The influence of n-3 fatty acids on maternal behavior and brain monoamines in the perinatal period
Abstract The aim of this study was to use n-3 fatty acid-deficient pregnant mice to assess maternal behavior in the perinatal period. Female mice were fed either an n-3 fatty acid-deficient (n-3 Def) or -adequate (n-3 Adq) diet for two generations. The nest score and volume of the n-3 Def dams were...
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| Veröffentlicht in: | Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 2016-04, Vol.107, p.1-7 |
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| container_title | Prostaglandins, leukotrienes and essential fatty acids |
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| creator | Harauma, Akiko Sagisaka, Takayuki Horii, Taku Watanabe, Yoshitake Moriguchi, Toru |
| description | Abstract The aim of this study was to use n-3 fatty acid-deficient pregnant mice to assess maternal behavior in the perinatal period. Female mice were fed either an n-3 fatty acid-deficient (n-3 Def) or -adequate (n-3 Adq) diet for two generations. The nest score and volume of the n-3 Def dams were lower than those of the n-3 Adq dams. In the observation of the post-delivery conditions, 40% of the n-3 Def dams attacked their newborns or did not nurse them. The brain docosahexaenoic acid (DHA) levels of the n-3 Def dams were lower than those of the n-3 Adq dams. In the hippocampus, moreover, positive correlations were observed between the DHA and the 5-HT or 5-HIAA, and a negative correlation was observed between the DHA and the DA. These results suggest that dietary n-3 fatty acids may normalize the development of maternal behavior and prevent postpartum depression. |
| doi_str_mv | 10.1016/j.plefa.2016.02.004 |
| format | Article |
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Female mice were fed either an n-3 fatty acid-deficient (n-3 Def) or -adequate (n-3 Adq) diet for two generations. The nest score and volume of the n-3 Def dams were lower than those of the n-3 Adq dams. In the observation of the post-delivery conditions, 40% of the n-3 Def dams attacked their newborns or did not nurse them. The brain docosahexaenoic acid (DHA) levels of the n-3 Def dams were lower than those of the n-3 Adq dams. In the hippocampus, moreover, positive correlations were observed between the DHA and the 5-HT or 5-HIAA, and a negative correlation was observed between the DHA and the DA. 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Female mice were fed either an n-3 fatty acid-deficient (n-3 Def) or -adequate (n-3 Adq) diet for two generations. The nest score and volume of the n-3 Def dams were lower than those of the n-3 Adq dams. In the observation of the post-delivery conditions, 40% of the n-3 Def dams attacked their newborns or did not nurse them. The brain docosahexaenoic acid (DHA) levels of the n-3 Def dams were lower than those of the n-3 Adq dams. In the hippocampus, moreover, positive correlations were observed between the DHA and the 5-HT or 5-HIAA, and a negative correlation was observed between the DHA and the DA. These results suggest that dietary n-3 fatty acids may normalize the development of maternal behavior and prevent postpartum depression.</description><subject>Advanced Basic Science</subject><subject>Animals</subject><subject>Biogenic Monoamines - metabolism</subject><subject>Brain - metabolism</subject><subject>Diet</subject><subject>Docosahexaenoic Acids - pharmacology</subject><subject>Endocrinology & Metabolism</subject><subject>Feeding Behavior</subject><subject>Female</subject><subject>Maternal behavior</subject><subject>Maternal Behavior - drug effects</subject><subject>Mice, Inbred C57BL</subject><subject>Monoamine</subject><subject>n-3 fatty acid</subject><subject>Nest building</subject><subject>Nesting