XP-A cells complemented with Arg228Gln and Val234Leu polymorphic XPA alleles repair BPDE-induced DNA damage better than cells complemented with the wild type allele

Functional effects of Arg228Gln and Val2343Leu XPA polymorphisms on benzo[ a]pyrene-r-7,t-8-dihydrodiol-t-9,10-epoxide-(±)- anti (BPDE) survival and repair were investigated in SV40 immortalized XP12RO cells complemented with wild type and polymorphic XPA cDNAs in an inducible cDNA expression system...

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Veröffentlicht in:	DNA repair 2005-03, Vol.4 (3), p.341-349
Hauptverfasser:	Porter, Paul C., Mellon, Isabel, States, J. Christopher
Format:	Artikel
Sprache:	eng
Schlagworte:	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide - toxicity Alleles Arginine - genetics Bacteriology Benzo[ a]pyrene-diol-epoxide Biological and medical sciences DNA Damage DNA Repair DNA-Binding Proteins - genetics Fundamental and applied biological sciences. Psychology Genes, Reporter Genetic Complementation Test Glycine - genetics Growth, nutrition, cell differenciation Leucine - genetics Microbiology Molecular and cellular biology Molecular genetics Mutagenesis. Repair Poly(ADP-ribose) Polymorphism Polymorphism, Genetic Simian virus 40 Valine - genetics Xeroderma Pigmentosum Group A Protein XPA
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