Suppression of activation of muscle sympathetic nerve during non-noxious local cooling after the end of local cooling in normal adults
Purpose While non-noxious local cooling is widely used in physical medicine, its effect on muscle sympathetic nerve activity (MSNA) and cardiovascular regulation are not clear. The purpose of the present study was to assess the responses of MSNA, blood pressure (BP), heart rate (HR) and local blood...
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| Veröffentlicht in: | European journal of applied physiology 2016-04, Vol.116 (4), p.851-858 |
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| container_title | European journal of applied physiology |
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| creator | Ishida, Kazuya Nakamura, Takeshi Kimura, Kenichi Kanno, Nami Takahashi, Noriyo Kamijo, Yoshi-ichiro Tajima, Fumihiro |
| description | Purpose
While non-noxious local cooling is widely used in physical medicine, its effect on muscle sympathetic nerve activity (MSNA) and cardiovascular regulation are not clear. The purpose of the present study was to assess the responses of MSNA, blood pressure (BP), heart rate (HR) and local blood flow during non-noxious local cooling.
Methods
The study included two protocols. Both protocols consisted of 10-min rest in supine position, followed by 15-min local cooling (15 °C) of the shin and anterior foot, and 20-min recovery. MSNA of the right common peroneal nerve, BP, HR, and shin skin temperature (TSK) were recorded in eight men in the first protocol, while leg blood flow (LBF) was measured in the same subjects by strain-gauge plethysmography in the second protocol.
Results
TSK gradually decreased from 31.5 ± 0.02 to 16.0 ± 1.01 °C (mean ± SEM) during local cooling, and gradually increased after the end of local cooling. No subject complained of pain, and BP and HR remained constant. The MSNA burst rate increased significantly (
p
|
| doi_str_mv | 10.1007/s00421-016-3343-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1777982286</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4004263171</sourcerecordid><originalsourceid>FETCH-LOGICAL-c481t-63b0d11b3bbad4f27a4cc472ecf9eac71fc72ca9ba0cc93d02535c93360dc54d3</originalsourceid><addsrcrecordid>eNp1kc1u3SAQhVHUKjd_D9BNhdRNNm75u8Yso6hNIkXKou0a4QGnvrLBARMlL5DnLpZvorZSVwzMdw4MB6EPlHymhMgviRDBaEVoXXEueKUO0BEVXFU1Z_LdW03VBh2ntCOENIw2h2jD6kZtmaiP0Mv3PE3RpdQHj0OHDcz9o5n3uzEnGBxOz-Nk5l9u7gF7Fx8dtjn2_h774CsfnvqQEx4CmAFDCMPSMd3sIi4a7LxdrP5u975o41hOjM3DnE7R-84MyZ3t1xP089vXH5fX1e3d1c3lxW0FoqFzmaUlltKWt62xomPSCAAhmYNOOQOSdiAZGNUaAqC4JWzLt6XgNbGwFZafoPPVd4rhIbs067FP4IbBeFeG0FRKqRrGmrqgn_5BdyFHX163ULVsaEN5oehKQQwpRdfpKfajic-aEr2EpNeQdAlJLyFpVTQf9865HZ19U7ymUgC2AmlavtnFP67-r-tvrt-fbw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1776781813</pqid></control><display><type>article</type><title>Suppression of activation of muscle sympathetic nerve during non-noxious local cooling after the end of local cooling in normal adults</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Ishida, Kazuya ; Nakamura, Takeshi ; Kimura, Kenichi ; Kanno, Nami ; Takahashi, Noriyo ; Kamijo, Yoshi-ichiro ; Tajima, Fumihiro</creator><creatorcontrib>Ishida, Kazuya ; Nakamura, Takeshi ; Kimura, Kenichi ; Kanno, Nami ; Takahashi, Noriyo ; Kamijo, Yoshi-ichiro ; Tajima, Fumihiro</creatorcontrib><description>Purpose
While non-noxious local cooling is widely used in physical medicine, its effect on muscle sympathetic nerve activity (MSNA) and cardiovascular regulation are not clear. The purpose of the present study was to assess the responses of MSNA, blood pressure (BP), heart rate (HR) and local blood flow during non-noxious local cooling.
