The effectiveness of leucine on muscle protein synthesis, lean body mass and leg lean mass accretion in older people: a systematic review and meta-analysis
In the present study, we performed a meta-analysis to assess the ability of leucine supplementation to increase the muscle protein fraction synthetic rate and to augment lean body mass or leg lean mass in elderly patients. A literature search was conducted on Medline, Cochrane, EMBASE and Google Sch...
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| Veröffentlicht in: | British journal of nutrition 2015-01, Vol.113 (1), p.25-34 |
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| creator | Xu, Zhe-rong Tan, Zhong-ju Zhang, Qin Gui, Qi-feng Yang, Yun-mei |
| description | In the present study, we performed a meta-analysis to assess the ability of leucine supplementation to increase the muscle protein fraction synthetic rate and to augment lean body mass or leg lean mass in elderly patients. A literature search was conducted on Medline, Cochrane, EMBASE and Google Scholar databases up to 31 December 2013 for clinical trials that investigated the administration of leucine as a nutrient that affects muscle protein metabolism and muscle mass in elderly subjects. The included studies were randomised controlled trials. The primary outcome for the meta-analysis was the protein fractional synthetic rate. Secondary outcomes included lean body mass and leg lean mass. A total of nine studies were included in the meta-analysis. The results showed that the muscle protein fractional synthetic rate after intervention significantly increased in the leucine group compared with the control group (pooled standardised difference in mean changes 1·08, 95 % CI 0·50, 1·67; P |
| doi_str_mv | 10.1017/S0007114514002475 |
| format | Article |
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A literature search was conducted on Medline, Cochrane, EMBASE and Google Scholar databases up to 31 December 2013 for clinical trials that investigated the administration of leucine as a nutrient that affects muscle protein metabolism and muscle mass in elderly subjects. The included studies were randomised controlled trials. The primary outcome for the meta-analysis was the protein fractional synthetic rate. Secondary outcomes included lean body mass and leg lean mass. A total of nine studies were included in the meta-analysis. The results showed that the muscle protein fractional synthetic rate after intervention significantly increased in the leucine group compared with the control group (pooled standardised difference in mean changes 1·08, 95 % CI 0·50, 1·67; P< 0·001). No difference was found between the groups in relation to lean body mass (pooled standardised difference in mean changes 0·18, 95 % CI − 0·18, 0·54; P= 0·318) or leg lean mass (pooled standardised difference in mean changes 0·006, 95 % CI − 0·32, 0·44; P= 0·756). These findings suggest that leucine supplementation is useful to address the age-related decline in muscle mass in elderly individuals, as it increases the muscle protein fractional synthetic rate.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1017/S0007114514002475</identifier><identifier>PMID: 25234223</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Accretion ; Aged ; Amino acids ; Body Composition ; Body mass ; Body Mass Index ; Databases, Factual ; Dietary Supplements ; Humans ; Leg - anatomy & histology ; Leucine - administration & dosage ; Muscle Proteins - biosynthesis ; Muscle Proteins - drug effects ; Muscle, Skeletal - drug effects ; Muscle, Skeletal - metabolism ; Muscular system ; Older people ; Protein synthesis ; Proteins ; Randomized Controlled Trials as Topic ; Systematic review ; Systematic Review with Meta-Analysis</subject><ispartof>British journal of nutrition, 2015-01, Vol.113 (1), p.25-34</ispartof><rights>Copyright © The Authors 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c600t-1822275d217e52290c237da4a259f928530e6126b32c9c1d882f4d17ee090b423</citedby><cites>FETCH-LOGICAL-c600t-1822275d217e52290c237da4a259f928530e6126b32c9c1d882f4d17ee090b423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0007114514002475/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,776,780,27901,27902,55603</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25234223$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Zhe-rong</creatorcontrib><creatorcontrib>Tan, Zhong-ju</creatorcontrib><creatorcontrib>Zhang, Qin</creatorcontrib><creatorcontrib>Gui, Qi-feng</creatorcontrib><creatorcontrib>Yang, Yun-mei</creatorcontrib><title>The effectiveness of leucine on muscle protein synthesis, lean body mass and leg lean mass accretion in older people: a systematic review and meta-analysis</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>In the present study, we performed a meta-analysis to assess the ability of leucine supplementation to increase the muscle protein fraction synthetic rate and to augment lean body mass or leg lean mass in elderly patients. A literature search was conducted on Medline, Cochrane, EMBASE and Google Scholar databases up to 31 December 2013 for clinical trials that investigated the administration of leucine as a nutrient that affects muscle protein metabolism and muscle mass in elderly subjects. The included studies were randomised controlled trials. The primary outcome for the meta-analysis was the protein fractional synthetic rate. Secondary outcomes included lean body mass and leg lean mass. A total of nine studies were included in the meta-analysis. The results showed that the muscle protein fractional synthetic rate after intervention significantly increased in the leucine group compared with the control group (pooled standardised difference in mean changes 1·08, 95 % CI 0·50, 1·67; P< 0·001). No difference was found between the groups in relation to lean body mass (pooled standardised difference in mean changes 0·18, 95 % CI − 0·18, 0·54; P= 0·318) or leg lean mass (pooled standardised difference in mean changes 0·006, 95 % CI − 0·32, 0·44; P= 0·756). These findings suggest that leucine supplementation is useful to address the age-related decline in muscle mass in elderly individuals, as it increases the muscle protein fractional synthetic rate.