BRAF mutation may have different prognostic implications in early- and late-stage colorectal cancer
The prognostic implication of BRAF mutant colorectal cancer remains paradoxical. Records of BRAF mutant and wild-type colorectal cancer patients at all stages were reviewed. Clinicopathologic features, including microsatellite instability, CpG islands methylator phenotype, and overall survival, of t...
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| Veröffentlicht in: | Medical oncology (Northwood, London, England) London, England), 2016-05, Vol.33 (5), p.39-39, Article 39 |
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| creator | Chen, Kuo-Hsing Lin, Yu-Lin Liau, Jau-Yu Tsai, Jia-Huei Tseng, Li-Hui Lin, Liang-In Liang, Jin-Tung Lin, Been-Ren Hung, Ji-Shiang Chang, Yih-Leong Yeh, Kun-Huei Cheng, Ann-Lii |
| description | The prognostic implication of
BRAF
mutant colorectal cancer remains paradoxical. Records of
BRAF
mutant and wild-type colorectal cancer patients at all stages were reviewed. Clinicopathologic features, including microsatellite instability, CpG islands methylator phenotype, and overall survival, of these patients were analyzed. Between 2005 and 2013, 428 colorectal cancer patients were enrolled in this study. The overall survival between
BRAF
mutant and wild-type patients with early-stage (stages I and II) colorectal cancer differed nonsignificantly (
P
= 0.99). By contrast, in late-stage (stages III and IV) patients, the median overall survival of
BRAF
mutant patients (
N
= 25) was significantly poorer than that of
BRAF
wild-type (
N
= 207) patients (
BRAF
mutant: 21.3 months (95 % confidence interval [CI] 7.1–35.5);
BRAF
wild-type: 53.5 months (95 % CI 37.5–69.5),
P
|
| doi_str_mv | 10.1007/s12032-016-0756-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1777987028</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1777987028</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-dec64a87326bf1b18f081a541a9a0f8bc17dd993712bae3a8594d72328c79a783</originalsourceid><addsrcrecordid>eNp1kUFr3DAQhUVIyaZJfkAuRZBLLmo10tqSj2lI0kIgUBLITYzl8dbBlreSHNh_X292W0ohpxmYb9485jF2DvIzSGm-JFBSKyGhFNIUpSgP2DEURSVAw_Ph3OvCCFmUcsE-pvQipYJCVUdsoYzUS1XqY-a__ri65cOUMXdj4ANu-E98Jd50bUuRQubrOK7CmHLneTes-86_kYl3gRPGfiM4hob3mEmkjCvifuzHSD5jzz0GT_GUfWixT3S2ryfs6fbm8fqbuH-4-359dS-8NiqLhny5RGu0KusWarCttIDFErBC2drag2maqtIGVI2k0RbVsjFKK-tNhcbqE3a5050t_5ooZTd0yVPfY6BxSg6MMZU1Um3Ri__Ql3GKYXb3RikLSpuZgh3l45hSpNatYzdg3DiQbpuA2yXg5gTcNgFXzjuf9spTPVDzd-PPy2dA7YA0j8KK4j-n31X9Dc1gkGg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1777281237</pqid></control><display><type>article</type><title>BRAF mutation may have different prognostic implications in early- and late-stage colorectal cancer</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Chen, Kuo-Hsing ; Lin, Yu-Lin ; Liau, Jau-Yu ; Tsai, Jia-Huei ; Tseng, Li-Hui ; Lin, Liang-In ; Liang, Jin-Tung ; Lin, Been-Ren ; Hung, Ji-Shiang ; Chang, Yih-Leong ; Yeh, Kun-Huei ; Cheng, Ann-Lii</creator><creatorcontrib>Chen, Kuo-Hsing ; Lin, Yu-Lin ; Liau, Jau-Yu ; Tsai, Jia-Huei ; Tseng, Li-Hui ; Lin, Liang-In ; Liang, Jin-Tung ; Lin, Been-Ren ; Hung, Ji-Shiang ; Chang, Yih-Leong ; Yeh, Kun-Huei ; Cheng, Ann-Lii</creatorcontrib><description>The prognostic implication of
BRAF
mutant colorectal cancer remains paradoxical. Records of
BRAF
mutant and wild-type colorectal cancer patients at all stages were reviewed. Clinicopathologic features, including microsatellite instability, CpG islands methylator phenotype, and overall survival, of these patients were analyzed. Between 2005 and 2013, 428 colorectal cancer patients were enrolled in this study. The overall survival between
BRAF
mutant and wild-type patients with early-stage (stages I and II) colorectal cancer differed nonsignificantly (
P
= 0.99). By contrast, in late-stage (stages III and IV) patients, the median overall survival of
BRAF
mutant patients (
N
= 25) was significantly poorer than that of
BRAF
wild-type (
N
= 207) patients (
BRAF