Methods
The study included two protocols. Both protocols consisted of 10-min rest in supine position, followed by 15-min local cooling (15 °C) of the shin and anterior foot, and 20-min recovery. MSNA of the right common peroneal nerve, BP, HR, and shin skin temperature (TSK) were recorded in eight men in the first protocol, while leg blood flow (LBF) was measured in the same subjects by strain-gauge plethysmography in the second protocol.
Results
TSK gradually decreased from 31.5 ± 0.02 to 16.0 ± 1.01 °C (mean ± SEM) during local cooling, and gradually increased after the end of local cooling. No subject complained of pain, and BP and HR remained constant. The MSNA burst rate increased significantly (
p
< 0.05) to 141.1 ± 12.5 % during local cooling, but decreased significantly (
p
< 0.05) to 73.6 ± 5.9 % during the recovery period. Total MSNA also increased to 148.0 ± 14.2 % (
p
< 0.05) during local cooling, and decreased to 74.0 ± 13.9 % (
p
< 0.05) at recovery. LBF remained constant through the experiment.
Conclusions
The results suggest that MSNA is activated by non-noxious local cooling, and attenuated after the end of local cooling without any changes in HR and BP.</description><identifier>ISSN: 1439-6319</identifier><identifier>EISSN: 1439-6327</identifier><identifier>DOI: 10.1007/s00421-016-3343-9</identifier><identifier>PMID: 26895246</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Biomedical and Life Sciences ; Biomedicine ; Blood Pressure ; Cooling ; Cryotherapy ; Health sciences ; Heart Rate ; Human Physiology ; Humans ; Hypothermia, Induced ; Male ; Muscle, Skeletal - innervation ; Muscle, Skeletal - physiology ; Neuromuscular diseases ; Occupational Medicine/Industrial Medicine ; Original Article ; Regional Blood Flow ; Skin ; Skin Temperature ; Sports Medicine ; Sympathetic Nervous System - physiology</subject><ispartof>European journal of applied physiology, 2016-04, Vol.116 (4), p.851-858</ispartof><rights>Springer-Verlag Berlin Heidelberg 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-63b0d11b3bbad4f27a4cc472ecf9eac71fc72ca9ba0cc93d02535c93360dc54d3</citedby><cites>FETCH-LOGICAL-c481t-63b0d11b3bbad4f27a4cc472ecf9eac71fc72ca9ba0cc93d02535c93360dc54d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00421-016-3343-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00421-016-3343-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26895246$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ishida, Kazuya</creatorcontrib><creatorcontrib>Nakamura, Takeshi</creatorcontrib><creatorcontrib>Kimura, Kenichi</creatorcontrib><creatorcontrib>Kanno, Nami</creatorcontrib><creatorcontrib>Takahashi, Noriyo</creatorcontrib><creatorcontrib>Kamijo, Yoshi-ichiro</creatorcontrib><creatorcontrib>Tajima, Fumihiro</creatorcontrib><title>Suppression of activation of muscle sympathetic nerve during non-noxious local cooling after the end of local cooling in normal adults</title><title>European journal of applied physiology</title><addtitle>Eur J Appl Physiol</addtitle><addtitle>Eur J Appl Physiol</addtitle><description>Purpose
While non-noxious local cooling is widely used in physical medicine, its effect on muscle sympathetic nerve activity (MSNA) and cardiovascular regulation are not clear. The purpose of the present study was to assess the responses of MSNA, blood pressure (BP), heart rate (HR) and local blood flow during non-noxious local cooling.
Methods
The study included two protocols. Both protocols consisted of 10-min rest in supine position, followed by 15-min local cooling (15 °C) of the shin and anterior foot, and 20-min recovery. MSNA of the right common peroneal nerve, BP, HR, and shin skin temperature (TSK) were recorded in eight men in the first protocol, while leg blood flow (LBF) was measured in the same subjects by strain-gauge plethysmography in the second protocol.
