Homogeneous generation of iDA neurons with high similarity to bona fide DA neurons using a drug inducible system

Abstract Recent work generating induced dopaminergic (iDA) neurons using direct lineage reprogramming potentially provides a novel platform for the study and treatment Parkinson's disease (PD). However, one of the most important issues for iDA-based applications is the degree to which iDA neuro...

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Veröffentlicht in:	Biomaterials 2015-12, Vol.72, p.152-162
Hauptverfasser:	Park, Hanseul, Kim, Hongwon, Yoo, Junsang, Lee, Jaekwang, Choi, Hwan, Baek, Soonbong, Lee, C. Justin, Kim, Janghwan, Lengner, Christopher J, Sung, Jung-Suk, Kim, Jongpil
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Animals Biomedical materials Cell Lineage - drug effects Cell Shape - drug effects Cellular Reprogramming - drug effects Culture Dentistry Direct lineage reprogramming Dopaminergic Neurons - cytology Dopaminergic Neurons - drug effects Dopaminergic Neurons - metabolism Doxycycline - pharmacology Drugs Electrophysiological Phenomena - drug effects Fibroblasts - drug effects Fibroblasts - metabolism Gene expression Gene expression system Green Fluorescent Proteins - metabolism Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - drug effects Homeodomain Proteins - metabolism Homogeneity Induced neurons Mice Neurons Similarity Surgical implants Transcription Factors - metabolism
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