Hyaluronic acid and polyethylenimine self-assembled polyion complexes as pH-sensitive drug carrier for cancer therapy
•The PICs had negatively charged surface and were stable in physiological milieu.•The PICs could load small molecules and induce targeted drug delivery.•The PICs could behave pH responsive drug release behavior. In this study, a series of polyion complexes (PICs) were prepared via electrostatic inte...
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| Veröffentlicht in: | Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2015-10, Vol.134, p.81-87 |
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| creator | Chen, Jing-Xiao Wang, Min Tian, Hui-Hui Chen, Jing-Hua |
| description | •The PICs had negatively charged surface and were stable in physiological milieu.•The PICs could load small molecules and induce targeted drug delivery.•The PICs could behave pH responsive drug release behavior.
In this study, a series of polyion complexes (PICs) were prepared via electrostatic interaction between hyaluronic acid–histidine conjugate (HH) and polyethylenimine–histidine conjugate (PH). These PICs with the average size ranging from 410.5nm to 98.5nm at different weight ratios of HH/PH were able to encapsulate doxorubicin (DOX) as the model antitumor drug. The PICs at the weight ratio of 4:1 had negative surface charge and were of good dispersity and stability in the solution containing serum. In vitro drug release assay demonstrated that the DOX release rate were higher at acidic pH showing a controllable property. These HA coated PICs could targetedly deliver DOX to B16F10 tumor cells, showing improved antitumor activity. |
| doi_str_mv | 10.1016/j.colsurfb.2015.06.039 |
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In this study, a series of polyion complexes (PICs) were prepared via electrostatic interaction between hyaluronic acid–histidine conjugate (HH) and polyethylenimine–histidine conjugate (PH). These PICs with the average size ranging from 410.5nm to 98.5nm at different weight ratios of HH/PH were able to encapsulate doxorubicin (DOX) as the model antitumor drug. The PICs at the weight ratio of 4:1 had negative surface charge and were of good dispersity and stability in the solution containing serum. In vitro drug release assay demonstrated that the DOX release rate were higher at acidic pH showing a controllable property. These HA coated PICs could targetedly deliver DOX to B16F10 tumor cells, showing improved antitumor activity.</description><identifier>ISSN: 0927-7765</identifier><identifier>EISSN: 1873-4367</identifier><identifier>DOI: 10.1016/j.colsurfb.2015.06.039</identifier><identifier>PMID: 26149947</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Antibiotics, Antineoplastic - administration & dosage ; Antibiotics, Antineoplastic - chemistry ; CD44 receptor ; Cell Line, Tumor ; Conjugates ; Doxorubicin - administration & dosage ; Doxorubicin - chemistry ; Drug Carriers ; Drug delivery systems ; Drugs ; Histidine ; Hyaluronic acid ; Hyaluronic Acid - chemistry ; Hydrogen-Ion Concentration ; Hydroxyapatite ; In vitro testing ; Ions ; Melanoma, Experimental - drug therapy ; Melanoma, Experimental - pathology ; Mice ; Microscopy, Electron, Transmission ; NIH 3T3 Cells ; pH sensitive ; Polyethyleneimine - chemistry ; Polyethylenimine ; Polyion complexes ; Therapy</subject><ispartof>Colloids and surfaces, B, Biointerfaces, 2015-10, Vol.134, p.81-87</ispartof><rights>2015 Elsevier B.V.</rights><rights>Copyright © 2015 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c500t-19813cfb1ff2399996f4c841aa8abd2cfaac54c9cf5438b411877dc28df52d3d3</citedby><cites>FETCH-LOGICAL-c500t-19813cfb1ff2399996f4c841aa8abd2cfaac54c9cf5438b411877dc28df52d3d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.colsurfb.2015.06.039$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26149947$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Jing-Xiao</creatorcontrib><creatorcontrib>Wang, Min</creatorcontrib><creatorcontrib>Tian, Hui-Hui</creatorcontrib><creatorcontrib>Chen, Jing-Hua</creatorcontrib><title>Hyaluronic acid and polyethylenimine self-assembled polyion complexes as pH-sensitive drug carrier for cancer therapy</title><title>Colloids and surfaces, B, Biointerfaces</title><addtitle>Colloids Surf B Biointerfaces</addtitle><description>•The PICs had negatively charged surface and were stable in physiological milieu.•The PICs could load small molecules and induce targeted drug delivery.•The PICs could behave pH responsive drug release behavior.
