Oral delivery of bioencapsulated exendin‐4 expressed in chloroplasts lowers blood glucose level in mice and stimulates insulin secretion in beta‐ TC 6 cells

Summary Glucagon-like peptide ( GLP -1) increases insulin secretion but is rapidly degraded (half-life: 2 min in circulation). GLP -1 analogue, exenatide ( B yetta) has a longer half-life (3.3-4 h) with potent insulinotropic effects but requires cold storage, daily abdominal injections with short sh...

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Veröffentlicht in:	Plant biotechnology journal 2013-01, Vol.11 (1), p.77-86
Hauptverfasser:	Kwon, Kwang-Chul, Nityanandam, Ramya, New, James S, Daniell, Henry
Format:	Artikel
Sprache:	eng
Schlagworte:	Glucose Insulin Mice Microorganisms Patients Proteins Secretions Shelf life
Online-Zugang:	Volltext
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