mutant: 21.3 months (95 % confidence interval [CI] 7.1–35.5);
BRAF
wild-type: 53.5 months (95 % CI 37.5–69.5),
P
< 0.0001). In early-stage patients, we found that
BRAF
mutation was significantly associated with CpG island methylator phenotype-positive (
P
< 0.001), and microsatellite instability-high status (
P
= 0.0013). Conversely, in late-stage patients,
BRAF
mutation was significantly associated with CpG island methylator phenotype-positive (
P
= 0.0015) and the right-side colon (
P
= 0.014).
BRAF
mutation may have different prognostic implications in early- and late-stage colorectal cancer.</description><identifier>ISSN: 1357-0560</identifier><identifier>EISSN: 1559-131X</identifier><identifier>DOI: 10.1007/s12032-016-0756-6</identifier><identifier>PMID: 27034263</identifier><identifier>CODEN: MONCEZ</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Aged ; Colorectal cancer ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms - mortality ; Colorectal Neoplasms - pathology ; CpG Islands ; DNA Methylation ; Female ; Hematology ; Humans ; Internal Medicine ; Kaplan-Meier Estimate ; Male ; Medicine ; Medicine & Public Health ; Microsatellite Instability ; Middle Aged ; Multivariate Analysis ; Mutation ; Oncology ; Original Paper ; Pathology ; Prognosis ; Proto-Oncogene Proteins B-raf - genetics</subject><ispartof>Medical oncology (Northwood, London, England), 2016-05, Vol.33 (5), p.39-39, Article 39</ispartof><rights>Springer Science+Business Media New York 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-dec64a87326bf1b18f081a541a9a0f8bc17dd993712bae3a8594d72328c79a783</citedby><cites>FETCH-LOGICAL-c372t-dec64a87326bf1b18f081a541a9a0f8bc17dd993712bae3a8594d72328c79a783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12032-016-0756-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12032-016-0756-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27034263$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Kuo-Hsing</creatorcontrib><creatorcontrib>Lin, Yu-Lin</creatorcontrib><creatorcontrib>Liau, Jau-Yu</creatorcontrib><creatorcontrib>Tsai, Jia-Huei</creatorcontrib><creatorcontrib>Tseng, Li-Hui</creatorcontrib><creatorcontrib>Lin, Liang-In</creatorcontrib><creatorcontrib>Liang, Jin-Tung</creatorcontrib><creatorcontrib>Lin, Been-Ren</creatorcontrib><creatorcontrib>Hung, Ji-Shiang</creatorcontrib><creatorcontrib>Chang, Yih-Leong</creatorcontrib><creatorcontrib>Yeh, Kun-Huei</creatorcontrib><creatorcontrib>Cheng, Ann-Lii</creatorcontrib><title>BRAF mutation may have different prognostic implications in early- and late-stage colorectal cancer</title><title>Medical oncology (Northwood, London, England)</title><addtitle>Med Oncol</addtitle><addtitle>Med Oncol</addtitle><description>The prognostic implication of
BRAF
mutant colorectal cancer remains paradoxical. Records of
BRAF
mutant and wild-type colorectal cancer patients at all stages were reviewed. Clinicopathologic features, including microsatellite instability, CpG islands methylator phenotype, and overall survival, of these patients were analyzed. Between 2005 and 2013, 428 colorectal cancer patients were enrolled in this study. The overall survival between
BRAF
mutant and wild-type patients with early-stage (stages I and II) colorectal cancer differed nonsignificantly (
P
= 0.99). By contrast, in late-stage (stages III and IV) patients, the median overall survival of
BRAF
mutant patients (
N
= 25) was significantly poorer than that of
BRAF
wild-type (
N
= 207) patients (
BRAF
mutant: 21.3 months (95 % confidence interval [CI] 7.1–35.5);
BRAF
wild-type: 53.5 months (95 % CI 37.5–69.5),
P
< 0.0001). In early-stage patients, we found that
BRAF
mutation was significantly associated with CpG island methylator phenotype-positive (
P
< 0.001), and microsatellite instability-high status (
P
= 0.0013). Conversely, in late-stage patients,
BRAF
mutation was significantly associated with CpG island methylator phenotype-positive (
P
= 0.0015) and the right-side colon (
P
= 0.014).
