Structure of the BoNT/A1 – receptor complex
Botulinum neurotoxin A causes botulism but is also used for medical and cosmetic applications. A detailed molecular understanding of BoNT/A – host receptor interactions is therefore fundamental for improving current clinical applications and for developing new medical strategies targeting human diso...
Gespeichert in:
| Veröffentlicht in: | Toxicon (Oxford) 2015-12, Vol.107 (Pt A), p.25-31 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 31 |
|---|---|
| container_issue | Pt A |
| container_start_page | 25 |
| container_title | Toxicon (Oxford) |
| container_volume | 107 |
| creator | Benoit, Roger M. Frey, Daniel Wieser, Mara M. Thieltges, Katherine M. Jaussi, Rolf Capitani, Guido Kammerer, Richard A. |
| description | Botulinum neurotoxin A causes botulism but is also used for medical and cosmetic applications. A detailed molecular understanding of BoNT/A – host receptor interactions is therefore fundamental for improving current clinical applications and for developing new medical strategies targeting human disorders. Towards this end, we recently solved an X-ray crystal structure of BoNT/A1 in complex with its neuronal protein receptor SV2C. Based on our findings, we discuss the potential implications for BoNT/A function. |
| doi_str_mv | 10.1016/j.toxicon.2015.08.002 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1778037034</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0041010115300325</els_id><sourcerecordid>1751211778</sourcerecordid><originalsourceid>FETCH-LOGICAL-c501t-c1ece4bd82d731e48dd0165bdf7f30fc6a0d14a3fcc21bd9600f9304910842973</originalsourceid><addsrcrecordid>eNqNkEtOwzAQQC0EoqVwBFCWbJLO2PmuUKn4SQgWlLWV-CNSJXWwE1R23IEbchJctbCF1Wzemxk9Qk4RIgRMp8uoN-tamFVEAZMI8giA7pEx5lkRMkxgn4wBYgzB4yNy5NwSAFhepIdkRFOaQlrQMQmfejuIfrAqMDroX1RwaR4W0xkGXx-fgVVCdb2xgTBt16j1MTnQZePUyW5OyPP11WJ-G94_3tzNZ_ehSAD7UKD34krmVGYMVZxL6V9OKqkzzUCLtASJccm0EBQrWaQAumAQFwh5TIuMTcj5dm9nzeugXM_b2gnVNOVKmcFxzLIcWAYs_geaIMWN4NFkiwprnLNK887WbWnfOQLfROVLvovKN1E55NxH9d7Z7sRQtUr-Wj8VPXCxBZRv8lYry52o1UooWfuCPZem_uPEN2VZiU8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1751211778</pqid></control><display><type>article</type><title>Structure of the BoNT/A1 – receptor complex</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Benoit, Roger M. ; Frey, Daniel ; Wieser, Mara M. ; Thieltges, Katherine M. ; Jaussi, Rolf ; Capitani, Guido ; Kammerer, Richard A.</creator><creatorcontrib>Benoit, Roger M. ; Frey, Daniel ; Wieser, Mara M. ; Thieltges, Katherine M. ; Jaussi, Rolf ; Capitani, Guido ; Kammerer, Richard A.</creatorcontrib><description>Botulinum neurotoxin A causes botulism but is also used for medical and cosmetic applications. A detailed molecular understanding of BoNT/A – host receptor interactions is therefore fundamental for improving current clinical applications and for developing new medical strategies targeting human disorders. Towards this end, we recently solved an X-ray crystal structure of BoNT/A1 in complex with its neuronal protein receptor SV2C. Based on our findings, we discuss the potential implications for BoNT/A function.</description><identifier>ISSN: 0041-0101</identifier><identifier>EISSN: 1879-3150</identifier><identifier>DOI: 10.1016/j.toxicon.2015.08.002</identifier><identifier>PMID: 26260692</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; BoNT/A ; Botulinum Toxins, Type A - chemistry ; Botulinum Toxins, Type A - metabolism ; Clostridium botulinum ; Cosmetics ; Crystal structure ; Crystallography, X-Ray ; Human ; Humans ; Medical ; Membrane Glycoproteins - chemistry ; Membrane Glycoproteins - metabolism ; Molecular Structure ; Neurons - metabolism ; Protein Binding ; Receptors ; Strategy ; Subtype ; SV2C ; Toxins ; X-ray crystallography ; X-rays</subject><ispartof>Toxicon (Oxford), 2015-12, Vol.107 (Pt A), p.25-31</ispartof><rights>2015 Elsevier Ltd</rights><rights>Copyright © 2015 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c501t-c1ece4bd82d731e48dd0165bdf7f30fc6a0d14a3fcc21bd9600f9304910842973</citedby><cites>FETCH-LOGICAL-c501t-c1ece4bd82d731e48dd0165bdf7f30fc6a0d14a3fcc21bd9600f9304910842973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.toxicon.2015.08.