Synthesis, DFT and antimicrobial activity assays in vitro for novel cis/trans-but-2-enedioic acid esters

•Six novel cis/trans-but-2-enedioic acid esters were synthesized and characterized.•Compound 6a showed the strongest antimicrobial activity against all tested microorganisms.•SAR studies showed that these compounds might possess electrophilic reactivity towards biological nucleophiles. Six novel cis...

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Veröffentlicht in:	Journal of molecular structure 2014-04, Vol.1063, p.226-234
Hauptverfasser:	Ma, Yan-Long, Zhou, Ru-Jin, Zeng, Xing-Ye, An, Ya-Xiong, Qiu, Song-Shan, Nie, Li-Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiinfectives and antibacterials Antimicrobial activity assay Bacteria Cis/trans-but-2-enedioic acid esters DFT studies Esters In vitro testing Lactococcus lactis Microorganisms Molecular structure Nuclear magnetic resonance Phenyls Saccharomyces cerevisiae Salmonidae Synthesis Time–kill assay
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