Inhibition of Amyloid Fibril Growth and Dissolution of Amyloid Fibrils by Curcumin-Gold Nanoparticles

Inhibition of amyloid fibrillation and clearance of amyloid fibrils/plaques are essential for the prevention and treatment of various neurodegenerative disorders involving protein aggregation. Herein, we report curcumin‐functionalized gold nanoparticles (Au‐curcumin) of hydrodynamic diameter 10–25 n...

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Veröffentlicht in:	Chemistry : a European journal 2014-05, Vol.20 (20), p.6184-6191
Hauptverfasser:	Palmal, Sharbari, Maity, Amit Ranjan, Singh, Brijesh Kumar, Basu, Sreetama, Jana, Nihar R., Jana, Nikhil R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Amino Acid Sequence Amyloid - antagonists & inhibitors Amyloid - chemistry Amyloid - metabolism Amyloid - ultrastructure amyloid beta-peptides Amyloid beta-Peptides - antagonists & inhibitors Amyloid beta-Peptides - chemistry Amyloid beta-Peptides - metabolism Amyloid beta-Peptides - ultrastructure amyloid fibrils Chemistry curcumin Curcumin - chemistry Curcumin - pharmacology Disintegration Dissolution fibril dissolution Fibrillation Gold Gold - chemistry Gold - pharmacology gold nanoparticles Humans Inhibition Molecular Sequence Data Nanoparticles Nanoparticles - chemistry Nanoparticles - ultrastructure Nanostructure neurochemistry Protein folding Proteins Solubility - drug effects
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