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26260692$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Benoit, Roger M.</creatorcontrib><creatorcontrib>Frey, Daniel</creatorcontrib><creatorcontrib>Wieser, Mara M.</creatorcontrib><creatorcontrib>Thieltges, Katherine M.</creatorcontrib><creatorcontrib>Jaussi, Rolf</creatorcontrib><creatorcontrib>Capitani, Guido</creatorcontrib><creatorcontrib>Kammerer, Richard A.</creatorcontrib><title>Structure of the BoNT/A1 – receptor complex</title><title>Toxicon (Oxford)</title><addtitle>Toxicon</addtitle><description>Botulinum neurotoxin A causes botulism but is also used for medical and cosmetic applications. A detailed molecular understanding of BoNT/A – host receptor interactions is therefore fundamental for improving current clinical applications and for developing new medical strategies targeting human disorders. Towards this end, we recently solved an X-ray crystal structure of BoNT/A1 in complex with its neuronal protein receptor SV2C. Based on our findings, we discuss the potential implications for BoNT/A function.</description><subject>Animals</subject><subject>BoNT/A</subject><subject>Botulinum Toxins, Type A - chemistry</subject><subject>Botulinum Toxins, Type A - metabolism</subject><subject>Clostridium botulinum</subject><subject>Cosmetics</subject><subject>Crystal structure</subject><subject>Crystallography, X-Ray</subject><subject>Human</subject><subject>Humans</subject><subject>Medical</subject><subject>Membrane Glycoproteins - chemistry</subject><subject>Membrane Glycoproteins - metabolism</subject><subject>Molecular Structure</subject><subject>Neurons - metabolism</subject><subject>Protein Binding</subject><subject>Receptors</subject><subject>Strategy</subject><subject>Subtype</subject><subject>SV2C</subject><subject>Toxins</subject><subject>X-ray crystallography</subject><subject>X-rays</subject><issn>0041-0101</issn><issn>1879-3150</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEtOwzAQQC0EoqVwBFCWbJLO2PmuUKn4SQgWlLWV-CNSJXWwE1R23IEbchJctbCF1Wzemxk9Qk4RIgRMp8uoN-tamFVEAZMI8giA7pEx5lkRMkxgn4wBYgzB4yNy5NwSAFhepIdkRFOaQlrQMQmfejuIfrAqMDroX1RwaR4W0xkGXx-fgVVCdb2xgTBt16j1MTnQZePUyW5OyPP11WJ-G94_3tzNZ_ehSAD7UKD34krmVGYMVZxL6V9OKqkzzUCLtASJccm0EBQrWaQAumAQFwh5TIuMTcj5dm9nzeugXM_b2gnVNOVKmcFxzLIcWAYs_geaIMWN4NFkiwprnLNK887WbWnfOQLfROVLvovKN1E55NxH9d7Z7sRQtUr-Wj8VPXCxBZRv8lYry52o1UooWfuCPZem_uPEN2VZiU8</recordid><startdate>20151201</startdate><enddate>20151201</enddate><creator>Benoit, Roger M.</creator><creator>Frey, Daniel</creator><creator>Wieser, Mara M.</creator><creator>Thieltges, Katherine M.</creator><creator>Jaussi, Rolf</creator><creator>Capitani, Guido</creator><creator>Kammerer, Richard A.