Total Syntheses and Biological Reassessment of Lactimidomycin, Isomigrastatin and Congener Glutarimide Antibiotics

Lactimidomycin (1) was described in the literature as an exquisitely potent cell migration inhibitor. Encouraged by this claim, we developed a concise and scalable synthesis of this bipartite glutarimide‐macrolide antibiotic, which relies on the power of ring‐closing alkyne metathesis (RCAM) for the...

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Veröffentlicht in:	Chemistry : a European journal 2013-06, Vol.19 (23), p.7370-7383
Hauptverfasser:	Micoine, Kévin, Persich, Peter, Llaveria, Josep, Lam, My-Hanh, Maderna, Andreas, Loganzo, Frank, Fürstner, Alois
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibiotics Biological Cell adhesion & migration Cell death cell migration inhibition Cell Movement - drug effects Cells Chemistry cytotoxicity Decomposition reactions Female Humans Inhibitors Macrolides - chemical synthesis Macrolides - chemistry Macrolides - pharmacology Magnetic Resonance Spectroscopy Metathesis Migration natural products Piperidones - chemical synthesis Piperidones - chemistry Piperidones - pharmacology total synthesis
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