Theory of the Formation and Decomposition of N-Heterocyclic Aminooxycarbenes through Metal-Assisted [2+3]-Dipolar Cycloaddition/Retro-Cycloaddition
The theoretical background of the formation of N‐heterocyclic oxadiazoline carbenes through a metal‐assisted [2+3]‐dipolar cycloaddition (CA) reaction of nitrones R1CHN(R2)O to isocyanides CNR and the decomposition of these carbenes to imines R1CHNR2 and isocyanates OCNR is discussed. Furthermo...
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Veröffentlicht in: | Chemistry : a European journal 2013-02, Vol.19 (8), p.2874-2888 |
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description | The theoretical background of the formation of N‐heterocyclic oxadiazoline carbenes through a metal‐assisted [2+3]‐dipolar cycloaddition (CA) reaction of nitrones R1CHN(R2)O to isocyanides CNR and the decomposition of these carbenes to imines R1CHNR2 and isocyanates OCNR is discussed. Furthermore, the reaction mechanisms and factors that govern these processes are analyzed in detail. In the absence of a metal, oxadiazoline carbenes should not be accessible due to the high activation energy of their formation and their low thermodynamic stability. The most efficient promotors that could assist the synthesis of these species should be “carbenophilic” metals that form a strong bond with the oxadiazoline heterocycle, but without significant involvement of π‐back donation, namely, AuI, AuIII, PtII, PtIV, ReV, and PdII metal centers. These metals, on the one hand, significantly facilitate the coupling of nitrones with isocyanides and, on the other hand, stabilize the derived carbene heterocycles toward decomposition. The energy of the LUMOCNR and the charge on the N atom of the CN group are principal factors that control the cycloaddition of nitrones to isocyanides. The alkyl‐substituted nitrones and isocyanides are predicted to be more active in the CA reaction than the aryl‐substituted species, and the N,N,C‐alkyloxadiazolines are more stable toward decomposition relative to the aryl derivatives.
Going in circles: The theoretical background of the formation of N‐heterocyclic aminooxycarbenes through a metal‐assisted [2+3]‐cycloaddition of nitrones to isocyanides and of their decomposition to imines and isocyanates is discussed (see scheme). |
doi_str_mv | 10.1002/chem.201203098 |
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Going in circles: The theoretical background of the formation of N‐heterocyclic aminooxycarbenes through a metal‐assisted [2+3]‐cycloaddition of nitrones to isocyanides and of their decomposition to imines and isocyanates is discussed (see scheme).</description><identifier>ISSN: 0947-6539</identifier><identifier>EISSN: 1521-3765</identifier><identifier>DOI: 10.1002/chem.201203098</identifier><identifier>PMID: 23296691</identifier><identifier>CODEN: CEUJED</identifier><language>eng</language><publisher>Weinheim: WILEY-VCH Verlag</publisher><subject>Carbenes ; Chemistry ; Cycloaddition ; Decomposition ; Decomposition reactions ; density functional calculations ; Derivatives ; Formations ; Imines ; Isocyanates ; isocyanides ; N-heterocyclic carbenes ; reaction mechanisms ; Theory</subject><ispartof>Chemistry : a European journal, 2013-02, Vol.19 (8), p.2874-2888</ispartof><rights>Copyright © 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><rights>Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4448-21fc56b3f31e6272ff47aa28357a2aaf8ab4a6a9c71fe4fa25acb2de9e36e0523</citedby><cites>FETCH-LOGICAL-c4448-21fc56b3f31e6272ff47aa28357a2aaf8ab4a6a9c71fe4fa25acb2de9e36e0523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fchem.201203098$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fchem.201203098$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23296691$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Novikov, Alexander S.