Lymph node trafficking of regulatory T cells is prerequisite for immune suppression

Abrogation of Treg‐mediated immunosuppression by blockage of Treg LN trafficking suggests a hierarchy of the anatomic sites for immune regulation in Treg‐based cell therapy. Regulatory T cells have a crucial role in health and disease because of their immune regulation function. However, the anatomi...

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Veröffentlicht in:	Journal of leukocyte biology 2016-04, Vol.99 (4), p.561-568
Hauptverfasser:	Huang, Miao‐Tzu, Lin, Been‐Ren, Liu, Wei‐Liang, Lu, Chun‐Wei, Chiang, Bor‐Luen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals Antibodies, Neutralizing - pharmacology CCR7 Cell Movement - drug effects Cell Movement - immunology footpad inflammation immune regulation Immune Tolerance Inflammation L-Selectin - immunology leukocyte trafficking Lymph Nodes - immunology Lymph Nodes - pathology Mice Mice, Inbred BALB C Mice, Transgenic Receptors, CCR7 - antagonists & inhibitors Receptors, CCR7 - immunology T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - pathology
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