Behavior</subject><subject>Nursing</subject><subject>Perinatal period</subject><subject>Pregnancy</subject><issn>0952-3278</issn><issn>1532-2823</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1DAUhS0EotPCL0BCXrJJ6ldiZwESqoBWqsSi7dq6cW5UD4k92Eml-fc4TGHBhpVt-Zz7-A4h7zirOePt5b4-TDhCLcqjZqJmTL0gO95IUQkj5EuyY10jKim0OSPnOe8ZY4Jz9ZqcCc2kVLzbkf7-EakP47RicEjjSEMl6QjLcqTg_JBpDHSGBVOAifb4CE8-JgphoH0CX_5iiDD7gLmUoUupdsDkAyxFvt3i8Ia8GmHK-Pb5vCAPX7_cX11Xt9-_3Vx9vq2cMmypBtVr7IUc27bvDDjRmW1-Lls2aNGW2UEWoWA9B6V000gziIY1GrAzBpS8IB9OdQ8p_lwxL3b22eE0QcC4Zsu11p3ujBJFKk9Sl2LOCUd7SH6GdLSc2Q2u3dvfcO0G1zJhC9ziev_cYO1nHP56_tAsgo8nAZY1nzwmm53fuA4-oVvsEP1_Gnz6x-8mH7yD6QceMe_juqVQNrG5GOzdxmeLt2TOWNN28hfXHJ7Z</recordid><startdate>20160401</startdate><enddate>20160401</enddate><creator>Harauma, Akiko</creator><creator>Sagisaka, Takayuki</creator><creator>Horii, Taku</creator><creator>Watanabe, Yoshitake</creator><creator>Moriguchi, Toru</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160401</creationdate><title>The influence of n-3 fatty acids on maternal behavior and brain monoamines in the perinatal period</title><author>Harauma, Akiko ; Sagisaka, Takayuki ; Horii, Taku ; Watanabe, Yoshitake ; Moriguchi, Toru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c480t-d4b7eb23f66b98ac29809521360d726002a348020b1a4475538d25057ae988a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Advanced Basic Science</topic><topic>Animals</topic><topic>Biogenic Monoamines - metabolism</topic><topic>Brain - metabolism</topic><topic>Diet</topic><topic>Docosahexaenoic Acids - pharmacology</topic><topic>Endocrinology & Metabolism</topic><topic>Feeding Behavior</topic><topic>Female</topic><topic>Maternal behavior</topic><topic>Maternal Behavior - drug effects</topic><topic>Mice, Inbred C57BL</topic><topic>Monoamine</topic><topic>n-3 fatty acid</topic><topic>Nest building</topic><topic>Nesting Behavior</topic><topic>Nursing</topic><topic>Perinatal period</topic><topic>Pregnancy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harauma, Akiko</creatorcontrib><creatorcontrib>Sagisaka, Takayuki</creatorcontrib><creatorcontrib>Horii, Taku</creatorcontrib><creatorcontrib>Watanabe, Yoshitake</creatorcontrib><creatorcontrib>Moriguchi, Toru</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Prostaglandins, leukotrienes and essential fatty acids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harauma, Akiko</au><au>Sagisaka, Takayuki</au><au>Horii, Taku</au><au>Watanabe, Yoshitake</au><au>Moriguchi, Toru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The influence of n-3 fatty acids on maternal behavior and brain monoamines in the perinatal period</atitle><jtitle>Prostaglandins, leukotrienes and essential fatty acids</jtitle><addtitle>Prostaglandins Leukot Essent Fatty Acids</addtitle><date>2016-04-01</date><risdate>2016</risdate><volume>107</volume><spage>1</spage><epage>7</epage><pages>1-7</pages><issn>0952-3278</issn><eissn>1532-2823</eissn><abstract>Abstract The aim of this study was to use n-3 fatty acid-deficient pregnant mice to assess maternal behavior in the perinatal period. 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| identifier | ISSN: 0952-3278 |
| ispartof | Prostaglandins, leukotrienes and essential fatty acids, 2016-04, Vol.107, p.1-7 |
| issn | 0952-3278 1532-2823 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Advanced Basic Science Animals Biogenic Monoamines - metabolism Brain - metabolism Diet Docosahexaenoic Acids - pharmacology Endocrinology & Metabolism Feeding Behavior Female Maternal behavior Maternal Behavior - drug effects Mice, Inbred C57BL Monoamine n-3 fatty acid Nest building Nesting Behavior Nursing Perinatal period Pregnancy |
| title | The influence of n-3 fatty acids on maternal behavior and brain monoamines in the perinatal period |
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