the WF follicles. In different developmental stages of the follicle TCDD and oLH induced a different CYP1 isoform. TCDD increased EROD and MROD activities in all the investigated ovarian follicles. In conclusion, AHR1 and ARNT1 mRNA expression indicate that the chicken ovary is a target tissue for dioxin and dioxin-like compounds. The expression of CYP1-family genes and TCDD-inducible EROD and MROD activities in ovarian follicles suggest the possibility of xenobiotic detoxification in the chicken ovary.</description><subject>AHR</subject><subject>Animals</subject><subject>ARNT</subject><subject>Aromatic compounds</subject><subject>Aryl Hydrocarbon Hydroxylases - genetics</subject><subject>Aryl Hydrocarbon Receptor Nuclear Translocator - genetics</subject><subject>Avian Proteins - genetics</subject><subject>Chicken ovarian follicles</subject><subject>Chickens</subject><subject>Cytochrome P-450 CYP1A1 - metabolism</subject><subject>Cytochrome P-450 Enzyme System - metabolism</subject><subject>Cytochrome P450 monooxygenases</subject><subject>Dioxins</subject><subject>Exposure</subject><subject>Female</subject><subject>Gene expression</subject><subject>Hydrocarbons</subject><subject>Ovarian Follicle - metabolism</subject><subject>Ovaries</subject><subject>Polychlorinated Dibenzodioxins - toxicity</subject><subject>Receptors</subject><subject>Receptors, Aryl Hydrocarbon - genetics</subject><subject>RNA, Messenger - analysis</subject><subject>TCDD</subject><issn>0378-4274</issn><issn>1879-3169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNktFu0zAUhiMEYmXwBgj5spWaYjuJk9wgVd3GkKaBqnLBleXYJ6tLYme2W9q9Ni-Au25cIqQjHevo-_0f2X-SvCd4RjBhHzezYPcdhBnFpJjhWBS_SEakKus0I6x-mYxwVlZpTsv8LHnj_QZjzHJWvE7OKMN5xspilPy-3A8OvNfWINsi4Q4dWh-Us1K4Js4cSBiCdYig8fx6SSZTdGzIbGUHwqHghPFdpJ-Z5e2KTJAwCi1-fCOoFb3uDqi3xtr94Q6M8ID65e3cPzJhDdohIYPe6XBA2iC51vInxGV2wmlhUGu7Tkcv_3iyv7S5O2IRdxbBfrB-6wAFi-g0m5bTKg0Qd5LrzjqrdAPmwaZDqrTdR9V4tbi4mLxNXrWi8_DuqZ8n368uV4vr9Obr5y-L-U0qc1qFVMqG1WXBmBAZpa3KaMOkUnmLGVFFWUDNaJnhQmS4zgoFtGxooWjLKgI1jqLzZHy6d3D2fgs-8F57CV0nDNit56QsK1wQXNX_geYsYkWWRTQ_odJZ7x20fHC6jx_HCebHZPANPyWDH5PBcSyKo-zDk8O26UH9FT1HIQKfTgDEJ9lpcNxLDUaC0jEEgSur_-3wBy3RzU8</recordid><startdate>20150902</startdate><enddate>20150902</enddate><creator>Antos, Piotr A.</creator><creator>Błachuta, Małgorzata</creator><creator>Hrabia, Anna</creator><creator>Grzegorzewska, Agnieszka K.</creator><creator>Sechman, Andrzej</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>7U7</scope><scope>C1K</scope><scope>SOI</scope><scope>8FD</scope><scope>FR3</scope><scope>KR7</scope></search><sort><creationdate>20150902</creationdate><title>Expression of aryl hydrocarbon receptor 1 (AHR1), AHR1 nuclear translocator 1 (ARNT1) and CYP1 family monooxygenase mRNAs and their activity in chicken ovarian follicles following in vitro exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)</title><author>Antos, Piotr A. ; Błachuta, Małgorzata ; Hrabia, Anna ; Grzegorzewska, Agnieszka K. ; Sechman, Andrzej</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-ccb697566aa322fd32b6cdd4f061d575e9627305a30935de27b25d2f681e90aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>AHR</topic><topic>Animals</topic><topic>ARNT</topic><topic>Aromatic compounds</topic><topic>Aryl Hydrocarbon Hydroxylases - genetics</topic><topic>Aryl Hydrocarbon Receptor Nuclear Translocator - genetics</topic><topic>Avian Proteins - genetics</topic><topic>Chicken ovarian follicles</topic><topic>Chickens</topic><topic>Cytochrome P-450 CYP1A1 - metabolism</topic><topic>Cytochrome P-450 Enzyme System - metabolism</topic><topic>Cytochrome P450 monooxygenases</topic><topic>Dioxins</topic><topic>Exposure</topic><topic>Female</topic><topic>Gene expression</topic><topic>Hydrocarbons</topic><topic>Ovarian Follicle - metabolism</topic><topic>Ovaries</topic><topic>Polychlorinated Dibenzodioxins - toxicity</topic><topic>Receptors</topic><topic>Receptors, Aryl Hydrocarbon - genetics</topic><topic>RNA, Messenger - analysis</topic><topic>TCDD</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Antos, Piotr A.</creatorcontrib><creatorcontrib>Błachuta, Małgorzata</creatorcontrib><creatorcontrib>Hrabia, Anna</creatorcontrib><creatorcontrib>Grzegorzewska, Agnieszka K.</creatorcontrib><creatorcontrib>Sechman, Andrzej</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Civil Engineering Abstracts</collection><jtitle>Toxicology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Antos, Piotr A.</au><au>Błachuta, Małgorzata</au><au>Hrabia, Anna</au><au>Grzegorzewska, Agnieszka K.</au><au>Sechman, Andrzej</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of aryl hydrocarbon receptor 1 (AHR1), AHR1 nuclear translocator 1 (ARNT1) and CYP1 family monooxygenase mRNAs and their activity in chicken ovarian follicles following in vitro exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)</atitle><jtitle>Toxicology letters</jtitle><addtitle>Toxicol Lett</addtitle><date>2015-09-02</date><risdate>2015</risdate><volume>237</volume><issue>2</issue><spage>100</spage><epage>111</epage><pages>100-111</pages><issn>0378-4274</issn><eissn>1879-3169</eissn><abstract>•Chicken ovarian follicles express AHR1, ARNT1 and CYP1-family monooxygenases.•TCDD and LH affect AHR1, ARNT1, CYP1A4, A5 and B1 expression in chicken ovary.•TCDD induces EROD and MROD activities both in white and yellow follicles.•The avian ovary is an organ of dioxin and dioxin-like compounds detoxification.