BRAF
mutation may have different prognostic implications in early- and late-stage colorectal cancer.</description><subject>Aged</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Colorectal Neoplasms - mortality</subject><subject>Colorectal Neoplasms - pathology</subject><subject>CpG Islands</subject><subject>DNA Methylation</subject><subject>Female</subject><subject>Hematology</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microsatellite Instability</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Mutation</subject><subject>Oncology</subject><subject>Original Paper</subject><subject>Pathology</subject><subject>Prognosis</subject><subject>Proto-Oncogene Proteins B-raf - genetics</subject><issn>1357-0560</issn><issn>1559-131X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kUFr3DAQhUVIyaZJfkAuRZBLLmo10tqSj2lI0kIgUBLITYzl8dbBlreSHNh_X292W0ohpxmYb9485jF2DvIzSGm-JFBSKyGhFNIUpSgP2DEURSVAw_Ph3OvCCFmUcsE-pvQipYJCVUdsoYzUS1XqY-a__ri65cOUMXdj4ANu-E98Jd50bUuRQubrOK7CmHLneTes-86_kYl3gRPGfiM4hob3mEmkjCvifuzHSD5jzz0GT_GUfWixT3S2ryfs6fbm8fqbuH-4-359dS-8NiqLhny5RGu0KusWarCttIDFErBC2drag2maqtIGVI2k0RbVsjFKK-tNhcbqE3a5050t_5ooZTd0yVPfY6BxSg6MMZU1Um3Ri__Ql3GKYXb3RikLSpuZgh3l45hSpNatYzdg3DiQbpuA2yXg5gTcNgFXzjuf9spTPVDzd-PPy2dA7YA0j8KK4j-n31X9Dc1gkGg</recordid><startdate>20160501</startdate><enddate>20160501</enddate><creator>Chen, Kuo-Hsing</creator><creator>Lin, Yu-Lin</creator><creator>Liau, Jau-Yu</creator><creator>Tsai, Jia-Huei</creator><creator>Tseng, Li-Hui</creator><creator>Lin, Liang-In</creator><creator>Liang, Jin-Tung</creator><creator>Lin, Been-Ren</creator><creator>Hung, Ji-Shiang</creator><creator>Chang, Yih-Leong</creator><creator>Yeh, Kun-Huei</creator><creator>Cheng, Ann-Lii</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20160501</creationdate><title>BRAF mutation may have different prognostic implications in early- and late-stage colorectal cancer</title><author>Chen, Kuo-Hsing ; Lin, Yu-Lin ; Liau, Jau-Yu ; Tsai, Jia-Huei ; Tseng, Li-Hui ; Lin, Liang-In ; Liang, Jin-Tung ; Lin, Been-Ren ; Hung, Ji-Shiang ; Chang, Yih-Leong ; Yeh, Kun-Huei ; Cheng, Ann-Lii</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-dec64a87326bf1b18f081a541a9a0f8bc17dd993712bae3a8594d72328c79a783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Colorectal cancer</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Colorectal Neoplasms - mortality</topic><topic>Colorectal Neoplasms - pathology</topic><topic>CpG Islands</topic><topic>DNA Methylation</topic><topic>Female</topic><topic>Hematology</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Microsatellite Instability</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Mutation</topic><topic>Oncology</topic><topic>Original Paper</topic><topic>Pathology</topic><topic>Prognosis</topic><topic>Proto-Oncogene Proteins B-raf - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Kuo-Hsing</creatorcontrib><creatorcontrib>Lin, Yu-Lin</creatorcontrib><creatorcontrib>Liau, Jau-Yu</creatorcontrib><creatorcontrib>Tsai, Jia-Huei</creatorcontrib><creatorcontrib>Tseng, Li-Hui</creatorcontrib><creatorcontrib>Lin, Liang-In</creatorcontrib><creatorcontrib>Liang, Jin-Tung</creatorcontrib><creatorcontrib>Lin, Been-Ren</creatorcontrib><creatorcontrib>Hung, Ji-Shiang</creatorcontrib><creatorcontrib>Chang, Yih-Leong</creatorcontrib><creatorcontrib>Yeh, Kun-Huei</creatorcontrib><creatorcontrib>Cheng, Ann-Lii</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Medical