Copper-Catalyzed Trifluoromethylation and Cyclization of Aromatic-Sulfonyl-Group-Tethered Alkenes for the Construction of 1,2-Benzothiazinane Dioxide Type Compounds

A multi‐talented system: An efficient copper‐catalyzed tandem trifluoromethylation/annulation of an electron‐deficient aromatic ring has been developed. This method provides a powerful and straightforward way to synthesize trifluoromethylated 1,2‐benzothiazinane dioxides under mild conditions (see s...

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Veröffentlicht in:	Chemistry : a European journal 2013-12, Vol.19 (50), p.16910-16915
Hauptverfasser:	Dong, Xiang, Sang, Rui, Wang, Qiang, Tang, Xiang-Ying, Shi, Min
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkenes Alkenes - chemistry Aromatic compounds benzothiazinane Catalysis Chemical reactions Chemistry Construction copper Copper - chemistry Cyclization Dioxides homogeneous catalysis Isotopic labeling Molecular Structure Organic chemistry radicals Thiazines - chemistry trifluoromethylation
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container_title	Chemistry : a European journal
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creator	Dong, Xiang Sang, Rui Wang, Qiang Tang, Xiang-Ying Shi, Min
description	A multi‐talented system: An efficient copper‐catalyzed tandem trifluoromethylation/annulation of an electron‐deficient aromatic ring has been developed. This method provides a powerful and straightforward way to synthesize trifluoromethylated 1,2‐benzothiazinane dioxides under mild conditions (see scheme). The mechanism was investigated by a series of kinetic experiments and isotopic labeling studies.
doi_str_mv	10.1002/chem.201303623
format	Article
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subjects	Alkenes Alkenes - chemistry Aromatic compounds benzothiazinane Catalysis Chemical reactions Chemistry Construction copper Copper - chemistry Cyclization Dioxides homogeneous catalysis Isotopic labeling Molecular Structure Organic chemistry radicals Thiazines - chemistry trifluoromethylation
title	Copper-Catalyzed Trifluoromethylation and Cyclization of Aromatic-Sulfonyl-Group-Tethered Alkenes for the Construction of 1,2-Benzothiazinane Dioxide Type Compounds
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