Decarboxylative Halogenation and Cyanation of Electron-Deficient Aryl Carboxylic Acids via Cu Mediator as Well as Electron-Rich Ones through Pd Catalyst under Aerobic Conditions
Simple strategies for decarboxylative functionalizations of electron-deficient benzoic acids via using Cu(I) as promoter and electron-rich ones by employing Pd(II) as catalyst under aerobic conditions have been established, which lead to smooth synthesis of aryl halides (−I, Br, and Cl) through th...
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| Veröffentlicht in: | Journal of organic chemistry 2016-04, Vol.81 (7), p.2794-2803 |
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| container_end_page | 2803 |
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| container_issue | 7 |
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| container_title | Journal of organic chemistry |
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| creator | Fu, Zhengjiang Li, Zhaojie Song, Yuanyuan Yang, Ruchun Liu, Yanzhu Cai, Hu |
| description | Simple strategies for decarboxylative functionalizations of electron-deficient benzoic acids via using Cu(I) as promoter and electron-rich ones by employing Pd(II) as catalyst under aerobic conditions have been established, which lead to smooth synthesis of aryl halides (−I, Br, and Cl) through the decarboxylative functionalization of benzoic acids with readily available halogen sources CuX (X = I, Br, Cl), and easy preparation of benzonitriles from decarboxylative cyanation of aryl carboxylic acids with nontoxic and low-cost K4Fe(CN)6 under an oxygen atmosphere for the first time. |
| doi_str_mv | 10.1021/acs.joc.5b02873 |
| format | Article |
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| title | Decarboxylative Halogenation and Cyanation of Electron-Deficient Aryl Carboxylic Acids via Cu Mediator as Well as Electron-Rich Ones through Pd Catalyst under Aerobic Conditions |
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