oncology (Northwood, London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Kuo-Hsing</au><au>Lin, Yu-Lin</au><au>Liau, Jau-Yu</au><au>Tsai, Jia-Huei</au><au>Tseng, Li-Hui</au><au>Lin, Liang-In</au><au>Liang, Jin-Tung</au><au>Lin, Been-Ren</au><au>Hung, Ji-Shiang</au><au>Chang, Yih-Leong</au><au>Yeh, Kun-Huei</au><au>Cheng, Ann-Lii</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>BRAF mutation may have different prognostic implications in early- and late-stage colorectal cancer</atitle><jtitle>Medical oncology (Northwood, London, England)</jtitle><stitle>Med Oncol</stitle><addtitle>Med Oncol</addtitle><date>2016-05-01</date><risdate>2016</risdate><volume>33</volume><issue>5</issue><spage>39</spage><epage>39</epage><pages>39-39</pages><artnum>39</artnum><issn>1357-0560</issn><eissn>1559-131X</eissn><coden>MONCEZ</coden><abstract>The prognostic implication of
BRAF
mutant colorectal cancer remains paradoxical. Records of
BRAF
mutant and wild-type colorectal cancer patients at all stages were reviewed. Clinicopathologic features, including microsatellite instability, CpG islands methylator phenotype, and overall survival, of these patients were analyzed. Between 2005 and 2013, 428 colorectal cancer patients were enrolled in this study. The overall survival between
BRAF
mutant and wild-type patients with early-stage (stages I and II) colorectal cancer differed nonsignificantly (
P
= 0.99). By contrast, in late-stage (stages III and IV) patients, the median overall survival of
BRAF
mutant patients (
N
= 25) was significantly poorer than that of
BRAF
wild-type (
N
= 207) patients (
BRAF
mutant: 21.3 months (95 % confidence interval [CI] 7.1–35.5);
BRAF
wild-type: 53.5 months (95 % CI 37.5–69.5),
P
< 0.0001). In early-stage patients, we found that
BRAF
mutation was significantly associated with CpG island methylator phenotype-positive (
P
< 0.001), and microsatellite instability-high status (
P
= 0.0013). Conversely, in late-stage patients,
BRAF
mutation was significantly associated with CpG island methylator phenotype-positive (
P
= 0.0015) and the right-side colon (
P
= 0.014).
BRAF
mutation may have different prognostic implications in early- and late-stage colorectal cancer.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>27034263</pmid><doi>10.1007/s12032-016-0756-6</doi><tpages>1</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Medical oncology (Northwood, London, England), 2016-05, Vol.33 (5), p.39-39, Article 39 |
| issn | 1357-0560 1559-131X |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Aged Colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology CpG Islands DNA Methylation Female Hematology Humans Internal Medicine Kaplan-Meier Estimate Male Medicine Medicine & Public Health Microsatellite Instability Middle Aged Multivariate Analysis Mutation Oncology Original Paper Pathology Prognosis Proto-Oncogene Proteins B-raf - genetics |
| title | BRAF mutation may have different prognostic implications in early- and late-stage colorectal cancer |
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