Development of lattice-inserted 5-Fluorouracil-hydroxyapatite nanoparticles as a chemotherapeutic delivery system

Developing an effective vehicle for cancer treatment, hydroxyapatite nanoparticles were fabricated for drug delivery. When 5-Fluorouracil, a major chemoagent, is combined with hydroxyapatite nanocarriers by interclay insertion, the modified hydroxyapatite nanoparticles have superior lysosomal degrad...

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Veröffentlicht in:	Journal of biomaterials applications 2015-10, Vol.30 (4), p.388-397
Hauptverfasser:	Tseng, Ching-Li, Chen, Jung-Chih, Wu, Yu-Chun, Fang, Hsu-Wei, Lin, Feng-Huei, Tang, Tzu-Piao
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Adenocarcinoma - drug therapy Adenocarcinoma of Lung Animals Antimetabolites, Antineoplastic - administration & dosage Antimetabolites, Antineoplastic - pharmacology Assaying Biocompatibility Cancer Cell Line, Tumor Decomposition Diffraction Drug Carriers - chemistry Durapatite - chemistry Fluorouracil - administration & dosage Fluorouracil - pharmacology Humans Hydroxyapatite Lung Neoplasms - drug therapy Mice Nanoparticles Nanoparticles - chemistry Nanoparticles - ultrastructure Nanostructure
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