</description><subject>Accretion</subject><subject>Aged</subject><subject>Amino acids</subject><subject>Body Composition</subject><subject>Body mass</subject><subject>Body Mass Index</subject><subject>Databases, Factual</subject><subject>Dietary Supplements</subject><subject>Humans</subject><subject>Leg - anatomy & histology</subject><subject>Leucine - administration & dosage</subject><subject>Muscle Proteins - biosynthesis</subject><subject>Muscle Proteins - drug effects</subject><subject>Muscle, Skeletal - drug effects</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Muscular system</subject><subject>Older people</subject><subject>Protein synthesis</subject><subject>Proteins</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Systematic review</subject><subject>Systematic Review with Meta-Analysis</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kcFu1DAQhi0EokvLA_SCLPXSAwF7nMRxb1XVAlIlDrTnyLEnravEXmyn1T4LL4uXXVAF4mR55vu_sTWEHHP2gTMuP35jjEnO64bXjEEtmxdkxctRQdvCS7Latqtt_4C8SemhXDvO1GtyAA2IGkCsyI-be6Q4jmiye0SPKdEw0gkX4zzS4Om8JDMhXceQ0XmaNj7fY3LpfYG0p0OwGzrrEtPeltLdrryrGBMxuyIpwTBZjHSNYT3hGdVFlDLOOjtDIz46fPolmDHrSns9bcqII_Jq1FPCt_vzkNxeXd5cfK6uv376cnF-XZmWsVzxDgBkY4FLbAAUMyCk1bWGRo0KukYwbDm0gwCjDLddB2NtC4xMsaEGcUhOd97yye8LptzPLhmcJu0xLKnnUkrVtbJjBT35C30ISyzvLVRbS66EYKpQfEeZGFKKOPbr6GYdNz1n_XZz_T-bK5l3e_MyzGj_JH6vqgBiL9XzEJ29w2ez_6v9CRsIop4</recordid><startdate>20150114</startdate><enddate>20150114</enddate><creator>Xu, Zhe-rong</creator><creator>Tan, Zhong-ju</creator><creator>Zhang, Qin</creator><creator>Gui, Qi-feng</creator><creator>Yang, Yun-mei</creator><general>Cambridge University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7T5</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20150114</creationdate><title>The effectiveness of leucine on muscle protein synthesis, lean body mass and leg lean mass accretion in older people: a systematic review and meta-analysis</title><author>Xu, Zhe-rong ; Tan, Zhong-ju ; Zhang, Qin ; Gui, Qi-feng ; Yang, Yun-mei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c600t-1822275d217e52290c237da4a259f928530e6126b32c9c1d882f4d17ee090b423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Accretion</topic><topic>Aged</topic><topic>Amino acids</topic><topic>Body Composition</topic><topic>Body mass</topic><topic>Body Mass Index</topic><topic>Databases, Factual</topic><topic>Dietary Supplements</topic><topic>Humans</topic><topic>Leg - anatomy & histology</topic><topic>Leucine - administration & dosage</topic><topic>Muscle Proteins - biosynthesis</topic><topic>Muscle Proteins - drug effects</topic><topic>Muscle, Skeletal - drug effects</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Muscular system</topic><topic>Older people</topic><topic>Protein synthesis</topic><topic>Proteins</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Systematic review</topic><topic>Systematic Review with Meta-Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Zhe-rong</creatorcontrib><creatorcontrib>Tan, Zhong-ju</creatorcontrib><creatorcontrib>Zhang, Qin</creatorcontrib><creatorcontrib>Gui, Qi-feng</creatorcontrib><creatorcontrib>Yang, Yun-mei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Immunology Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Zhe-rong</au><au>Tan, Zhong-ju</au><au>Zhang, Qin</au><au>Gui, Qi-feng</au><au>Yang, Yun-mei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effectiveness of leucine on muscle protein synthesis, lean body mass and leg lean mass accretion in older people: a systematic review and meta-analysis</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>2015-01-14</date><risdate>2015</risdate><volume>113</volume><issue>1</issue><spage>25</spage><epage>34</epage><pages>25-34</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><abstract>In the present study, we performed a meta-analysis to assess the ability of leucine supplementation to increase the muscle protein fraction synthetic rate and to augment lean body mass or leg lean mass in elderly patients. A literature search was conducted on Medline, Cochrane, EMBASE and Google Scholar databases up to 31 December 2013 for clinical trials that investigated the administration of leucine as a nutrient that affects muscle protein metabolism and muscle mass in elderly subjects. The included studies were randomised controlled trials. The primary outcome for the meta-analysis was the protein fractional synthetic rate. Secondary outcomes included lean body mass and leg lean mass. A total of nine studies were included in the meta-analysis. The results showed that the muscle protein fractional synthetic rate after intervention significantly increased in the leucine group compared with the control group (pooled standardised difference in mean changes 1·08, 95 % CI 0·50, 1·67; P< 0·001). No difference was found between the groups in relation to lean body mass (pooled standardised difference in mean changes 0·18, 95 % CI − 0·18, 0·54; P= 0·318) or leg lean mass (pooled standardised difference in mean changes 0·006, 95 % CI − 0·32, 0·44; P= 0·756). These findings suggest that leucine supplementation is useful to address the age-related decline in muscle mass in elderly individuals, as it increases the muscle protein fractional synthetic rate.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>25234223</pmid><doi>10.1017/S0007114514002475</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of nutrition, 2015-01, Vol.113 (1), p.25-34 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry; Cambridge University Press Journals Complete |
| subjects | Accretion Aged Amino acids Body Composition Body mass Body Mass Index Databases, Factual Dietary Supplements Humans Leg - anatomy & histology Leucine - administration & dosage Muscle Proteins - biosynthesis Muscle Proteins - drug effects Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Muscular system Older people Protein synthesis Proteins Randomized Controlled Trials as Topic Systematic review Systematic Review with Meta-Analysis |
| title | The effectiveness of leucine on muscle protein synthesis, lean body mass and leg lean mass accretion in older people: a systematic review and meta-analysis |
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