The aim of this in vitro study was to determine the effect of TCDD and luteinizing hormone (LH) on mRNA expression of aryl hydrocarbon receptor 1 (AHR1), AHR1 nuclear translocator 1 (ARNT1), and the CYP1 family monooxygenases (CYP1A4, CYP1A5, CYP1B1), and to assess the basal and TCDD-induced activity of these enzymes in chicken ovarian follicles. White (WF) and yellowish (YF) prehierarchical follicles and fragments of the theca (TL) and granulosa (GL) layers of the 3 largest preovulatory follicles (F3–F1) were exposed to TCDD (10nM), ovine LH (oLH; 10ng/mL) or a combination of TCDD (10nM) and oLH (10ng/mL), and increasing doses of TCDD (0.01–100nM). AHR1 and ARNT1 mRNA transcripts were found in all examined follicles. The effect of TCDD and oLH on AHR1 and ARNT1 mRNA expression depended on the maturational state of the follicle. CYP1A4 was predominantly expressed in the GL of the F3-F1 follicles; in comparison with the WF, a higher level of CYP1A5 mRNA was found both in the GL and TL of F3-F1 follicles. Alternatively, the highest level of CYP1B1 mRNA was noticed in the WF follicles. In different developmental stages of the follicle TCDD and oLH induced a different CYP1 isoform. TCDD increased EROD and MROD activities in all the investigated ovarian follicles. In conclusion, AHR1 and ARNT1 mRNA expression indicate that the chicken ovary is a target tissue for dioxin and dioxin-like compounds. The expression of CYP1-family genes and TCDD-inducible EROD and MROD activities in ovarian follicles suggest the possibility of xenobiotic detoxification in the chicken ovary.</abstract><cop>Netherlands</cop><pub>Elsevier Ireland Ltd</pub><pmid>26043675</pmid><doi>10.1016/j.toxlet.2015.05.020</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-4274 |
| ispartof | Toxicology letters, 2015-09, Vol.237 (2), p.100-111 |
| issn | 0378-4274 1879-3169 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1778051089 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | AHR Animals ARNT Aromatic compounds Aryl Hydrocarbon Hydroxylases - genetics Aryl Hydrocarbon Receptor Nuclear Translocator - genetics Avian Proteins - genetics Chicken ovarian follicles Chickens Cytochrome P-450 CYP1A1 - metabolism Cytochrome P-450 Enzyme System - metabolism Cytochrome P450 monooxygenases Dioxins Exposure Female Gene expression Hydrocarbons Ovarian Follicle - metabolism Ovaries Polychlorinated Dibenzodioxins - toxicity Receptors Receptors, Aryl Hydrocarbon - genetics RNA, Messenger - analysis TCDD |
| title | Expression of aryl hydrocarbon receptor 1 (AHR1), AHR1 nuclear translocator 1 (ARNT1) and CYP1 family monooxygenase mRNAs and their activity in chicken ovarian follicles following in vitro exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T00%3A49%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Expression%20of%20aryl%20hydrocarbon%20receptor%201%20(AHR1),%20AHR1%20nuclear%20translocator%201%20(ARNT1)%20and%20CYP1%20family%20monooxygenase%20mRNAs%20and%20their%20activity%20in%20chicken%20ovarian%20follicles%20following%20in%20vitro%20exposure%20to%202,3,7,8-tetrachlorodibenzo-p-dioxin%20(TCDD)&rft.jtitle=Toxicology%20letters&rft.au=Antos,%20Piotr%20A.&rft.date=2015-09-02&rft.volume=237&rft.issue=2&rft.spage=100&rft.epage=111&rft.pages=100-111&rft.issn=0378-4274&rft.eissn=1879-3169&rft_id=info:doi/10.1016/j.toxlet.2015.05.020&rft_dat=%3Cproquest_cross%3E1746893533%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1746893533&rft_id=info:pmid/26043675&rft_els_id=S037842741500209X&rfr_iscdi=true |