In this study, a series of polyion complexes (PICs) were prepared via electrostatic interaction between hyaluronic acid–histidine conjugate (HH) and polyethylenimine–histidine conjugate (PH). These PICs with the average size ranging from 410.5nm to 98.5nm at different weight ratios of HH/PH were able to encapsulate doxorubicin (DOX) as the model antitumor drug. The PICs at the weight ratio of 4:1 had negative surface charge and were of good dispersity and stability in the solution containing serum. In vitro drug release assay demonstrated that the DOX release rate were higher at acidic pH showing a controllable property. These HA coated PICs could targetedly deliver DOX to B16F10 tumor cells, showing improved antitumor activity.</description><subject>Animals</subject><subject>Antibiotics, Antineoplastic - administration & dosage</subject><subject>Antibiotics, Antineoplastic - chemistry</subject><subject>CD44 receptor</subject><subject>Cell Line, Tumor</subject><subject>Conjugates</subject><subject>Doxorubicin - administration & dosage</subject><subject>Doxorubicin - chemistry</subject><subject>Drug Carriers</subject><subject>Drug delivery systems</subject><subject>Drugs</subject><subject>Histidine</subject><subject>Hyaluronic acid</subject><subject>Hyaluronic Acid - chemistry</subject><subject>Hydrogen-Ion Concentration</subject><subject>Hydroxyapatite</subject><subject>In vitro testing</subject><subject>Ions</subject><subject>Melanoma, Experimental - drug therapy</subject><subject>Melanoma, Experimental - pathology</subject><subject>Mice</subject><subject>Microscopy, Electron, Transmission</subject><subject>NIH 3T3 Cells</subject><subject>pH sensitive</subject><subject>Polyethyleneimine - chemistry</subject><subject>Polyethylenimine</subject><subject>Polyion complexes</subject><subject>Therapy</subject><issn>0927-7765</issn><issn>1873-4367</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcFuFSEUhonR2NvqKzQs3cwIAwPMTtOo16RJN7omDBwsN8wwwkzjvL00t3Vr2XASvnNO-D-ErilpKaHi46m1KZYt-7HtCO1bIlrChlfoQJVkDWdCvkYHMnSykVL0F-iylBMhpONUvkUXnaB8GLg8oO24m7jlNAeLjQ0Om9nhJcUd1vs9whymMAMuEH1jSoFpjHB-D2nGNk1LhD9QsCl4OTYF5hLW8ADY5e0XtibnABn7lGs921qu95DNsr9Db7yJBd4_3Vfo59cvP26Oze3dt-83n28b2xOyNnRQlFk_Uu87NtQjPLeKU2OUGV1nvTG253awvudMjZzWz0tnO-V83znm2BX6cJ675PR7g7LqKRQLMZoZ0lY0lVIRwjjrX4ByoaTq-fAClHZ1bi9YRcUZtTmVksHrJYfJ5F1Toh9F6pN-FqkfRWoidBVZG6-fdmzjBO5f27O5Cnw6A1Dze6gx62ID1JBdyGBX7VL4346_m1u04w</recordid><startdate>20151001</startdate><enddate>20151001</enddate><creator>Chen, Jing-Xiao</creator><creator>Wang, Min</creator><creator>Tian, Hui-Hui</creator><creator>Chen, Jing-Hua</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20151001</creationdate><title>Hyaluronic acid and polyethylenimine self-assembled polyion complexes as pH-sensitive drug carrier for cancer therapy</title><author>Chen, Jing-Xiao ; Wang, Min ; Tian, Hui-Hui ; Chen, Jing-Hua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c500t-19813cfb1ff2399996f4c841aa8abd2cfaac54c9cf5438b411877dc28df52d3d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Antibiotics, Antineoplastic - administration & dosage</topic><topic>Antibiotics, Antineoplastic - chemistry</topic><topic>CD44 receptor</topic><topic>Cell Line, Tumor</topic><topic>Conjugates</topic><topic>Doxorubicin - administration & dosage</topic><topic>Doxorubicin - chemistry</topic><topic>Drug