Linear and Cyclic Hybrids of Alternating Thiophene-Amino Acid Units: Synthesis and Effects of Chirality on Conformation and Molecular Packing

The dipeptide isostere 5‐aminothiophene carboxylic acid has been combined with L‐phenylalanine moieties to provide linear and cyclic hybrid oligopeptides. A suitable protecting group strategy and appropriate coupling methods have been developed to guarantee a high degree of enantiopurity of the resu...

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Veröffentlicht in:	Chemistry : a European journal 2013-11, Vol.19 (45), p.15155-15165
Hauptverfasser:	Ngo, Thien H., Berndt, Hülya, Wilsdorf, Michael, Lentz, Dieter, Reissig, Hans-Ulrich
Format:	Artikel
Sprache:	eng
Schlagworte:	amino acids Amino Acids - chemistry Boats Chemistry Chirality Coupling (molecular) crystal packing Crystal structure Cyclization Derivatives dipeptide isosteres Dipeptides - chemistry macrocycles Molecular Conformation peptidomimetics Phenylalanine Precursors ring conformation Strategy thiophene Thiophenes - chemistry
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