Synthesis of 2,5-Diaryl-Substituted Thiophenes as Helical Mimetics: Towards the Modulation of Islet Amyloid Polypeptide (IAPP) Amyloid Fibril Formation and Cytotoxicity

A range of 2,5‐diarylated thiophenes were synthesised as small molecule mimetics of the α‐helix to modulate the amyloidogenesis and cytotoxic effect of islet amyloid polypeptide (IAPP). 3‐Substituted thiophene‐2‐carboxylic acids were used as key intermediates and functionalised by palladium decarbox...

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Veröffentlicht in:	Chemistry : a European journal 2014-02, Vol.20 (9), p.2522-2528
Hauptverfasser:	Hassanpour, Avid, De Carufel, Carole Anne, Bourgault, Steve, Forgione, Pat
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Amyloid - chemistry Amyloid - toxicity amyloids Chemistry Cytotoxicity CH arylation decarboxylative arylation Formations Helical Insulin-Secreting Cells - chemistry Islet Amyloid Polypeptide - chemistry Islet Amyloid Polypeptide - toxicity Ligands Modulation Molecular Structure peptidomimetics Polypeptides Protein folding Synthesis Thiazoles - chemistry Thiophenes Thiophenes - chemical synthesis Thiophenes - chemistry
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