Chitosan thermogels for local expansion and delivery of tumor-specific T lymphocytes towards enhanced cancer immunotherapies

Abstract The success of promising anti-cancer adoptive cell therapies relies on the abilities of the perfused CD8+ T lymphocytes to gain access to and persist within the tumor microenvironment to carry out their cytotoxic functions. We propose a new method for their local delivery as a living concen...

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Veröffentlicht in:	Biomaterials 2016-01, Vol.75, p.237-249
Hauptverfasser:	Monette, Anne, Ceccaldi, Caroline, Assaad, Elias, Lerouge, Sophie, Lapointe, Réjean
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Animals Cancer CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - drug effects Cell Movement - drug effects Cell Proliferation Cell Survival Chitosan Chitosan - pharmacology Complement Cytotoxicity, Immunologic - drug effects Dentistry Encapsulation Formulations Gelation Gels - pharmacology Humans Hydrogel Immunotherapy Injectable Injections Kidney Neoplasms - immunology Kidney Neoplasms - therapy Lymphocyte Activation - drug effects Lymphocytes Lymphocytes, Tumor-Infiltrating - drug effects Lymphocytes, Tumor-Infiltrating - immunology Materials Testing Phenotype Porosity Rats Rheology Sodium T lymphocytes Temperature Tumors
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