</creatorcontrib><creatorcontrib>Kuznetsov, Maxim L.</creatorcontrib><creatorcontrib>Pombeiro, Armando J. L.</creatorcontrib><title>Theory of the Formation and Decomposition of N-Heterocyclic Aminooxycarbenes through Metal-Assisted [2+3]-Dipolar Cycloaddition/Retro-Cycloaddition</title><title>Chemistry : a European journal</title><addtitle>Chem. Eur. J</addtitle><description>The theoretical background of the formation of N‐heterocyclic oxadiazoline carbenes through a metal‐assisted [2+3]‐dipolar cycloaddition (CA) reaction of nitrones R1CHN(R2)O to isocyanides CNR and the decomposition of these carbenes to imines R1CHNR2 and isocyanates OCNR is discussed. Furthermore, the reaction mechanisms and factors that govern these processes are analyzed in detail. In the absence of a metal, oxadiazoline carbenes should not be accessible due to the high activation energy of their formation and their low thermodynamic stability. The most efficient promotors that could assist the synthesis of these species should be “carbenophilic” metals that form a strong bond with the oxadiazoline heterocycle, but without significant involvement of π‐back donation, namely, AuI, AuIII, PtII, PtIV, ReV, and PdII metal centers. These metals, on the one hand, significantly facilitate the coupling of nitrones with isocyanides and, on the other hand, stabilize the derived carbene heterocycles toward decomposition. The energy of the LUMOCNR and the charge on the N atom of the CN group are principal factors that control the cycloaddition of nitrones to isocyanides. The alkyl‐substituted nitrones and isocyanides are predicted to be more active in the CA reaction than the aryl‐substituted species, and the N,N,C‐alkyloxadiazolines are more stable toward decomposition relative to the aryl derivatives.
Going in circles: The theoretical background of the formation of N‐heterocyclic aminooxycarbenes through a metal‐assisted [2+3]‐cycloaddition of nitrones to isocyanides and of their decomposition to imines and isocyanates is discussed (see scheme).</description><subject>Carbenes</subject><subject>Chemistry</subject><subject>Cycloaddition</subject><subject>Decomposition</subject><subject>Decomposition reactions</subject><subject>density functional calculations</subject><subject>Derivatives</subject><subject>Formations</subject><subject>Imines</subject><subject>Isocyanates</subject><subject>isocyanides</subject><subject>N-heterocyclic carbenes</subject><subject>reaction mechanisms</subject><subject>Theory</subject><issn>0947-6539</issn><issn>1521-3765</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqFkV1r1EAYRoModq3eeikBbwTJdr4nc7ndfqylrSCVSkWG2ck7btoks84ktPkd_cMm3bqoN70aeDnPgeEkyVuMphghsmdXUE8JwgRRpPJnyQRzgjMqBX-eTJBiMhOcqp3kVYzXCCElKH2Z7BBKlBAKT5L7ixX40Kfepe0K0iMfatOWvklNU6QHYH299rF8uAzIebaAFoK3va1Km87qsvH-rrcmLKGBOCiC736u0jNoTZXNYixjC0X6nXykP7KDcu0rE9L5MPamKB6se1-gDT775_Y6eeFMFeHN47ubfD06vJgvstPPx5_ms9PMMsbyjGBnuVhSRzEIIolzTBpDcsqlIca43CyZEUZZiR0wZwg3dkkKUEAFIE7obvJh410H_6uD2Oq6jBaqyjTgu6ixlDmihFH6NEpySXPF-Yi-_w-99l1oho-MFGcMYcYGarqhbPAxBnB6HcrahF5jpMeyeiyrt2WHwbtHbbesodjif1IOgNoAt2UF_RM6PV8cnv0tzzbbsdfddmvCjRaSSq4vz4_1_snV1bf9k0ut6G9LAcEK</recordid><startdate>20130218</startdate><enddate>20130218</enddate><creator>Novikov, Alexander S.</creator><creator>Kuznetsov, Maxim L.</creator><creator>Pombeiro, Armando J. L.