Matrix rigidity regulates the transition of tumor cells to a bone-destructive phenotype through integrin beta 3 and TGF- beta receptor type II

Cancer patients frequently develop skeletal metastases that significantly impact quality of life. Since bone metastases remain incurable, a clearer understanding of molecular mechanisms regulating skeletal metastases is required to develop new therapeutics that block establishment of tumors in bone....

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Veröffentlicht in:	Biomaterials 2015-09, Vol.64, p.33-44
Hauptverfasser:	Page, Jonathan M, Merkel, Alyssa R, Ruppender, Nazanin S, Guo, Ruijing, Dadwal, Ushashi C, Cannonier, Shellese A, Basu, Sandip, Guelcher, Scott A, Sterling, Julie A
Format:	Artikel
Sprache:	eng
Schlagworte:	Blocking Bones Destruction Gene expression Polyurethane resins Receptors Rigidity Tumors
Online-Zugang:	Volltext
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