Optimizing Divalent Inhibitors of Pseudomonas aeruginosa Lectin LecA by Using A Rigid Spacer

Optimizing Divalent Inhibitors of Pseudomonas aeruginosa Lectin LecA by Using A Rigid Spacer

Rigid spacers: Optimal highly potent divalent ligands of the P. aeruginosa lectin LecA have been prepared. The ligands consist of a rigid spacer derived from glucose–triazole units (see figure). Systematic variation of the number of spacer units and the aglycon linker led to a 7500‐fold enhancement...

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Veröffentlicht in:Chemistry : a European journal 2013-12, Vol.19 (50), p.16923-16927
Hauptverfasser: Pertici, Francesca, de Mol, Nico J., Kemmink, Johan, Pieters, Roland J.
Format: Artikel
Sprache:eng
Schlagworte:
Adhesins, Bacterial - chemistry
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
carbohydrates
Carbohydrates - chemistry
Chemistry
glycoconjugates
Glycoconjugates - chemistry
Inhibitors
Lectins
Lectins - chemistry
Ligands
multivalency
Optimization
Pseudomonas aeruginosa
Pseudomonas aeruginosa - chemistry
rigid spacers
Spacers
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Zusammenfassung:Rigid spacers: Optimal highly potent divalent ligands of the P. aeruginosa lectin LecA have been prepared. The ligands consist of a rigid spacer derived from glucose–triazole units (see figure). Systematic variation of the number of spacer units and the aglycon linker led to a 7500‐fold enhancement in potency.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201303463