</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20130218</creationdate><title>Theory of the Formation and Decomposition of N-Heterocyclic Aminooxycarbenes through Metal-Assisted [2+3]-Dipolar Cycloaddition/Retro-Cycloaddition</title><author>Novikov, Alexander S. ; Kuznetsov, Maxim L. ; Pombeiro, Armando J. L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4448-21fc56b3f31e6272ff47aa28357a2aaf8ab4a6a9c71fe4fa25acb2de9e36e0523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Carbenes</topic><topic>Chemistry</topic><topic>Cycloaddition</topic><topic>Decomposition</topic><topic>Decomposition reactions</topic><topic>density functional calculations</topic><topic>Derivatives</topic><topic>Formations</topic><topic>Imines</topic><topic>Isocyanates</topic><topic>isocyanides</topic><topic>N-heterocyclic carbenes</topic><topic>reaction mechanisms</topic><topic>Theory</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Novikov, Alexander S.</creatorcontrib><creatorcontrib>Kuznetsov, Maxim L.</creatorcontrib><creatorcontrib>Pombeiro, Armando J. L.</creatorcontrib><collection>Istex</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Chemistry : a European journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Novikov, Alexander S.</au><au>Kuznetsov, Maxim L.</au><au>Pombeiro, Armando J. L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Theory of the Formation and Decomposition of N-Heterocyclic Aminooxycarbenes through Metal-Assisted [2+3]-Dipolar Cycloaddition/Retro-Cycloaddition</atitle><jtitle>Chemistry : a European journal</jtitle><addtitle>Chem. Eur. J</addtitle><date>2013-02-18</date><risdate>2013</risdate><volume>19</volume><issue>8</issue><spage>2874</spage><epage>2888</epage><pages>2874-2888</pages><issn>0947-6539</issn><eissn>1521-3765</eissn><coden>CEUJED</coden><abstract>The theoretical background of the formation of N‐heterocyclic oxadiazoline carbenes through a metal‐assisted [2+3]‐dipolar cycloaddition (CA) reaction of nitrones R1CHN(R2)O to isocyanides CNR and the decomposition of these carbenes to imines R1CHNR2 and isocyanates OCNR is discussed. Furthermore, the reaction mechanisms and factors that govern these processes are analyzed in detail. In the absence of a metal, oxadiazoline carbenes should not be accessible due to the high activation energy of their formation and their low thermodynamic stability. The most efficient promotors that could assist the synthesis of these species should be “carbenophilic” metals that form a strong bond with the oxadiazoline heterocycle, but without significant involvement of π‐back donation, namely, AuI, AuIII, PtII, PtIV, ReV, and PdII metal centers. These metals, on the one hand, significantly facilitate the coupling of nitrones with isocyanides and, on the other hand, stabilize the derived carbene heterocycles toward decomposition. The energy of the LUMOCNR and the charge on the N atom of the CN group are principal factors that control the cycloaddition of nitrones to isocyanides. The alkyl‐substituted nitrones and isocyanides are predicted to be more active in the CA reaction than the aryl‐substituted species, and the N,N,C‐alkyloxadiazolines are more stable toward decomposition relative to the aryl derivatives.
Going in circles: The theoretical background of the formation of N‐heterocyclic aminooxycarbenes through a metal‐assisted [2+3]‐cycloaddition of nitrones to isocyanides and of their decomposition to imines and isocyanates is discussed (see scheme).</abstract><cop>Weinheim</cop><pub>WILEY-VCH Verlag</pub><pmid>23296691</pmid><doi>10.1002/chem.201203098</doi><tpages>15</tpages></addata></record> |
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subjects | Carbenes Chemistry Cycloaddition Decomposition Decomposition reactions density functional calculations Derivatives Formations Imines Isocyanates isocyanides N-heterocyclic carbenes reaction mechanisms Theory |
title | Theory of the Formation and Decomposition of N-Heterocyclic Aminooxycarbenes through Metal-Assisted [2+3]-Dipolar Cycloaddition/Retro-Cycloaddition |
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