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>8FD</scope><scope>FR3</scope><scope>KR7</scope></search><sort><creationdate>20151201</creationdate><title>Structure of the BoNT/A1 – receptor complex</title><author>Benoit, Roger M. ; Frey, Daniel ; Wieser, Mara M. ; Thieltges, Katherine M. ; Jaussi, Rolf ; Capitani, Guido ; Kammerer, Richard A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c501t-c1ece4bd82d731e48dd0165bdf7f30fc6a0d14a3fcc21bd9600f9304910842973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>BoNT/A</topic><topic>Botulinum Toxins, Type A - chemistry</topic><topic>Botulinum Toxins, Type A - metabolism</topic><topic>Clostridium botulinum</topic><topic>Cosmetics</topic><topic>Crystal structure</topic><topic>Crystallography, X-Ray</topic><topic>Human</topic><topic>Humans</topic><topic>Medical</topic><topic>Membrane Glycoproteins - chemistry</topic><topic>Membrane Glycoproteins - metabolism</topic><topic>Molecular Structure</topic><topic>Neurons - metabolism</topic><topic>Protein Binding</topic><topic>Receptors</topic><topic>Strategy</topic><topic>Subtype</topic><topic>SV2C</topic><topic>Toxins</topic><topic>X-ray crystallography</topic><topic>X-rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Benoit, Roger M.</creatorcontrib><creatorcontrib>Frey, Daniel</creatorcontrib><creatorcontrib>Wieser, Mara M.</creatorcontrib><creatorcontrib>Thieltges, Katherine M.</creatorcontrib><creatorcontrib>Jaussi, Rolf</creatorcontrib><creatorcontrib>Capitani, Guido</creatorcontrib><creatorcontrib>Kammerer, Richard A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Civil Engineering Abstracts</collection><jtitle>Toxicon (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Benoit, Roger M.</au><au>Frey, Daniel</au><au>Wieser, Mara M.</au><au>Thieltges, Katherine M.</au><au>Jaussi, Rolf</au><au>Capitani, Guido</au><au>Kammerer, Richard A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Structure of the BoNT/A1 – receptor complex</atitle><jtitle>Toxicon (Oxford)</jtitle><addtitle>Toxicon</addtitle><date>2015-12-01</date><risdate>2015</risdate><volume>107</volume><issue>Pt A</issue><spage>25</spage><epage>31</epage><pages>25-31</pages><issn>0041-0101</issn><eissn>1879-3150</eissn><abstract>Botulinum neurotoxin A causes botulism but is also used for medical and cosmetic applications. A detailed molecular understanding of BoNT/A – host receptor interactions is therefore fundamental for improving current clinical applications and for developing new medical strategies targeting human disorders. Towards this end, we recently solved an X-ray crystal structure of BoNT/A1 in complex with its neuronal protein receptor SV2C. Based on our findings, we discuss the potential implications for BoNT/A function.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>26260692</pmid><doi>10.1016/j.toxicon.2015.08.002</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0041-0101 |
| ispartof | Toxicon (Oxford), 2015-12, Vol.107 (Pt A), p.25-31 |
| issn | 0041-0101 1879-3150 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1778037034 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals BoNT/A Botulinum Toxins, Type A - chemistry Botulinum Toxins, Type A - metabolism Clostridium botulinum Cosmetics Crystal structure Crystallography, X-Ray Human Humans Medical Membrane Glycoproteins - chemistry Membrane Glycoproteins - metabolism Molecular Structure Neurons - metabolism Protein Binding Receptors Strategy Subtype SV2C Toxins X-ray crystallography X-rays |
| title | Structure of the BoNT/A1 – receptor complex |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T02%3A14%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Structure%20of%20the%20BoNT/A1%20%E2%80%93%20receptor%20complex&rft.jtitle=Toxicon%20(Oxford)&rft.au=Benoit,%20Roger%20M.&rft.date=2015-12-01&rft.volume=107&rft.issue=Pt%20A&rft.spage=25&rft.epage=31&rft.pages=25-31&rft.issn=0041-0101&rft.eissn=1879-3150&rft_id=info:doi/10.1016/j.toxicon.2015.08.002&rft_dat=%3Cproquest_cross%3E1751211778%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1751211778&rft_id=info:pmid/26260692&rft_els_id=S0041010115300325&rfr_iscdi=true |