Results
TSK gradually decreased from 31.5 ± 0.02 to 16.0 ± 1.01 °C (mean ± SEM) during local cooling, and gradually increased after the end of local cooling. No subject complained of pain, and BP and HR remained constant. The MSNA burst rate increased significantly (
p
< 0.05) to 141.1 ± 12.5 % during local cooling, but decreased significantly (
p
< 0.05) to 73.6 ± 5.9 % during the recovery period. Total MSNA also increased to 148.0 ± 14.2 % (
p
< 0.05) during local cooling, and decreased to 74.0 ± 13.9 % (
p
< 0.05) at recovery. LBF remained constant through the experiment.
Conclusions
The results suggest that MSNA is activated by non-noxious local cooling, and attenuated after the end of local cooling without any changes in HR and BP.</description><subject>Adult</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood Pressure</subject><subject>Cooling</subject><subject>Cryotherapy</subject><subject>Health sciences</subject><subject>Heart Rate</subject><subject>Human Physiology</subject><subject>Humans</subject><subject>Hypothermia, Induced</subject><subject>Male</subject><subject>Muscle, Skeletal - innervation</subject><subject>Muscle, Skeletal - physiology</subject><subject>Neuromuscular diseases</subject><subject>Occupational Medicine/Industrial Medicine</subject><subject>Original Article</subject><subject>Regional Blood Flow</subject><subject>Skin</subject><subject>Skin Temperature</subject><subject>Sports Medicine</subject><subject>Sympathetic Nervous System - physiology</subject><issn>1439-6319</issn><issn>1439-6327</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kc1u3SAQhVHUKjd_D9BNhdRNNm75u8Yso6hNIkXKou0a4QGnvrLBARMlL5DnLpZvorZSVwzMdw4MB6EPlHymhMgviRDBaEVoXXEueKUO0BEVXFU1Z_LdW03VBh2ntCOENIw2h2jD6kZtmaiP0Mv3PE3RpdQHj0OHDcz9o5n3uzEnGBxOz-Nk5l9u7gF7Fx8dtjn2_h774CsfnvqQEx4CmAFDCMPSMd3sIi4a7LxdrP5u975o41hOjM3DnE7R-84MyZ3t1xP089vXH5fX1e3d1c3lxW0FoqFzmaUlltKWt62xomPSCAAhmYNOOQOSdiAZGNUaAqC4JWzLt6XgNbGwFZafoPPVd4rhIbs067FP4IbBeFeG0FRKqRrGmrqgn_5BdyFHX163ULVsaEN5oehKQQwpRdfpKfajic-aEr2EpNeQdAlJLyFpVTQf9865HZ19U7ymUgC2AmlavtnFP67-r-tvrt-fbw</recordid><startdate>20160401</startdate><enddate>20160401</enddate><creator>Ishida, Kazuya</creator><creator>Nakamura, Takeshi</creator><creator>Kimura, Kenichi</creator><creator>Kanno, Nami</creator><creator>Takahashi, Noriyo</creator><creator>Kamijo, Yoshi-ichiro</creator><creator>Tajima, Fumihiro</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20160401</creationdate><title>Suppression of activation of muscle sympathetic nerve during non-noxious local cooling after the end of local cooling in normal adults</title><author>Ishida, Kazuya ; Nakamura, Takeshi ; Kimura, Kenichi ; Kanno, Nami ; Takahashi, Noriyo ; Kamijo, Yoshi-ichiro ; Tajima, Fumihiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-63b0d11b3bbad4f27a4cc472ecf9eac71fc72ca9ba0cc93d02535c93360dc54d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blood Pressure</topic><topic>Cooling</topic><topic>Cryotherapy</topic><topic>Health sciences</topic><topic>Heart Rate</topic><topic>Human Physiology</topic><topic>Humans</topic><topic>Hypothermia, Induced</topic><topic>Male</topic><topic>Muscle, Skeletal - innervation</topic><topic>Muscle, Skeletal - physiology</topic><topic>Neuromuscular diseases</topic><topic>Occupational Medicine/Industrial Medicine</topic><topic>Original Article</topic><topic>Regional Blood Flow</topic><topic>Skin</topic><topic>Skin Temperature</topic><topic>Sports Medicine</topic><topic>Sympathetic Nervous System - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ishida, Kazuya</creatorcontrib><creatorcontrib>Nakamura, Takeshi</creatorcontrib><creatorcontrib>Kimura, Kenichi</creatorcontrib><creatorcontrib>Kanno, Nami</creatorcontrib><creatorcontrib>Takahashi, Noriyo</creatorcontrib><creatorcontrib>Kamijo, Yoshi-ichiro</creatorcontrib><creatorcontrib>Tajima, Fumihiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of applied physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ishida, Kazuya</au><au>Nakamura, Takeshi</au><au>Kimura, Kenichi</au><au>Kanno, Nami</au><au>Takahashi, Noriyo</au><au>Kamijo, Yoshi-ichiro</au><au>Tajima, Fumihiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Suppression of activation of muscle sympathetic nerve during non-noxious local cooling after the end of local cooling in normal adults</atitle><jtitle>European journal of applied physiology</jtitle><stitle>Eur J Appl Physiol</stitle><addtitle>Eur J Appl Physiol</addtitle><date>2016-04-01</date><risdate>2016</risdate><volume>116</volume><issue>4</issue><spage>851</spage><epage>858</epage><pages>851-858</pages><issn>1439-6319</issn><eissn>1439-6327</eissn><abstract>Purpose
While non-noxious local cooling is widely used in physical medicine, its effect on muscle sympathetic nerve activity (MSNA) and cardiovascular regulation are not clear. The purpose of the present study was to assess the responses of MSNA, blood pressure (BP), heart rate (HR) and local blood flow during non-noxious local cooling.
Methods
The study included two protocols. Both protocols consisted of 10-min rest in supine position, followed by 15-min local cooling (15 °C) of the shin and anterior foot, and 20-min recovery. MSNA of the right common peroneal nerve, BP, HR, and shin skin temperature (TSK) were recorded in eight men in the first protocol, while leg blood flow (LBF) was measured in the same subjects by strain-gauge plethysmography in the second protocol.
Results
TSK gradually decreased from 31.5 ± 0.02 to 16.0 ± 1.01 °C (mean ± SEM) during local cooling, and gradually increased after the end of local cooling. No subject complained of pain, and BP and HR remained constant. The MSNA burst rate increased significantly (
p
< 0.05) to 141.1 ± 12.5 % during local cooling, but decreased significantly (
p
< 0.05) to 73.6 ± 5.9 % during the recovery period. Total MSNA also increased to 148.0 ± 14.2 % (
p
< 0.05) during local cooling, and decreased to 74.0 ± 13.9 % (
p
< 0.05) at recovery. LBF remained constant through the experiment.
Conclusions
The results suggest that MSNA is activated by non-noxious local cooling, and attenuated after the end of local cooling without any changes in HR and BP.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>26895246</pmid><doi>10.1007/s00421-016-3343-9</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1439-6319 |
| ispartof | European journal of applied physiology, 2016-04, Vol.116 (4), p.851-858 |
| issn | 1439-6319 1439-6327 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Adult Biomedical and Life Sciences Biomedicine Blood Pressure Cooling Cryotherapy Health sciences Heart Rate Human Physiology Humans Hypothermia, Induced Male Muscle, Skeletal - innervation Muscle, Skeletal - physiology Neuromuscular diseases Occupational Medicine/Industrial Medicine Original Article Regional Blood Flow Skin Skin Temperature Sports Medicine Sympathetic Nervous System - physiology |
| title | Suppression of activation of muscle sympathetic nerve during non-noxious local cooling after the end of local cooling in normal adults |
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