Carriers</topic><topic>Drug delivery systems</topic><topic>Drugs</topic><topic>Histidine</topic><topic>Hyaluronic acid</topic><topic>Hyaluronic Acid - chemistry</topic><topic>Hydrogen-Ion Concentration</topic><topic>Hydroxyapatite</topic><topic>In vitro testing</topic><topic>Ions</topic><topic>Melanoma, Experimental - drug therapy</topic><topic>Melanoma, Experimental - pathology</topic><topic>Mice</topic><topic>Microscopy, Electron, Transmission</topic><topic>NIH 3T3 Cells</topic><topic>pH sensitive</topic><topic>Polyethyleneimine - chemistry</topic><topic>Polyethylenimine</topic><topic>Polyion complexes</topic><topic>Therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Jing-Xiao</creatorcontrib><creatorcontrib>Wang, Min</creatorcontrib><creatorcontrib>Tian, Hui-Hui</creatorcontrib><creatorcontrib>Chen, Jing-Hua</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Colloids and surfaces, B, Biointerfaces</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Jing-Xiao</au><au>Wang, Min</au><au>Tian, Hui-Hui</au><au>Chen, Jing-Hua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hyaluronic acid and polyethylenimine self-assembled polyion complexes as pH-sensitive drug carrier for cancer therapy</atitle><jtitle>Colloids and surfaces, B, Biointerfaces</jtitle><addtitle>Colloids Surf B Biointerfaces</addtitle><date>2015-10-01</date><risdate>2015</risdate><volume>134</volume><spage>81</spage><epage>87</epage><pages>81-87</pages><issn>0927-7765</issn><eissn>1873-4367</eissn><abstract>•The PICs had negatively charged surface and were stable in physiological milieu.•The PICs could load small molecules and induce targeted drug delivery.•The PICs could behave pH responsive drug release behavior.
In this study, a series of polyion complexes (PICs) were prepared via electrostatic interaction between hyaluronic acid–histidine conjugate (HH) and polyethylenimine–histidine conjugate (PH). These PICs with the average size ranging from 410.5nm to 98.5nm at different weight ratios of HH/PH were able to encapsulate doxorubicin (DOX) as the model antitumor drug. The PICs at the weight ratio of 4:1 had negative surface charge and were of good dispersity and stability in the solution containing serum. In vitro drug release assay demonstrated that the DOX release rate were higher at acidic pH showing a controllable property. These HA coated PICs could targetedly deliver DOX to B16F10 tumor cells, showing improved antitumor activity.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>26149947</pmid><doi>10.1016/j.colsurfb.2015.06.039</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Antibiotics, Antineoplastic - administration & dosage Antibiotics, Antineoplastic - chemistry CD44 receptor Cell Line, Tumor Conjugates Doxorubicin - administration & dosage Doxorubicin - chemistry Drug Carriers Drug delivery systems Drugs Histidine Hyaluronic acid Hyaluronic Acid - chemistry Hydrogen-Ion Concentration Hydroxyapatite In vitro testing Ions Melanoma, Experimental - drug therapy Melanoma, Experimental - pathology Mice Microscopy, Electron, Transmission NIH 3T3 Cells pH sensitive Polyethyleneimine - chemistry Polyethylenimine Polyion complexes Therapy |
| title | Hyaluronic acid and polyethylenimine self-assembled polyion complexes as pH-sensitive drug carrier for cancer therapy |
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