Small Molecule T315 Promotes Casitas B-Lineage Lymphoma-Dependent Degradation of Epidermal Growth Factor Receptor via Y1045 Autophosphorylation

Despite the fact that tyrosine kinase inhibitors (TKIs) have been found effective in treating patients harboring activating mutations of epidermal growth factor receptor (EGFR), an acquired secondary mutation, T790M, which lowers the affinity to TKIs, can lead to EGFR TKI resistance after this stand...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2016-04, Vol.193 (7), p.753-766
Hauptverfasser:	Huang, Kuo-Yen, Kao, Shih-Han, Wang, Wen-Lung, Chen, Chi-Yuan, Hsiao, Tzu-Hung, Salunke, Santosh B, Chen, Jeremy J W, Su, Kang-Yi, Yang, Shuenn-Chen, Hong, Tse-Ming, Chen, Ching-Shih, Yang, Pan-Chyr
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - drug effects Adaptor Proteins, Signal Transducing - genetics Adenocarcinoma - drug therapy Adenocarcinoma - genetics Adenocarcinoma of Lung Afatinib Animals Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Blotting, Western Cell Proliferation - drug effects Drug Combinations Drug Resistance, Neoplasm - drug effects Enzyme Assays ErbB Receptors - antagonists & inhibitors ErbB Receptors - drug effects ErbB Receptors - genetics Humans Lung Neoplasms - drug therapy Lung Neoplasms - genetics Mass Spectrometry Mice Mutation - genetics Protein Kinase Inhibitors - adverse effects Protein Kinase Inhibitors - therapeutic use Proto-Oncogene Proteins c-cbl - drug effects Proto-Oncogene Proteins c-cbl - genetics Quinazolines - adverse effects Quinazolines - therapeutic use Real-Time Polymerase Chain Reaction Tumor Cells, Cultured Xenograft Model Antitumor Assays
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